Control of Cyclin B1 localization through regulated binding of the nuclear export factor CRM1
Jing Yang+5 more
openalex +1 more source
Mitochondrial DNA affects tau phosphorylation in aging and Alzheimer's disease
Abstract INTRODUCTION Impaired mitochondrial function is seen in Alzheimer's disease (AD), but its role is unclear. Mitochondrial DNA (mtDNA) supports bioenergetic metabolism, but it is uncertain how it might influence AD neuropathology. METHODS We used cytoplasmic hybrid (cybrid) cell lines made from SH‐SY5Y cells expressing mtDNA from cognitively ...
Riley E. Kemna+11 more
wiley +1 more source
Phosphorylation of VP1 Mediated by CDK1-Cyclin B1 Facilitates Infectious Bursal Disease Virus Replication. [PDF]
Hu X+7 more
europepmc +1 more source
Compact Origins and Where to Find Them: ORC's Guide to Genome‐Wide Licensing
Origin licensing is a key requirement for any eukaryotic cell to initiate DNA replication in S‐phase. Here, we review the most recent findings in the orchestrated action of the origin recognition complex (ORC) to sequentially load two MCM2‐7 helicases onto DNA with a focus on origin architecture and sequencing‐based methods.
Christian Speck+1 more
wiley +1 more source
SETDB2 is a H3K9 histone methyltransferase required for accurate chromosome segregation. Its H3K9 histone methyltransferase activity was reported to be associated with chromosomes during metaphase. Here, we confirm that SETDB2 is required for mitosis and
Yanhong Tu+7 more
doaj +1 more source
Knockout of cyclin B1 in granulosa cells causes female subfertility. [PDF]
Cheng J, Liu Y.
europepmc +1 more source
Text Mining Strategy Identifies Gene Networks Under Control of miR‐21 in Breast Cancer Development
ABSTRACT Background MicroRNAs (miRNAs) are small regulatory molecules that play a critical role in various biological processes by regulating gene expression. They have emerged as crucial players in cancer development, including breast cancer. However, individual research studies may be subject to specific biases.
Hong Ye, Yuyu Wu, Richard Tran, Jie Wang
wiley +1 more source
HN1 Is Enriched in the S-Phase, Phosphorylated in Mitosis, and Contributes to Cyclin B1 Degradation in Prostate Cancer Cells. [PDF]
Javed A+4 more
europepmc +1 more source
Biochemical Identification of Xenopus Pumilio as a Sequence-specific Cyclin B1 mRNA-binding Protein That Physically Interacts with a Nanos Homolog, Xcat-2, and a Cytoplasmic Polyadenylation Element-binding Protein [PDF]
Shingo Nakahata+5 more
openalex +1 more source
Iron chelation is a promising yet underexplored strategy for colorectal cancer (CRC) treatment. Iron chelators have a dual role in inhibiting and potentially promoting cancer progression. Iron chelation affects key CRC pathways, including histone methylation, NDRG1 upregulation, Wnt/β‐catenin, and p53 modulation.
Gihani Vidanapathirana+4 more
wiley +1 more source