Results 11 to 20 of about 67,241 (220)

Cell cycle-related cyclin b1 quantification. [PDF]

PLoS ONE, 2009
To obtain non-relative measures of cell proteins, purified preparations of the same proteins are used as standards in Western blots. We have previously quantified SV40 large T antigen expressed over a several fold range in different cell lines and ...
Phyllis S Frisa, James W Jacobberger
doaj   +4 more sources

MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C [PDF]

Biology Open, 2015
When cells enter mitosis, the anaphase-promoting complex/cyclosome (APC/C) is activated by phosphorylation and binding of Cdc20. The RXXL destruction box (D-box) of cyclin B1 only binds Cdc20 after release of the spindle checkpoint in metaphase ...
Erik Voets, Rob Wolthuis
doaj   +5 more sources

Spatial control of the APC/C ensures the rapid degradation of cyclin B1. [PDF]

EMBO J
Cirillo L, Young R, Veerapathiran S, Roberti A, Martin M, Abubacar A, Perosa C, Coates C, Muhammad R, Roumeliotis TI, Choudhary JS, Alfieri C, Pines J.   +12 more
europepmc   +2 more sources

CDK5-cyclin B1 regulates mitotic fidelity. [PDF]

Nature
CDK1 has been known to be the sole cyclin-dependent kinase (CDK) partner of cyclin B1 to drive mitotic progression1. Here we demonstrate that CDK5 is active during mitosis and is necessary for maintaining mitotic fidelity. CDK5 is an atypical CDK owing to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p392 ...
Zheng XF, Sarkar A, Lotana H, Syed A, Nguyen H, Ivey RG, Kennedy JJ, Whiteaker JR, Tomasik B, Huang K, Li F, D'Andrea AD, Paulovich AG, Shah K, Spektor A, Chowdhury D.   +15 more
europepmc   +3 more sources

Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression. [PDF]

PLoS Biology, 2007
Activation of cyclin B1-cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key event that initiates mitotic entry.
Arne Lindqvist, Wouter van Zon, Christina Karlsson Rosenthal, Rob M F Wolthuis   +3 more
doaj   +1 more source

Spindle checkpoint: trapped by the corona, cyclin B1 goes MAD. [PDF]

EMBO J, 2020
Conde C, Gassmann R.
europepmc   +3 more sources

Cyclin b1 suppresses colorectal cancer invasion and metastasis by regulating e-cadherin. [PDF]

PLoS ONE, 2015
Cyclin B1, a mitotic cyclin, has been implicated in malignances. However, its contribution to colorectal cancer invasion and metastasis are still not well understood.
Yifeng Fang, Xiao Liang, Wenbin Jiang, Jianbo Li, Junfen Xu, Xiujun Cai   +5 more
doaj   +1 more source

Immunohistochemical Expression of Cyclin B1 in Epithelial Hyperplasia, Dysplasia and Oral Squamous Cell Carcinomas - A Comparative Study [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Cyclin B1 is important in the cell cycle progression from G2 to M phase. Cyclin B1 binds to CDC2, which then becomes dephosphorylated and gets relocated to the nucleus, ensuring the transition toward mitosis.
Kochli Channappa Niranjan, Amsavardani Tayaar, G.S. Kumar, Rekha Krishnapillai, Kaveri Hallikeri, Santosh Hunasgi   +5 more
doaj   +1 more source

Expression of CDK1(Tyr15), pCDK1(Thr161), Cyclin B1 (total) and pCyclin B1(Ser126) in vulvar squamous cell carcinoma and their relations with clinicopatological features and prognosis. [PDF]

PLoS ONE, 2015
Cyclin B1-CDK1 complex plays an important role in the regulation of cell cycle. Activation of Cyclin B1 and CDK1 and the formation of the complex in G2/M are under multiple regulations involving many regulators such as isoforms of 14-3-3 and CDC25 and ...
Zhihui Wang, Ana Slipicevic, Mette Førsund, Claes G Trope, Jahn M Nesland, Ruth Holm   +5 more
doaj   +1 more source

Copper is essential for cyclin B1-mediated CDK1 activation. [PDF]

Nat Commun
Cyclin-dependent kinase 1 (CDK1) is the pivotal kinase responsible for initiating cell division. Its activation is dependent on binding to regulatory cyclins, such as CCNB1. Our research demonstrates that copper binding to both CDK1 and CCNB1 is essential for activating CDK1 in cells.
Wang J, Yang D, Yu HF, Jin J, Nie Y, Zhang S, Ren W, Ge Z, Zhang Z, Ma X, Dai S, Sui G, Teng CB.   +12 more
europepmc   +4 more sources