Results 141 to 150 of about 63,908 (269)

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

Cell Proliferation, EarlyView.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu, Jinming Liu, Jian Tu, Min Yang, Qisheng He, Fei Li, Xiaojing Xu, Zhongqing Ji, Jianwei Xu, Wentao Zhong, Mengwen Yan, Ying Yang, Huanxiang Zhang   +12 more
wiley   +1 more source

Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors

Experimental and Molecular Medicine, 2018
Breast cancer: A protein link for treatment? The role of disrupted activity of the protein BRCA1 in the progression of breast cancer has been clarified, suggesting that targeting another protein with which it interacts could offer a new route to ...
Eun Kyung Choi, Jeong-A Lim, Jong Kwang Kim, Moon Sun Jang, Sun Eui Kim, Hye Jung Baek, Eun Jung Park, Tae Hyun Kim, Chu-Xia Deng, Rui-Hong Wang, Sang Soo Kim   +10 more
doaj   +1 more source

Intracellular localization of cyclin B1 during the cell cycle in glioma cells [PDF]

, 1996
Shunsuke Kakino, Kohsuke Sasaki, Akira Kurose, Haruhide Ito   +3 more
openalex   +1 more source

Exploring the Single‐Cell Dynamics of FOXM1 Under Cell Cycle Perturbations

Cell Proliferation, EarlyView.
The varied FOXM1 dynamic patterns reveal significant differences in cellular responses to the same stimuli at the single‐cell level. This emphasises the relationship between cue, signal and response as influenced by different drug types and concentrations.
Tooba Jawwad, Maliwan Kamkaew, Kriengkrai Phongkitkarun, Porncheera Chusorn, Supawan Jamnongsong, Eric W.‐F. Lam, Somponnat Sampattavanich   +6 more
wiley   +1 more source

A potential mechanism for fumonisin B1-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3β activity [PDF]

, 2000
Danica Ramljak, Richard J. Calvert, Paddy Wiesenfeld, Bhalchandra A. Diwan, Branimir Čatipović, Walter F. O. Marasas, Tommie C. Victor, Lucy M. Anderson, Wentzel C.A. Gelderblom   +8 more
openalex   +1 more source

High cyclin B1 expression is associated with poor survival in breast cancer [PDF]

Cyclin B1 regulates the G2-M transition of the cell cycle. Cyclin B1 expression is higher in premalignant and malignant than normal breast lesions. Correlation of cyclin B1 expression with other histopathological variables and prognostic role in breast ...
A Tamminen, A Volpi, C Ahlin, C Blomqvist, CJ Sherr, CW Elston, H Eerola, H Eerola, H Joensuu, H Kawamoto, H Kühling, H Lassus, H Murakami, H Nevanlinna, J Bryant, J Pines, J Tommiska, JC Soria, JF Simpson, K Aaltonen, K Aaltonen, K Aittomäki, K Syrjäkoski, LJ Van’t Veer, M Buyse, M Shen, M Tanner, MG Peters, MJ van de Vijver, MP Look, O Kilpivaara, P Dettmar, P Heikkilä, P Rudolph, R Dent, R-M Amini, RC Bast, S Paik, S Takeno, SA Innocente, SO Ikuerowo, T Nozoe, T Suzuki, T Yoshida, ZE Winters   +44 more
core   +2 more sources

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, EarlyView.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

A pancancer analysis of the oncogenic role of cyclin B1 (CCNB1) in human tumors. [PDF]

Sci Rep, 2023
Dai P, Xiong L, Wei Y, Wei X, Zhou X, Zhao J, Tang H.   +6 more
europepmc   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source