Results 101 to 110 of about 63,908 (269)

A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan [PDF]

, 2008
A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent ...
Ali, Reza, Campbell, L., Chappell, M. J. (Michael J.), Errington, Rachel J., Evans, Neil D., Godfrey, Keith, Khan, I. A., Smith, Paul J.   +7 more
core   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Cyclin A2 Is Required for Sister Chromatid Segregation, But Not Separase Control, in Mouse Oocyte Meiosis

Cell Reports, 2012
In meiosis, two specialized cell divisions allow the separation of paired chromosomes first, then of sister chromatids. Separase removes the cohesin complex holding sister chromatids together in a stepwise manner from chromosome arms in meiosis I, then ...
Sandra A. Touati, Damien Cladière, Lisa M. Lister, Ioanna Leontiou, Jean-Philippe Chambon, Ahmed Rattani, Franziska Böttger, Olaf Stemmann, Kim Nasmyth, Mary Herbert, Katja Wassmann   +10 more
doaj   +1 more source

CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells. [PDF]

PLoS ONE, 2011
C-C chemokine receptor 7 (CCR7) contributes to the survival of certain cancer cell lines, but its role in the proliferation of human non-small cell lung cancer (NSCLC) cells remains vague. Proliferation assays performed on A549 and H460 NSCLC cells using
Ying Xu, Lifeng Liu, Xueshan Qiu, Lili Jiang, Bo Huang, Haiying Li, Zixuan Li, Wenting Luo, Enhua Wang   +8 more
doaj   +1 more source

Macromolecular High‐Affinity Binding Probed by Advanced Fluorescence Techniques

ChemBioChem, Accepted Article.
Due to the extreme sensitivity and the intrinsic selectivity of fluorescence techniques, high‐affinity binding can be measured even at extremely low molecule concentrations in the picomolar range. In particular, modern advanced techniques with fluorescence microscopes have provided considerable methodological advancements in recent years.
Alida Meyer, Benno Schedler, Joerg Fitter   +2 more
wiley   +1 more source

Cyclin B1: Abnormal Self/Tumor Antigen [PDF]

, 2008
We previously identified the aberrantly expressed cell cycle regulator cyclin B1 as a tumor antigen that can elicit both humoral and cellular immune responses in cancer patients.
Vella, Laura Ann
core  

Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase [PDF]

, 2014
Fidelity of chromosome segregation is monitored by the spindle assembly checkpoint (SAC). Key components of the SAC include MAD1, MAD2, BUB1, BUB3, BUBR1, and MPS1.
A Antoni De, A Kulukian, A Musacchio, A Teichner, Adrian T. Saurin, AE Dick, AR Tipton, B Pinsky, BJ Howell, BJ Howell, C Ditchfield, C Klebig, CJ Morrow, DA Skoufias, DM Brady, E Wojcik, EMJ King, F Herzog, FG Westhorpe, G Fang, G Varetti, Geert J. P. L. Kops, GJPL Kops, GJPL Kops, GK Chan, J Davenport, J Maciejowski, J Mansfeld, J Pines, JC Waters, JK Famulski, JK Famulski, JL Burton, JM Sheltzer, JS Han, JS Rosenberg, K Uzunova, L Sironi, M Barisic, M Maldonado, M Mapelli, M Sczaniecka, M Simonetta, M Vleugel, Manja Omerzu, MW Moyle, N Jelluma, N London, P Clute, P Collin, P Lara-Gonzalez, R Basto, R Gassmann, S Elowe, S Hauf, S Kim, S Martin-Lluesma, S Santaguida, SA Foster, SK Reddy, SS Taylor, ST Liu, T Sliedrecht, Timo E. F. Kuijt, V Sudakin, V Vanoosthuyse, VM Rivera, WCH Chao, Z Tang, Z Yang   +69 more
core   +2 more sources

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

SUMOylation inhibits FOXM1 activity and delays mitotic transition [PDF]

, 2014
The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but
Brosens, Jan J., Coombes, R. C., Dunsby, C. W., French, P. M., Gomes, Ana R., Karunarathna, U., Kelly, D. J., Khongkow, P., Kongsema, M., Lam, Eric W.-F., Langer, J. K., Man, Cornelia W-Y., Myatt, Stephen S., Zona, Stefania   +13 more
core   +1 more source

Applications of bioactive herbal extracts in dressing materials for skin wound repair: Ingredients, mechanisms and innovations

Interdisciplinary Medicine, EarlyView.
Abstract The skin, as the body's largest organ, plays essential roles in protection, immune regulation, and homeostasis. Skin trauma, especially chronic wounds such as diabetic ulcers, poses significant clinical challenges. Traditional treatments, while often effective, can be costly and pose risks.
Boxiang Yang, Jingyuan Xu, Siyi Liu, Chaoying Wu, Yi Li, Mingqi Lv, Tingting Chen, Chuanrong Zhao, Daojun Pu, Chaojun Tang, Anna Malashicheva, Guangchao Zang, Guixue Wang   +12 more
wiley   +1 more source