Results 61 to 70 of about 13,609,830 (345)
A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes. [PDF]
The EMBO Journal, 1993 Both cyclins A and B associate with and thereby activate cyclin-dependent protein kinases (cdks). We have investigated which component in the cyclin-cdk complex determines its substrate specificity. The A- and B-type cyclin-cdk complexes phosphorylated histone H1 and their cyclin subunits in an indistinguishable manner, irrespective of the catalytic ...
H. Piwnica-Worms +8 more
openaire +3 more sources
Biomarker Research, 2019 Background A subset of diffuse large B-cell lymphoma may show aberrant cyclin D1 expression, which may be confused with blastoid mantle cell lymphoma. These cases usually lack of CCND1 gene rearrangement.
Da Gao, Zach Liu
doaj +1 more source
Genomic landscape of salivary gland tumors. [PDF]
, 2015 Effective treatment options for advanced salivary gland tumors are lacking. To better understand these tumors, we report their genomic landscape. We studied the molecular aberrations in 117 patients with salivary gland tumors that were, on physician ...
Carter, Jennifer L +6 more
core +2 more sources
Journal of Biological Chemistry, 2012 Background: Pah1p, a phosphatidate phosphatase in yeast, produces diacylglycerol for lipid synthesis. Results: Phosphorylation of Pah1p by protein kinase A inhibited membrane association, phosphatidate phosphatase activity, and triacylglycerol synthesis.
Wen‐Min Su +3 more
semanticscholar +1 more source
Exploring cell cycle-mediated regulations of glycolysis in budding yeast
Frontiers in Microbiology, 2023 Coordination of cell cycle with metabolism exists in all cell types that grow by division. It serves to build a new cell, (i) fueling building blocks for the synthesis of proteins, nucleic acids, and membranes, and (ii) producing energy through ...
Yanfei Zhang +4 more
doaj +1 more source
PLoS ONE, 2014 During embryonic development of Artemia sinica, environmental stresses induce the embryo diapause phenomenon, required to resist apoptosis and regulate cell cycle activity.
Bing Chu +9 more
doaj +1 more source
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation [PDF]
, 1993 In normal human diploid fibroblasts, cyclins of the A, B, and D classes each associate with cyclin-dependent kinases (CDKs), proliferating cell nuclear antigen (PCNA), and p21, thereby forming multiple independent quaternary complexes.
Beach, D., Xiong, Y., Zhang, H.
core +1 more source
Phosphorylation of AIB1 at Mitosis Is Regulated by CDK1/CYCLIN B
PLoS ONE, 2011 Although the AIB1 oncogene has an important role during the early phase of the cell cycle as a coactivator of E2F1, little is known about its function during mitosis.Mitotic cells isolated by nocodazole treatment as well as by shake-off revealed a post-translational modification occurring in AIB1 specifically during mitosis.
Ferrero, Macarena +6 more
openaire +9 more sources
Haematologica, 2009 In a subset of B-cell malignancies, the genes encoding members of the cyclin D familiy are juxtaposed to immunoglobulin loci through recurrent chromosomal translocations.
Inga Nagel +9 more
doaj +1 more source
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation [PDF]
, 2018 p27$^{Kip1}$ (p27) is an intrinsically disordered protein (IDP) that folds upon binding to cyclin-dependent kinase (Cdk)$/$cyclin complexes (e.g., Cdk2$/$cyclin A), inhibiting their catalytic activity and causing cell cycle arrest. However, cell division progresses when stably Cdk2$/$cyclin A-bound p27 is phosphorylated on one or two structurally ...
arxiv +1 more source