Two mechanisms repress cyclin B1 translation to maintain prophase arrest in mouse oocytes [PDF]
Nature CommunicationsIn mammals, oocytes are arrested in prophase of meiosis I for long periods of time. Prophase arrest is critical for reproduction because it allows oocytes to grow to their full size to support meiotic maturation and embryonic development. Prophase arrest
Shiya Cheng, Melina Schuh
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Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy [PDF]
Open Biology, 2022 Measuring the dynamics with which the regulatory complexes assemble and disassemble is a crucial barrier to our understanding of how the cell cycle is controlled that until now has been difficult to address.
Martina Barbiero +5 more
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Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression. [PDF]
PLoS Biology, 2007 Activation of cyclin B1-cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key event that initiates mitotic entry.
Arne Lindqvist +3 more
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Cyclin b1 suppresses colorectal cancer invasion and metastasis by regulating e-cadherin. [PDF]
PLoS ONE, 2015 Cyclin B1, a mitotic cyclin, has been implicated in malignances. However, its contribution to colorectal cancer invasion and metastasis are still not well understood.
Yifeng Fang +5 more
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Immunohistochemical Expression of Cyclin B1 in Epithelial Hyperplasia, Dysplasia and Oral Squamous Cell Carcinomas - A Comparative Study [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Cyclin B1 is important in the cell cycle progression from G2 to M phase. Cyclin B1 binds to CDC2, which then becomes dephosphorylated and gets relocated to the nucleus, ensuring the transition toward mitosis.
Kochli Channappa Niranjan +5 more
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Initial activation of cyclin‐B1–cdc2 kinase requires phosphorylation of cyclin B1 [PDF]
EMBO reports, 2002 At the G 2 /M transition of the cell cycle, the cdc25c phosphatase dephosphorylates inhibitory residues of cdc2, and cyclin‐B–cdc2 kinase (MPF) is activated. Phosphorylation of cyclin B1 induces its nuclear accumulation, and, since cdc25c is also believed to accumulate and activate shortly ...
Marion, Peter +5 more
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Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. [PDF]
PLoS ONE, 2011 During a normal cell cycle, the transition from G₂ phase to mitotic phase is triggered by the activation of the cyclin B1-dependent Cdc2 kinase. Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic ...
Hye Joung Choi +2 more
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Expression of CDK1(Tyr15), pCDK1(Thr161), Cyclin B1 (total) and pCyclin B1(Ser126) in vulvar squamous cell carcinoma and their relations with clinicopatological features and prognosis. [PDF]
PLoS ONE, 2015 Cyclin B1-CDK1 complex plays an important role in the regulation of cell cycle. Activation of Cyclin B1 and CDK1 and the formation of the complex in G2/M are under multiple regulations involving many regulators such as isoforms of 14-3-3 and CDC25 and ...
Zhihui Wang +5 more
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Protein Expression of Cyclin B1, Transferrin Receptor, and Fibronectin Is Correlated with the Prognosis of Adrenal Cortical Carcinoma [PDF]
Endocrinology and Metabolism, 2020 BackgroundAdrenal cortical carcinoma (ACC) is a rare cancer with a variable prognosis. Several prognostic factors of ACC have been previously reported, but a proteomic analysis has not yet been performed.
Sun Joon Moon +3 more
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Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction [PDF]
The EMBO Journal, 2000 The key regulator of G(2)-M transition of the cell cycle is M-phase promoting factor (MPF), a complex composed of cdc2 and a B-type cyclin. Cyclin B1 nuclear localization involves phosphorylation within a region called the cytoplasmic retention signal, which also contains a nuclear export signal.
Kong, Monica +3 more
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