Results 41 to 50 of about 222,589 (257)
Distinct and Overlapping Requirements for Cyclins A, B, and B3 in Drosophila Female Meiosis
G3: Genes, Genomes, Genetics, 2016 Meiosis, like mitosis, depends on the activity of the cyclin dependent kinase Cdk1 and its cyclin partners. Here, we examine the specific requirements for the three mitotic cyclins, A, B, and B3 in meiosis of Drosophila melanogaster.
Mohammed Bourouh +5 more
doaj +1 more source
Exploring cell cycle-mediated regulations of glycolysis in budding yeast
Frontiers in Microbiology, 2023 Coordination of cell cycle with metabolism exists in all cell types that grow by division. It serves to build a new cell, (i) fueling building blocks for the synthesis of proteins, nucleic acids, and membranes, and (ii) producing energy through ...
Yanfei Zhang +4 more
doaj +1 more source
A model for regulation of the cell cycle incorporating cyclin A, cyclin B and their complexes
Cell Proliferation, 1994 Abstract. t. A mathematical model for the cell cycle is proposed that incorporates the known biochemical reactions involving both cyclin A and cyclin B, the interactions of these cyclins with cdc2 and cdk2, and the controlling effects of cdc25 and weel.
M N, Obeyesekere +2 more
openaire +2 more sources
The EMBO Journal, 1994 Cyclins play a key role in controlling progression through the cell cycle. They act as regulatory subunits of p34cdc2/CDC28 and related cyclin-dependent protein kinases (cdks). In vertebrates, cyclins B1 and B2 function during M phase, whereas cyclin A is required for S phase as well as the G2 to M phase transition. Here, we describe the identification
Gallant, P., Nigg, E. A.
openaire +2 more sources
Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.
PLoS ONE, 2012 Disruption of early mitotic inhibitor 1 (Emi1) interferes with normal cell cycle progression and results in early embryonic lethality in vertebrates. During S and G2 phases the ubiquitin ligase complex APC/C is inhibited by Emi1 protein, thereby enabling
Mara E Robu, Yong Zhang, Jennifer Rhodes
doaj +1 more source
p53 Dimers associate with a head-to-tail response element to repress cyclin B transcription. [PDF]
PLoS ONE, 2012 DNA damage induced by the topoisomerase I inhibitor SN38 activates cell cycle checkpoints which promote cell cycle arrest. This arrest can be abrogated in p53-defective cells by the Chk1 inhibitor 7-hydroxystaurosporine (UCN-01).
Robert Lipski +6 more
doaj +1 more source
Biomarker Research, 2019 Background A subset of diffuse large B-cell lymphoma may show aberrant cyclin D1 expression, which may be confused with blastoid mantle cell lymphoma. These cases usually lack of CCND1 gene rearrangement.
Da Gao, Zach Liu
doaj +1 more source
The role of cyclin B in meiosis I. [PDF]
The Journal of cell biology, 1989 In clams, fertilization is followed by the prominent synthesis of two cyclins, A and B. During the mitotic cell cycles, the two cyclins are accumulated and then destroyed near the end of each metaphase. Newly synthesized cyclin B is complexed with a small set of other proteins, including a kinase that phosphorylates cyclin B in vitro.
J M, Westendorf +2 more
openaire +2 more sources
PLoS ONE, 2014 During embryonic development of Artemia sinica, environmental stresses induce the embryo diapause phenomenon, required to resist apoptosis and regulate cell cycle activity.
Bing Chu +9 more
doaj +1 more source
PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas
Frontiers in Oncology, 2022 PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, PKM2 knock-down resulted in an
Shigeo Ohba +6 more
doaj +1 more source