Results 1 to 10 of about 34,307 (136)

USP39-mediated deubiquitination of Cyclin B1 promotes tumor cell proliferation and glioma progression [PDF]

Translational Oncology, 2023
Background: The elevated Cyclin B1 expression contributes to various tumorigenesis and poor prognosis. Cyclin B1 expression could be regulated by ubiquitination and deubiquitination.
Yue Xiao, Xinyi Chen, Weiwei Hu, Wenjing Ma, Qianqian Di, Haimei Tang, Xibao Zhao, Guodong Huang, Weilin Chen   +8 more
doaj   +2 more sources

PTBP1 promotes IRES-mediated translation of cyclin B1in cancer [PDF]

Acta Biochimica et Biophysica Sinica, 2022
Cyclin B1 is an essential cyclin-dependent protein that involves in the G2/M transition. Multiple studies report that cyclin B1 is upregulated in cancers and promotes cancer progression.
Fan Xinyi, Zhao Zitong, Ma Liying, Huang Xuanlin, Zhan Qimin, Song Yongmei   +5 more
doaj   +2 more sources

Cell cycle-related cyclin b1 quantification. [PDF]

PLoS ONE, 2009
To obtain non-relative measures of cell proteins, purified preparations of the same proteins are used as standards in Western blots. We have previously quantified SV40 large T antigen expressed over a several fold range in different cell lines and ...
Phyllis S Frisa, James W Jacobberger
doaj   +4 more sources

MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C [PDF]

Biology Open, 2015
When cells enter mitosis, the anaphase-promoting complex/cyclosome (APC/C) is activated by phosphorylation and binding of Cdc20. The RXXL destruction box (D-box) of cyclin B1 only binds Cdc20 after release of the spindle checkpoint in metaphase ...
Erik Voets, Rob Wolthuis
doaj   +5 more sources

Spatial control of the APC/C ensures the rapid degradation of cyclin B1 [PDF]

The EMBO Journal
The proper control of mitosis depends on the ubiquitin-mediated degradation of the right mitotic regulator at the right time. This is effected by the Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase that is regulated by the Spindle Assembly ...
Luca Cirillo, Rose Young, Sapthaswaran Veerapathiran, Annalisa Roberti, Molly Martin, Azzah Abubacar, Camilla Perosa, Catherine Coates, Reyhan Muhammad, Theodoros I Roumeliotis, Jyoti S Choudhary, Claudio Alfieri, Jonathon Pines   +12 more
doaj   +2 more sources

CDK5-cyclin B1 regulates mitotic fidelity. [PDF]

Nature
CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression1. Here we demonstrate that CDK5 is active during mitosis and is necessary for maintaining mitotic fidelity. CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392 ...
Zheng XF, Sarkar A, Lotana H, Syed A, Nguyen H, Ivey RG, Kennedy JJ, Whiteaker JR, Tomasik B, Huang K, Li F, D'Andrea AD, Paulovich AG, Shah K, Spektor A, Chowdhury D.   +15 more
europepmc   +3 more sources

Determinants of human cyclin B1 association with mitotic chromosomes. [PDF]

PLoS ONE, 2013
Cyclin B1-CDK1 activity is essential for mitotic entry, but questions remain regarding how the activity of this kinase is spatially regulated. Previous studies showed that the cyclin B1 subunit localizes to several compartments of a mitotic cell ...
Kathleen L Pfaff, Randall W King
doaj   +5 more sources

Positively charged specificity site in cyclin B1 is essential for mitotic fidelity [PDF]

Nature Communications
Phosphorylation of substrates by cyclin-dependent kinases (CDKs) is the driving force of cell cycle progression. Several CDK-activating cyclins are involved, yet how they contribute to substrate specificity is still poorly understood.
Christian Heinzle, Anna Höfler, Jun Yu, Peter Heid, Nora Kremer, Rebecca Schunk, Florian Stengel, Tanja Bange, Andreas Boland, Thomas U. Mayer   +9 more
doaj   +3 more sources

Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis [PDF]

Renal Failure
Podocyte loss in glomeruli is a fundamental event in the pathogenesis of chronic kidney diseases. Currently, mitotic catastrophe (MC) has emerged as the main cause of podocyte loss. However, the regulation of MC in podocytes has yet to be elucidated. The
Jie Feng, Liyi Xie, Wanhong Lu, Xiaoyang Yu, Hongjuan Dong, Yuefeng Ma, Ranran Kong   +6 more
doaj   +2 more sources

Copper is essential for cyclin B1-mediated CDK1 activation. [PDF]

Nat Commun
Cyclin-dependent kinase 1 (CDK1) is the pivotal kinase responsible for initiating cell division. Its activation is dependent on binding to regulatory cyclins, such as CCNB1. Our research demonstrates that copper binding to both CDK1 and CCNB1 is essential for activating CDK1 in cells.
Wang J, Yang D, Yu HF, Jin J, Nie Y, Zhang S, Ren W, Ge Z, Zhang Z, Ma X, Dai S, Sui G, Teng CB.   +12 more
europepmc   +4 more sources