Results 31 to 40 of about 222,589 (257)
BMC Complementary and Alternative Medicine, 2018 Background Although the inhibitory effect of mistletoe on cancer cell growth has been reported, the underlying mechanisms to explain its anti-proliferative activity are not fully studied.
Su Bin Park +7 more
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The ‘destruction box’ of cyclin A allows B‐type cyclins to be ubiquitinated, but not efficiently destroyed. [PDF]
The EMBO Journal, 1996 The destruction of mitotic cyclins by programmed proteolysis at the end of mitosis is an important element in cell cycle control. This proteolysis depends on a conserved motif of nine residues known as the 'destruction box', which is located 40-50 residues from the N-terminus. The sequences of the A- and B-type destruction boxes are slightly different,
A, Klotzbücher +3 more
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Inhibition of membrane fusion in vitro via cyclin B but not cyclin A.
Journal of Biological Chemistry, 1992 It is now clear that complexes of cdc2 kinase with "mitotic" cyclins regulate the transition between the G2 phase of the cell cycle and mitosis and that membrane traffic in mammalian cells is arrested during mitosis. Using a cell-free assay, we have previously reported that the fusion of early endosomes is, in fact, inhibited via the cdc2 kinase ...
Thomas, Leo +3 more
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A‐ and B‐type cyclins differentially modulate substrate specificity of cyclin‐cdk complexes. [PDF]
The EMBO Journal, 1993 Both cyclins A and B associate with and thereby activate cyclin-dependent protein kinases (cdks). We have investigated which component in the cyclin-cdk complex determines its substrate specificity. The A- and B-type cyclin-cdk complexes phosphorylated histone H1 and their cyclin subunits in an indistinguishable manner, irrespective of the catalytic ...
D S, Peeper +8 more
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The roles of Drosophila cyclins A and B in mitotic control [PDF]
Cell, 1990 We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis.
C F, Lehner, P H, O'Farrell
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Carrying-over effects of GVBD blocking on post-blocking meiotic progression of oocytes: species difference and the signaling pathway leading to MPF activation. [PDF]
PLoS ONE, 2014 Efforts to improve the quality of in vitro matured oocytes by blocking germinal vesicle breakdown (GVBD) and allowing more time for ooplasmic maturation have achieved little due to a lack of knowledge on the molecular events during GVBD blocking.
Guang-Zhong Jiao +7 more
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Characterization and localization of cyclin B3 transcript in both oocyte and spermatocyte of the rainbow trout (Oncorhynchus mykiss) [PDF]
PeerJ, 2019 B-type cyclins are regulatory subunits with distinct roles in the cell cycle. To date, at least three subtypes of B-type cyclins (B1, B2, and B3) have been identified in vertebrates. Previously, we reported the characterization and expression profiles of
Wenzhi Guan +5 more
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Regulation of B-Myb activity by cyclin D1 [PDF]
Oncogene, 2000 Evidence obtained during recent years suggests that B-Myb, a highly conserved member of the Myb transcription factor family, plays a key role in cell proliferation. We have shown previously that the activity of B-Myb is stimulated by cyclin A/Cdk2-dependent phosphorylation of the carboxyl-terminus of B-Myb.
S, Horstmann +2 more
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Biomolecules, 2021 Botryococcus braunii produce liquid hydrocarbons able to be processed into combustion engine fuels. Depending on the growing conditions, the cell doubling time can be up to 6 days or more, which is a slow growth rate in comparison with other microalgae ...
Xochitl Morales-de la Cruz +6 more
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Phosphorylation and activation of B-Myb by cyclin A–Cdk2 [PDF]
Current Biology, 1997 Cyclins and their catalytic partners, the cyclin-dependent kinases (Cdks), function as key regulators of the eukaryotic cell cycle. Specific cyclin-Cdk complexes are active at successive stages during the cell cycle and control cell-cycle progression by phosphorylating specific target proteins, most of which have not yet been identified.
Ziebold, Ulrike +4 more
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