Results 121 to 130 of about 34,398 (227)
Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation. [PDF]
J Cell Biol, 2022 Dantas M +4 more
europepmc +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, Volume 20, Issue 3, Page 727-752, March 2026.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Nuclear-cytoplasmic compartmentalization of cyclin B1-Cdk1 promotes robust timing of mitotic events. [PDF]
Cell Rep, 2022 Maryu G, Yang Q.
europepmc +1 more source
Expression der Zellzyklusregulatorgene Cyclin A, Cyclin B1, p16 und cdk2 beim Ovarialkarzinom
, 2011 Ovarian cancer is the 6th most common malignant tumor among women and the leading cause of death due to genital malignancies in the western hemisphere. As early symptoms are lacking and screening is not available the diagnose is usually found in advanced stages of the disease.
openaire +1 more source
Molecular Oncology, Volume 20, Issue 3, Page 637-667, March 2026.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Novel Therapeutic Combination Targets the Growth of Letrozole-Resistant Breast Cancer through Decreased Cyclin B1. [PDF]
Nutrients, 2023 Patel JR +6 more
europepmc +1 more source
Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu +4 more
wiley +1 more source
Hydrogen Peroxide Mediates Pharmacological Ascorbate Induced Radio-Sensitization of Pancreatic Cancer Cells by Enhancing G2-accumulation and Reducing Cyclin B1 Protein Levels. [PDF]
Radiat Res, 2023 O'Leary BR +4 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao +3 more
wiley +1 more source
Knockout of cyclin B1 in granulosa cells causes female subfertility. [PDF]
Cell Cycle, 2022 Cheng J, Liu Y.
europepmc +1 more source