Results 21 to 30 of about 222,589 (257)
Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity. [PDF]
PLoS ONE, 2012 Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase ...
Yee-Fun Su +4 more
doaj +1 more source
Specialization and Targeting of B-Type Cyclins [PDF]
Molecular Cell, 1999 The B-type cyclins of S. cerevisiae are diversified with respect to time of expression during the cell cycle as well as biological function. We replaced the early-expressed CLB5 coding sequence with the late-expressed CLB2 coding sequence, at the CLB5 locus.
Cross, Frederick R +3 more
openaire +2 more sources
A data-driven, mathematical model of mammalian cell cycle regulation. [PDF]
PLoS ONE, 2014 Few of >150 published cell cycle modeling efforts use significant levels of data for tuning and validation. This reflects the difficultly to generate correlated quantitative data, and it points out a critical uncertainty in modeling efforts. To develop a
Michael C Weis +3 more
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Cyclin B and Cyclin A Confer Different Substrate Recognition Properties on CDK2 [PDF]
Cell Cycle, 2007 The transitions of the cell cycle are regulated by the cyclin dependent protein kinases (CDKs). The cyclins activate their respective CDKs and confer substrate recognition properties. We report the structure of phospho-CDK2/cyclin B and show that cyclin B confers M phase-like properties on CDK2, the kinase that is usually associated with S phase ...
Brown, N. R. +5 more
openaire +3 more sources
PP2A function toward mitotic kinases and substrates during [PDF]
BMB Reports, 2013 To maintain cellular homeostasis against the demands of theextracellular environment, a precise regulation of kinases andphosphatases is essential. In cell cycle regulation mechanisms,activation of the cyclin-dependent kinase (CDK1) and cyclin Bcomplex ...
Ae Lee Jeong, Young Yang
doaj +1 more source
The Crystal Structure of Human Cyclin B [PDF]
Cell Cycle, 2007 Cyclin B is the key regulatory protein controlling mitosis in all eukaryotes, where it binds cyclin-dependent kinase, cdk1, forming a complex which initiates the mitotic program through phosphorylation of select proteins. Cyclin B regulates the activation, subcellular localization, and substrate specificity of cdk1, and destruction of cyclin B is ...
Edward T, Petri +4 more
openaire +2 more sources
Mip/LIN-9 Regulates the Expression of B-Myb and the Induction of Cyclin A, Cyclin B, and CDK1 [PDF]
Journal of Biological Chemistry, 2007 Members of the novel family of proteins that include Drosophila Mip130, Caenorhabditis elegans LIN-9, and mammalian LIN-9 intervene in different cellular functions such as regulation of transcription, differentiation, transformation, and cell cycle progression. Here we demonstrate that LIN-9, designated as Mip/LIN-9, interacts with B-Myb but not with c-
Mark, Pilkinton +4 more
openaire +2 more sources
Molecules, 2021 Recently, multitargeted drugs are considered a potential approach in treating cancer. In this study, twelve in-house indole-based derivatives were preliminary evaluated for their inhibitory activities over VEGFR-2, CDK-1/cyclin B and HER-2.
Ahmed Elkamhawy +6 more
doaj +1 more source
The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. [PDF]
The EMBO Journal, 1994 We have shown previously that human cyclins A and B1 are localized differentially in the cell during interphase; cyclin A is nuclear and cyclin B1 is a cytoplasmic protein. To understand the basis of this difference we created deletion mutants and various chimeras between the two types of cyclin and expressed them in tissue culture cells by transient ...
J, Pines, T, Hunter
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Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells
Cell Death Discovery, 2021 Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma.
Ariadna Recasens +13 more
doaj +1 more source