Results 51 to 60 of about 63,908 (269)
Viruses, 2016 The human cytomegalovirus (HCMV)-encoded cyclin-dependent kinase (CDK) ortholog pUL97 associates with human cyclin B1 and other types of cyclins. Here, the question was addressed whether cyclin interaction of pUL97 and additional viral proteins is ...
Mirjam Steingruber +9 more
doaj +1 more source
Reversal of terminal differentiation and control of DNA replication [PDF]
, 1993 DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that terminally differentiated myotubes can be induced to reenter S phase and show the same pattern of replication foci as cycling cells.
Cardoso, M. Cristina +2 more
core +1 more source
Orchestration of the spindle assembly checkpoint by CDK1‐cyclin B1 [PDF]
FEBS Letters, 2019 In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐kinetochore attachments during capture of chromosomes by the mitotic spindle. Spindle assembly is complete once there are no longer any unattached kinetochores. Here, we will discuss the mechanism and key components of spindle checkpoint signalling.
Hayward, D +2 more
openaire +4 more sources
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation [PDF]
, 1993 In normal human diploid fibroblasts, cyclins of the A, B, and D classes each associate with cyclin-dependent kinases (CDKs), proliferating cell nuclear antigen (PCNA), and p21, thereby forming multiple independent quaternary complexes.
Beach, D., Xiong, Y., Zhang, H.
core +1 more source
Aneuploidy in oocytes is prevented by sustained CDK1 activity through degron masking in cyclin B1 [PDF]
, 2019 Successful mitosis requires that cyclin B1:CDK1 kinase activity remains high until chromosomes are correctly aligned on the mitotic spindle. It has therefore been unclear why, in mammalian oocyte meiosis, cyclin B1 destruction begins before chromosome ...
Davies, Owen R. +4 more
core +1 more source
Cell Reports, 2014 The chromosome passenger complex (CPC) must relocate from anaphase chromosomes to the cell equator for successful cytokinesis. Although this landmark event requires the mitotic kinesin MKlp2, the spatiotemporal mechanistic basis remains elusive. Here, we
Mayumi Kitagawa +5 more
doaj +1 more source
Effect of demecolcine-assisted enucleation on the MPF level and cyclin B1 distribution in porcine oocytes. [PDF]
PLoS ONE, 2014 Demecolcine (DEM) treatment of oocytes induces formation of a membrane protrusion containing a mass of condensed maternal chromosomes, which can be removed with minimal damage prior to somatic cell nuclear transfer (SCNT).
Suo Li +10 more
doaj +1 more source
HPV16 E1^E4 protein is phosphorylated by Cdk2/cyclin A and relocalizes this complex to the cytoplasm [PDF]
, 2006 The human papillomavirus type 16 E1^E4 protein is expressed abundantly in cells supporting viral DNA amplification, but its expression is lost during malignant progression.
Ayub, Mahmood +5 more
core +1 more source
BMC Research Notes, 2009 Background The cell cycle is promoted by activation of cyclin dependent kinases (Cdks), which are regulated positively by cyclins and negatively by Cdk inhibitors. Proliferation of carcinoma is associated with altered regulation of the cell cycle. Little
Collan Yrjö +6 more
doaj +1 more source
Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis. [PDF]
, 2018 There is remarkable redundancy between the Cyclin-Cdk complexes that comprise the cell cycle machinery. None of the mammalian A-, D-, or E-type cyclins are required in development until implantation, and only Cdk1 is essential for early cell divisions ...
Andrew Harrison +57 more
core +3 more sources