The kinetics of G2 and M transitions regulated by B cyclins. [PDF]
PLoS ONE, 2013 B cyclins regulate G2-M transition. Because human somatic cells continue to cycle after reduction of cyclin B1 (cycB1) or cyclin B2 (cycB2) by RNA interference (RNAi), and because cycB2 knockout mice are viable, the existence of two genes should be an ...
Yehong Huang +2 more
doaj +4 more sources
Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B. [PDF]
EMBO J, 2020 Abstract Two mitotic cyclin types, cyclin A and B, exist in higher eukaryotes, but their specialised functions in mitosis are incompletely understood. Using degron tags for rapid inducible protein removal, we analyse how acute depletion of these proteins affects mitosis. Loss of cyclin A in G2‐phase prevents mitotic entry.
Hégarat N +13 more
europepmc +6 more sources
The effect of vitrification after warming on the expressions of p38, CDK1, and cyclin B in immature goat oocytes followed by in vitro maturation. [PDF]
Vet World, 2020 Background and Aim: The combination of vitrification techniques and in vitro maturation can reduce oocyte competence. Mitogen-activated protein kinase and maturation-promoting factor are significant in oocyte meiotic maturation regulation.
Kasman AAMN, Santoso B, Widjiati W.
europepmc +2 more sources
Nuclear Export of Cyclin B Mediated by the Nup62 Complex Is Required for Meiotic Initiation in Drosophila Males. [PDF]
Cells, 2020 Background: The central channel of the nuclear pore complex plays an important role in the selective transport of proteins between the nucleus and cytoplasm.
Okazaki R, Yamazoe K, Inoue YH.
europepmc +2 more sources
Recombinant cyclin B-Cdk1-Suc1 capable of multi-site mitotic phosphorylation in vitro. [PDF]
PLoS OneCyclin-dependent kinase 1 (Cdk1) complexed with cyclin B phosphorylates multiple sites on hundreds of proteins during mitosis. However, it is not fully understood how multi-site mitotic phosphorylation by cyclin B-Cdk1 controls the structures and ...
Shintomi K +4 more
europepmc +2 more sources
Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit. [PDF]
Elife, 2020 APC/C-mediated proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-counteracting phosphatases PP1 and PP2A-B55 ...
Holder J, Mohammed S, Barr FA.
europepmc +2 more sources
The 3' untranslated region of the cyclin B mRNA is not sufficient to enhance the synthesis of cyclin B during a mitotic block in human cells. [PDF]
PLoS One, 2013 Antimitotic agents are frequently used to treat solid tumors and hematologic malignancies. However, one major limitation of antimitotic approaches is mitotic slippage, which is driven by slow degradation of cyclin B during a mitotic block.
Schnerch D +4 more
europepmc +2 more sources
Cyclin B Translation Depends on mTOR Activity after Fertilization in Sea Urchin Embryos. [PDF]
PLoS ONE, 2016 The cyclin B/CDK1 complex is a key regulator of mitotic entry. Using PP242, a specific ATP-competitive inhibitor of mTOR kinase, we provide evidence that the mTOR signalling pathway controls cyclin B mRNA translation following fertilization in ...
Héloïse Chassé +5 more
doaj +1 more source
Activation of human B-MYB by cyclins [PDF]
Proceedings of the National Academy of Sciences, 1997 B-MYB expression is associated with cell proliferation and recent studies have suggested that it promotes the S phase of mammalian cells. Based on its homology to the transcription factors c-MYB and A-MYB, B-MYB is thought to be involved in transcriptional regulation; however, its activity is not detectable in several cell lines ...
Sala A +10 more
openaire +4 more sources
Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells
Cell Reports, 2020 Summary: Germinal center (GC) B cells surge in their proliferative capacity, which poses a direct risk for B cell malignancies. G1- to S-phase transition is dependent on the expression and stability of D-type cyclins.
Parham Ramezani-Rad +3 more
doaj +1 more source