Cyclin A2 Regulates Nuclear-Envelope Breakdown and the Nuclear Accumulation of Cyclin B1 [PDF]
Current Biology, 2007 Mitosis is thought to be triggered by the activation of Cdk-cyclin complexes. Here we have used RNA interference (RNAi) to assess the roles of three mitotic cyclins, cyclins A2, B1, and B2, in the regulation of centrosome separation and nuclear-envelope breakdown (NEB) in HeLa cells.
Jason W. Myers +7 more
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An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination [PDF]
, 2012 The Anaphase-Promoting Complex/Cyclosome (APC) is a ubiquitin ligase required for exit from mitosis. We previously showed that Tosyl Arginine Methyl Ester (TAME) inhibits APC-dependent proteolysis by competing with the C-terminal IR-tail of the APC ...
King, Randall Wharton, Zeng, Xing
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Upregulation of Cyclin B1 by miRNA and its implications in cancer [PDF]
Nucleic Acids Research, 2011 It is largely recognized that microRNAs (miRNAs) function to silence gene expression by targeting 3'UTR regions. However, miRNAs have also been implicated to positively-regulate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa).
Huang, Vera +9 more
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Translational Control of Cyclin B1 mRNA during Meiotic Maturation: Coordinated Repression and Cytoplasmic Polyadenylation [PDF]
, 2000 Translational control is prominent during meiotic maturation and early development. In this report, we investigate a mode of translational repression in Xenopus laevis oocytes, focusing on the mRNA encoding cyclin B1.
Barkoff, Aaron F. +3 more
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Reproductive Biology and Endocrinology, 2009 Background Progesterone plays an important role in the proliferation and differentiation of human endometrial cells (hECs). Large-dose treatment with progesterone has been used for treatment of endometrial proliferative disorders. However, the mechanisms
Leung Peter CK +8 more
doaj +1 more source
Transcription factor STOX1A promotes mitotic entry by binding to the CCNB1 promotor. [PDF]
PLoS ONE, 2012 BACKGROUND: In this study we investigated the involvement of the transcription factor STOX1A in the regulation of the cell cycle. METHODOLOGY/PRINCIPAL FINDINGS: We found that several major cell cycle regulatory genes were differentially expressed upon ...
Daan van Abel +3 more
doaj +1 more source
Anti-Bladder-Tumor Effect of Baicalein from Scutellaria baicalensis Georgi and Its Application In Vivo [PDF]
, 2013 Some phytochemicals with the characteristics of cytotoxicity and/or antimetastasis have generated intense interest among the anticancer studies. In this study, a natural flavonoid baicalein was evaluated in bladder cancer in vitro and in vivo.
Jiann-Der Wu +7 more
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Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol [PDF]
, 2012 Earlier studies showed that 2-methoxyestradiol (2ME2), an endogenous nonpolar metabolite of estradiol-17β, is a strong inducer of G2/M cell cycle arrest (based on analysis of cellular DNA content) in human cancer cell lines.
Choi, Hye Joung, Zhu, Bao Ting
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Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding [PDF]
, 2003 The order and fidelity of cell cycle events in mammals is intimately linked to the integrity of the Chk1 kinase-Cdc25A phosphatase pathway. Chk1 phosphorylation targets Cdc25A for destruction and, as shown here, inhibits interactions between Cdc25A and ...
Chen, Mei-Shya +2 more
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Immunity against Cyclin B1 Tumor Antigen Delays Development of Spontaneous Cyclin B1‐Positive Tumors in p53−/− Mice [PDF]
Annals of the New York Academy of Sciences, 2009 We previously identified cyclin B1‐specific T cells and antibodies in cancer patients with cyclin B1‐positive (+) tumors and also in some healthy individuals. We also demonstrated that these responses may be important in cancer immunosurveillance by showing that vaccination against cyclin B1 prevents growth of transplantable cyclin B1+ tumors in mice ...
Olivera J. Finn +3 more
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