Results 31 to 40 of about 67,241 (220)
Effect of cyclins and Cdks on the cyclin B1 promoter activation [PDF]
IUBMB Life, 1997 AbstractTo study the effect of several cyclins on cyclin B1 promoter activation, we co‐transfected cyclin A, cyclin E and cyclin D1 expressing plasmids with a cyclin B1 promoter construction driving a luciferase repotnter gene into NIH 3T3 cells. All three cyclins produced activation of the reporter gene, however, co‐transfection of cyclin A with a ...
A, Moro +3 more
openaire +2 more sources
Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol
BMC Cancer, 2008 Background Cyclin B1, the regulatory subunit of cyclin-dependent kinase 1 (Cdk1), is essential for the transition from G2 phase to mitosis. Cyclin B1 is very often found to be overexpressed in primary breast and cervical cancer cells as well as in cancer
Strebhardt Klaus +7 more
doaj +1 more source
Over‐expression of FoxM1 stimulates cyclin B1 expression [PDF]
FEBS Letters, 2001 FoxM1 (previously named WIN, HFH‐11 or Trident) is a Forkhead box (Fox) transcription factor widely expressed in proliferating cells. Various findings, including a recent analysis of FoxM1 knockout mice, suggest that FoxM1 is required for normal S–M coupling during cell cycle progression.
Tsang, ACC +8 more
openaire +4 more sources
Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I [PDF]
Journal of Cell Biology, 2018 Mammalian oocytes are arrested at the prophase of the first meiotic division for months and even years, depending on species. Meiotic resumption of fully grown oocytes requires activation of M-phase–promoting factor (MPF), which is composed of Cyclin B1 and cyclin-dependent kinase 1 (CDK1).
Jian Li +15 more
openaire +3 more sources
Anti-Bladder-Tumor Effect of Baicalein from Scutellaria baicalensis Georgi and Its Application In Vivo [PDF]
, 2013 Some phytochemicals with the characteristics of cytotoxicity and/or antimetastasis have generated intense interest among the anticancer studies. In this study, a natural flavonoid baicalein was evaluated in bladder cancer in vitro and in vivo.
Jiann-Der Wu +7 more
core +1 more source
Immune Response to Cyclin B1 in Hepatocellular Carcinoma [PDF]
Hepatology, 1997 Proteins expressed by plasmids encoding human cyclins and cyclin–dependent kinase 2 (CDK2) were used as antigens in immunoblotting. Fifteen of 100 patients with hepatocellular carcinoma (HCC) were found to have autoantibodies reactive with cyclin B1 and with a 40–kd degradation product of ...
G, Covini +5 more
openaire +3 more sources
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding [PDF]
, 2003 The order and fidelity of cell cycle events in mammals is intimately linked to the integrity of the Chk1 kinase-Cdc25A phosphatase pathway. Chk1 phosphorylation targets Cdc25A for destruction and, as shown here, inhibits interactions between Cdc25A and ...
Chen, Mei-Shya +2 more
core +3 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CCNB1 (cyclin B1), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +2 more sources
Reproductive Biology and Endocrinology, 2009 Background Progesterone plays an important role in the proliferation and differentiation of human endometrial cells (hECs). Large-dose treatment with progesterone has been used for treatment of endometrial proliferative disorders. However, the mechanisms
Leung Peter CK +8 more
doaj +1 more source
Transcription factor STOX1A promotes mitotic entry by binding to the CCNB1 promotor. [PDF]
PLoS ONE, 2012 BACKGROUND: In this study we investigated the involvement of the transcription factor STOX1A in the regulation of the cell cycle. METHODOLOGY/PRINCIPAL FINDINGS: We found that several major cell cycle regulatory genes were differentially expressed upon ...
Daan van Abel +3 more
doaj +1 more source