Results 141 to 150 of about 34,398 (227)

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Anaphase onset requires CKS-1-mediated destruction of securin in meiosis I and cyclin B1 in meiosis II. [PDF]

J Cell Biol
Yang J, Sumiyoshi E, Bowerman B.
europepmc   +1 more source

GPx3 knockdown inhibits the proliferation and DNA synthesis and enhances the early apoptosis of human spermatogonial stem cells via mediating CXCL10 and cyclin B1. [PDF]

Front Cell Dev Biol, 2023
Wu S, Cheng Z, Peng Y, Cao Y, He Z.
europepmc   +1 more source

FBXW7 Targets the SPT6‐ΔNp63 Axis for Degradation to Inhibit Esophageal Tumorigenesis Induced by 4‐Nitroquinoline N‐Oxide

MedComm, Volume 7, Issue 3, March 2026.
In normal cells, FBXW7 promotes ubiquitylation and degradation of SPT6 and ΔNp63 to keep their pro‐proliferative functions under control. During esophageal tumorigenesis, FBXW7 is inactivated by mutations or deletion, leading to the accumulation of SPT6 and ΔNp63, with ΔNp63 also being up‐regulated by SPT6.
Jiagui Zhang, Lu Yin, Xiahong You, Xiufang Xiong, Yi Sun   +4 more
wiley   +1 more source

The mechanism of luteolin suppressing pancreatic cancer (PC) via cyclin B1 (CCNB1)-mediated signalling. [PDF]

Sci Rep
Peng L, Guo X, Kong X, Zhang H, Liang Y, Zhang Q, Ren Z, Cui D.   +7 more
europepmc   +1 more source

G2/Mitotic-Specific Cyclin-B1 [PDF]

, 2020
openaire   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, Volume 2, Issue 1, Page 106-129, March 2026.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

LncRNA Wee1-AS coordinates oxidative fatty acid metabolism through the activation of mitochondrial CDK1/CYCLIN B1. [PDF]

Signal Transduct Target Ther
Kim HJ, Jeong C, Lee SH, An S, Hyun GH, Lim GY, Kim JY, Lee J, Park MJ, Kwon SW, Kim W, Noh M, Han YH, Lee MO.   +13 more
europepmc   +1 more source

Macrophages maintain mammary stem cell activity and mammary homeostasis via TNF-α-PI3K-Cdk1/Cyclin B1 axis. [PDF]

NPJ Regen Med, 2023
Zhou Y, Ye Z, Wei W, Zhang M, Huang F, Li J, Cai C.   +6 more
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source