Results 131 to 140 of about 63,908 (269)

BubR1 Insufficiency Drives Transcriptomic Alterations and Pathology Associated With Cardiac Aging and Heart Failure

open access: yesAging Cell, EarlyView.
Transcriptomic and cellular analyses of BubR1 hypomorphic hearts reveal disruptions in key pathways and upregulation of markers linked to impaired cardiac structure and function. Comparative transcriptomic analysis shows that BubR1 insufficiency mirrors changes seen in aged and failing hearts. A key finding of this study is that BubR1 levels decline in
Renju Pun   +13 more
wiley   +1 more source

Spliceosome protein alterations differentiate hubs of the default mode connectome during the progression of Alzheimer's disease

open access: yesBrain Pathology, EarlyView.
Default mode network (DMN) consists, in part, of the frontal (FC), precuneus (PreC), and posterior cingulate cortex (PCC), which plays a critical role in episodic memory and retrieval of autobiographical memories, displays spatiotemporal differences in the onset of amyloid and hypometabolism that reflects tau neurodegeneration and loss of connectivity ...
Sylvia E. Perez   +8 more
wiley   +1 more source

A single cyclin A gene and multiple cyclin B1-related sequences are dispersed in the mouse genome

open access: yesGenomics, 1992
Cyclin activation of protein serine/threonine kinases plays a pivotal role in regulating the cell cycle. Multiple cyclins that fall into at least five classes, A, B, C, D, and E, have been identified. In some organisms, more than one member of a single cyclin class has been observed.
Neal G. Copeland   +7 more
openaire   +3 more sources

KLHL5 Contributes to Colorectal Cancer Cell Survival by Promoting Cell Cycle Progression and Suppressing Apoptotic Cell Death

open access: yesCancer Science, EarlyView.
Bioinformatic analysis of 42 KLHL family genes identified KLHL5 as a potential prognostic biomarker for colorectal cancer (CRC), with higher expression in the common molecular subtype (CMS) 4 CRC, which is characterized by poorer overall and recurrence‐free survival rates compared to other CMS groups. KLHL5 immunohistochemical analysis was performed on
Kyosuke Habu   +15 more
wiley   +1 more source

PBK Expression Promotes the Aggressive Phenotypes of Mesothelioma

open access: yesCancer Science, EarlyView.
PBK plays a crucial role in cell survival in mesothelioma and is associated with worse outcome. PBK is a promising therapeutic target that may serve as a prognostic biomarker, enabling personalized treatment of mesothelioma. ABSTRACT Mesothelioma is one of the most aggressive neoplasms worldwide that has a particularly poor prognosis.
Kazumi Hori   +12 more
wiley   +1 more source

Evaluation of serum autoantibodies against tumor-associated antigens as biomarkers in lung cancer

open access: yesTumor Biology, 2017
We evaluated autoantibodies against nine tumor-associated antigens, including p62, p16, Koc, p53, Cyclin B1, Cyclin E, Survivin, HCC1, and RalA as serological markers in lung cancer.
Pei Li   +5 more
doaj   +1 more source

Epigenetically‐Upregulated CD98 Shed Light on the Precancerous Diagnosis and Prognosis Prediction of Esophageal Cancer

open access: yesCancer Science, EarlyView.
This study confirmed that hypomethylation‐induced upregulation of CD98 promoted ESCC cell proliferation by regulating the cell cycle and was correlated with poorer overall survival of ESCC patients. Combined panels of immunohistochemistry (CD98 and P53) are recommended for accurate diagnosis of esophageal precancerous lesions.
Xue Zhang   +13 more
wiley   +1 more source

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