Results 31 to 40 of about 34,398 (227)
Reproductive Biology and Endocrinology, 2009 Background Progesterone plays an important role in the proliferation and differentiation of human endometrial cells (hECs). Large-dose treatment with progesterone has been used for treatment of endometrial proliferative disorders. However, the mechanisms
Leung Peter CK +8 more
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Transcription factor STOX1A promotes mitotic entry by binding to the CCNB1 promotor. [PDF]
PLoS ONE, 2012 BACKGROUND: In this study we investigated the involvement of the transcription factor STOX1A in the regulation of the cell cycle. METHODOLOGY/PRINCIPAL FINDINGS: We found that several major cell cycle regulatory genes were differentially expressed upon ...
Daan van Abel +3 more
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Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]
PLoS ONE, 2010 The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Danupon Nantajit +5 more
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Viruses, 2016 The human cytomegalovirus (HCMV)-encoded cyclin-dependent kinase (CDK) ortholog pUL97 associates with human cyclin B1 and other types of cyclins. Here, the question was addressed whether cyclin interaction of pUL97 and additional viral proteins is ...
Mirjam Steingruber +9 more
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HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation [PDF]
The EMBO Journal, 2000 Colorectal carcinoma RKO cells expressing reduced levels of the RNA-binding protein HuR (ASHuR) displayed markedly reduced growth. In synchronous RKO populations, HuR was almost exclusively nuclear during early G(1), increasing in the cytoplasm during late G(1), S and G(2).
W, Wang +4 more
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Immunity against Cyclin B1 Tumor Antigen Delays Development of Spontaneous Cyclin B1‐Positive Tumors in p53−/− Mice [PDF]
Annals of the New York Academy of Sciences, 2009 We previously identified cyclin B1‐specific T cells and antibodies in cancer patients with cyclin B1‐positive (+) tumors and also in some healthy individuals. We also demonstrated that these responses may be important in cancer immunosurveillance by showing that vaccination against cyclin B1 prevents growth of transplantable cyclin B1+ tumors in mice ...
Laura A, Vella +3 more
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Cancer Cell International, 2006 Background We have demonstrated that in some human cancer cells both chronic mild heat and ionizing radiation exposures induce a transient block in S and G2 phases of the cell cycle. During this delay, cyclin B1 protein accumulates to supranormal levels,
Phillips Stacia L +4 more
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Effect of demecolcine-assisted enucleation on the MPF level and cyclin B1 distribution in porcine oocytes. [PDF]
PLoS ONE, 2014 Demecolcine (DEM) treatment of oocytes induces formation of a membrane protrusion containing a mass of condensed maternal chromosomes, which can be removed with minimal damage prior to somatic cell nuclear transfer (SCNT).
Suo Li +10 more
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Cell Reports, 2014 The chromosome passenger complex (CPC) must relocate from anaphase chromosomes to the cell equator for successful cytokinesis. Although this landmark event requires the mitotic kinesin MKlp2, the spatiotemporal mechanistic basis remains elusive. Here, we
Mayumi Kitagawa +5 more
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Cyclin A2 Regulates Nuclear-Envelope Breakdown and the Nuclear Accumulation of Cyclin B1 [PDF]
Current Biology, 2007 Mitosis is thought to be triggered by the activation of Cdk-cyclin complexes. Here we have used RNA interference (RNAi) to assess the roles of three mitotic cyclins, cyclins A2, B1, and B2, in the regulation of centrosome separation and nuclear-envelope breakdown (NEB) in HeLa cells.
Gong, Delquin +7 more
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