Determinants of human cyclin B1 association with mitotic chromosomes. [PDF]
PLoS ONE, 2013 Cyclin B1-CDK1 activity is essential for mitotic entry, but questions remain regarding how the activity of this kinase is spatially regulated. Previous studies showed that the cyclin B1 subunit localizes to several compartments of a mitotic cell ...
Kathleen L Pfaff, Randall W King
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Cell cycle-related cyclin b1 quantification. [PDF]
PLoS ONE, 2009 To obtain non-relative measures of cell proteins, purified preparations of the same proteins are used as standards in Western blots. We have previously quantified SV40 large T antigen expressed over a several fold range in different cell lines and ...
Phyllis S Frisa, James W Jacobberger
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Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol [PDF]
BMC Cancer, 2008 Background Cyclin B1, the regulatory subunit of cyclin-dependent kinase 1 (Cdk1), is essential for the transition from G2 phase to mitosis. Cyclin B1 is very often found to be overexpressed in primary breast and cervical cancer cells as well as in cancer
Strebhardt Klaus +7 more
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USP39-mediated deubiquitination of Cyclin B1 promotes tumor cell proliferation and glioma progression [PDF]
Translational Oncology, 2023 Background: The elevated Cyclin B1 expression contributes to various tumorigenesis and poor prognosis. Cyclin B1 expression could be regulated by ubiquitination and deubiquitination.
Yue Xiao +8 more
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PTBP1 promotes IRES-mediated translation of cyclin B1in cancer [PDF]
Acta Biochimica et Biophysica Sinica, 2022 Cyclin B1 is an essential cyclin-dependent protein that involves in the G2/M transition. Multiple studies report that cyclin B1 is upregulated in cancers and promotes cancer progression.
Fan Xinyi +5 more
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MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C [PDF]
Biology Open, 2015 When cells enter mitosis, the anaphase-promoting complex/cyclosome (APC/C) is activated by phosphorylation and binding of Cdc20. The RXXL destruction box (D-box) of cyclin B1 only binds Cdc20 after release of the spindle checkpoint in metaphase ...
Erik Voets, Rob Wolthuis
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Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]
PLoS ONE, 2010 The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Danupon Nantajit +5 more
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Initial activation of cyclin‐B1–cdc2 kinase requires phosphorylation of cyclin B1 [PDF]
EMBO reports, 2002 At the G2/M transition of the cell cycle, the cdc25c phosphatase dephosphorylates inhibitory residues of cdc2, and cyclin‐B–cdc2 kinase (MPF) is activated. Phosphorylation of cyclin B1 induces its nuclear accumulation, and, since cdc25c is also believed to accumulate and activate shortly before G2/M in the nucleus, it has been proposed that this ...
Marion Peter +5 more
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Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. [PDF]
PLoS ONE, 2011 During a normal cell cycle, the transition from G₂ phase to mitotic phase is triggered by the activation of the cyclin B1-dependent Cdc2 kinase. Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic ...
Hye Joung Choi +2 more
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Over‐expression of FoxM1 stimulates cyclin B1 expression [PDF]
FEBS Letters, 2001 FoxM1 (previously named WIN, HFH‐11 or Trident) is a Forkhead box (Fox) transcription factor widely expressed in proliferating cells. Various findings, including a recent analysis of FoxM1 knockout mice, suggest that FoxM1 is required for normal S–M coupling during cell cycle progression.
Tommy W.C. Leung +8 more
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