Results 171 to 180 of about 63,908 (269)

Control of Cyclin B1 localization through regulated binding of the nuclear export factor CRM1

open access: gold, 1998
Jing Yang   +5 more
openalex   +1 more source

Mitochondrial DNA affects tau phosphorylation in aging and Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION Impaired mitochondrial function is seen in Alzheimer's disease (AD), but its role is unclear. Mitochondrial DNA (mtDNA) supports bioenergetic metabolism, but it is uncertain how it might influence AD neuropathology. METHODS We used cytoplasmic hybrid (cybrid) cell lines made from SH‐SY5Y cells expressing mtDNA from cognitively ...
Riley E. Kemna   +11 more
wiley   +1 more source

Compact Origins and Where to Find Them: ORC's Guide to Genome‐Wide Licensing

open access: yesBioEssays, Volume 47, Issue 7, July 2025.
Origin licensing is a key requirement for any eukaryotic cell to initiate DNA replication in S‐phase. Here, we review the most recent findings in the orchestrated action of the origin recognition complex (ORC) to sequentially load two MCM2‐7 helicases onto DNA with a focus on origin architecture and sequencing‐based methods.
Christian Speck   +1 more
wiley   +1 more source

SETDB2 interacts with BUBR1 to induce accurate chromosome segregation independently of its histone methyltransferase activity

open access: yesFEBS Open Bio
SETDB2 is a H3K9 histone methyltransferase required for accurate chromosome segregation. Its H3K9 histone methyltransferase activity was reported to be associated with chromosomes during metaphase. Here, we confirm that SETDB2 is required for mitosis and
Yanhong Tu   +7 more
doaj   +1 more source

Text Mining Strategy Identifies Gene Networks Under Control of miR‐21 in Breast Cancer Development

open access: yesCancer Medicine, Volume 14, Issue 13, July 2025.
ABSTRACT Background MicroRNAs (miRNAs) are small regulatory molecules that play a critical role in various biological processes by regulating gene expression. They have emerged as crucial players in cancer development, including breast cancer. However, individual research studies may be subject to specific biases.
Hong Ye, Yuyu Wu, Richard Tran, Jie Wang
wiley   +1 more source

The Role of Iron Chelation Therapy in Colorectal Cancer: A Systematic Review on Its Mechanisms and Therapeutic Potential

open access: yesCancer Medicine, Volume 14, Issue 13, July 2025.
Iron chelation is a promising yet underexplored strategy for colorectal cancer (CRC) treatment. Iron chelators have a dual role in inhibiting and potentially promoting cancer progression. Iron chelation affects key CRC pathways, including histone methylation, NDRG1 upregulation, Wnt/β‐catenin, and p53 modulation.
Gihani Vidanapathirana   +4 more
wiley   +1 more source

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