Results 111 to 120 of about 63,908 (269)

Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exit.

PLoS ONE, 2007
M-phase Promoting Factor (MPF; the cyclin B-cdk 1 complex) is activated at M-phase onset by removal of inhibitory phosphorylation of cdk1 at thr-14 and tyr-15. At M-phase exit, MPF is destroyed by ubiquitin-dependent cyclin proteolysis.
Vincenzo D'Angiolella, Luca Palazzo, Concetta Santarpia, Vincenzo Costanzo, Domenico Grieco   +4 more
doaj   +1 more source

Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses. [PDF]

Mitosis in early embryos often proceeds at a rapid pace, but how this pace is achieved is not understood. Here, we show that cyclin B3 is the dominant driver of rapid embryonic mitoses in the C. elegans embryo.
Bardwell, Lee, Bellaart, Andrew, Budrewicz, Jacqueline, Desai, Arshad, Kizhedathu, Amrutha, Lara-Gonzalez, Pablo, Moghareh, Shabnam, Nguyen, Anh, Oegema, Karen, Schlientz, Aleesa, Variyar, Smriti, Varshney, Neha   +11 more
core   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

M2I-1 disrupts the in vivo interaction between CDC20 and MAD2 and increases the sensitivities of cancer cell lines to anti-mitotic drugs via MCL-1s [PDF]

, 2019
Background Drugs such as taxanes, epothilones, and vinca alkaloids are widely used in the treatment of breast, ovarian, and lung cancers but come with major side effects such as neuropathy and loss of neutrophils and as single agents have a lack of ...
Dang, Nanmao, Gao, Fei, Huang, Dong, Huang, Jun-Yong, Jowsey, Paul, Li, Jianquan, Lightowlers, Robert N., Martinez-Lopez, Nuria   +7 more
core   +1 more source

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition &Food Research, EarlyView.
Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Graziella Marino, Marisabel Mecca   +4 more
wiley   +1 more source

Immortal, non‐tumourigenic mouse mammary outgrowths express high levels of cyclin B1 and activation of cyclin B1/cdc2 kinase

Cell Proliferation, 1996
Abstract. Neoplastic transformation of mouse mammary epithelial cells is the result of several identifiable phenotypic changes which presumably require sequential genetic alterations. In our model system, mammary cells progress from a mortal state (virgin duct) to several morphologically distinct intermediate states.
Daniel Medina, S. Bonnette, T. K. Said
openaire   +3 more sources

PD‐L1 Expression is Mediated by microRNA Processing, Wnt/β‐Catenin Signaling, and Chemotherapy in Wilms Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Inhibition of immune checkpoint proteins is effective in adult cancers but has shown limited efficacy in pediatric cancers. While factors regulating expression of immune checkpoint proteins such as PD‐L1 are well documented in adult cancers, their regulation is poorly understood in pediatric cancers.
Patricia D. B. Tiburcio, Kavita Desai, Austin Warne, Arash Nabbi, Serena Zhou, Sean D. Reiff, Matthew E. Campbell, James F. Amatruda, Kenneth S. Chen   +8 more
wiley   +1 more source

Sodium selenite alters microtubule assembly and induces apoptosis in vitro and in vivo

Journal of Hematology & Oncology, 2013
Background Previous studies demonstrated that selenite induced cancer-cell apoptosis through multiple mechanisms; however, effects of selenite on microtubules in leukemic cells have not been demonstrated.
Shi Kejian, Jiang Qian, Li Zhushi, Shan Lei, Li Feng, An JiaJia, Yang Yang, Xu Caimin   +7 more
doaj   +1 more source

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

Small Methods, EarlyView.
This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta, Dongjun Shin, Hyun Sung Park, Jun Su An, Seong Il Lim, Hyun Jin Kim, Seungpyo Hong, Jiyoon Bu   +7 more
wiley   +1 more source

MicroRNA-125b controls growth of ovarian granulosa cells in polycystic ovarian syndrome by modulating cyclin B1 expression

Archives of Medical Science, 2019
Introduction There is a lot of evidence that suggests that microRNAs (miRs) play an imperative role in the pathogenesis of polycystic ovary syndrome (PCOS). This study was designed to decipher the role of miR-125b in PCOS pathogenesis.
Jie Deng, Chanyu Li, Jianbo Luo, Jiaqiong Xie, Cong Peng, Xiaoyang Deng   +5 more
doaj   +1 more source