The kinetics of G2 and M transitions regulated by B cyclins. [PDF]
PLoS ONE, 2013 B cyclins regulate G2-M transition. Because human somatic cells continue to cycle after reduction of cyclin B1 (cycB1) or cyclin B2 (cycB2) by RNA interference (RNAi), and because cycB2 knockout mice are viable, the existence of two genes should be an ...
Yehong Huang +2 more
doaj +1 more source
Biology, 2022 Cyclin-like genes are primarily considered as cell cycle regulators and have shown to be crucial for insect growth, development, reproduction, and fertility.
Muhammad Asad +5 more
doaj +1 more source
Cyclin B1 and Other Cyclins as Tumor Antigens in Immunosurveillance and Immunotherapy of Cancer [PDF]
Cancer Research, 2006 Abstract Uncontrolled cell division is an indispensable event in tumor progression, and numerous molecules involved in this process have been the focus of intense investigation in tumor biology. Cyclins, molecules that orchestrate normal cell cycle progression, are abnormally overexpressed in various human cancers.
Laura A. Vella +2 more
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TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
STOX1 Isoform A Promotes Proliferation and Progression of Hepatocellular Carcinoma by Dual Mechanisms of Transcriptionally Upregulation of Cyclin B1 and Activation of ROS-Dependent PTEN/AKT1 Signaling. [PDF]
Cancer MedABSTRACT Background Dysregulation of transcription factors is one of the most common factors for the pathogenesis of hepatocellular carcinoma (HCC). To the best of our knowledge, no study has yet investigated the clinical significance and functional role of STOX1 in HCC. Methods Real‐time PCR, Western blotting and immunohistochemistry were performed to
Jiang C +17 more
europepmc +2 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CCNB1 (cyclin B1), with data on DNA, on the protein encoded, and where the gene is implicated.
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Meiotic Maturation of the Mouse Oocyte Requires an Equilibrium between Cyclin B Synthesis and Degradation [PDF]
, 2001 Among the proteins whose synthesis and/or degradation is necessary for a proper progression through meiotic maturation, cyclin B appears to be one of the most important.
Ledan, Emilie +3 more
core +1 more source
Immune Response to Cyclin B1 in Hepatocellular Carcinoma [PDF]
Hepatology, 1997 Proteins expressed by plasmids encoding human cyclins and cyclin–dependent kinase 2 (CDK2) were used as antigens in immunoblotting. Fifteen of 100 patients with hepatocellular carcinoma (HCC) were found to have autoantibodies reactive with cyclin B1 and with a 40–kd degradation product of ...
Syed Ahmed Morshed +5 more
openaire +2 more sources
Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma-A correlation with clinicopathological features [PDF]
, 2013 Background: Nuclear localization of cyclin B1 is an indicator for cells undergoing mitotic division, and the overexpression has shown promising results as a good prognostic predictor for patients of squamous cell carcinoma (SCC). Cyclin B1 overexpression
Balappanavar, Aswini Y. +5 more
core +1 more source
Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes [PDF]
, 2003 Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities.
Datwyler, D. A. +5 more
core +1 more source