Determinants of human cyclin B1 association with mitotic chromosomes. [PDF]
PLoS ONE, 2013 Cyclin B1-CDK1 activity is essential for mitotic entry, but questions remain regarding how the activity of this kinase is spatially regulated. Previous studies showed that the cyclin B1 subunit localizes to several compartments of a mitotic cell ...
Kathleen L Pfaff, Randall W King
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Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy [PDF]
Open Biology, 2022 Measuring the dynamics with which the regulatory complexes assemble and disassemble is a crucial barrier to our understanding of how the cell cycle is controlled that until now has been difficult to address.
Martina Barbiero +5 more
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Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]
PLoS ONE, 2010 The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Danupon Nantajit +5 more
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USP39-mediated deubiquitination of Cyclin B1 promotes tumor cell proliferation and glioma progression [PDF]
Translational Oncology, 2023 Background: The elevated Cyclin B1 expression contributes to various tumorigenesis and poor prognosis. Cyclin B1 expression could be regulated by ubiquitination and deubiquitination.
Yue Xiao +8 more
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PTBP1 promotes IRES-mediated translation of cyclin B1in cancer [PDF]
Acta Biochimica et Biophysica Sinica, 2022 Cyclin B1 is an essential cyclin-dependent protein that involves in the G2/M transition. Multiple studies report that cyclin B1 is upregulated in cancers and promotes cancer progression.
Fan Xinyi +5 more
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Positively charged specificity site in cyclin B1 is essential for mitotic fidelity [PDF]
Nature CommunicationsPhosphorylation of substrates by cyclin-dependent kinases (CDKs) is the driving force of cell cycle progression. Several CDK-activating cyclins are involved, yet how they contribute to substrate specificity is still poorly understood.
Christian Heinzle +9 more
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Effect of demecolcine-assisted enucleation on the MPF level and cyclin B1 distribution in porcine oocytes. [PDF]
PLoS ONE, 2014 Demecolcine (DEM) treatment of oocytes induces formation of a membrane protrusion containing a mass of condensed maternal chromosomes, which can be removed with minimal damage prior to somatic cell nuclear transfer (SCNT).
Suo Li +10 more
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Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis [PDF]
Renal FailurePodocyte loss in glomeruli is a fundamental event in the pathogenesis of chronic kidney diseases. Currently, mitotic catastrophe (MC) has emerged as the main cause of podocyte loss. However, the regulation of MC in podocytes has yet to be elucidated. The
Jie Feng +6 more
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Two mechanisms repress cyclin B1 translation to maintain prophase arrest in mouse oocytes [PDF]
Nature CommunicationsIn mammals, oocytes are arrested in prophase of meiosis I for long periods of time. Prophase arrest is critical for reproduction because it allows oocytes to grow to their full size to support meiotic maturation and embryonic development. Prophase arrest
Shiya Cheng, Melina Schuh
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Macrophages maintain mammary stem cell activity and mammary homeostasis via TNF-α-PI3K-Cdk1/Cyclin B1 axis. [PDF]
NPJ Regen Med, 2023 Zhou Y +6 more
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