Results 61 to 70 of about 63,908 (269)

MnSOD and Cyclin B1 Coordinate a Mito-Checkpoint during Cell Cycle Response to Oxidative Stress

Antioxidants, 2017
Communication between the nucleus and mitochondrion could coordinate many cellular processes. While the mechanisms regulating this communication are not completely understood, we hypothesize that cell cycle checkpoint proteins coordinate the cross-talk ...
Amanda L. Kalen, Iman M. Ahmad, Maher Y. Abdalla, Yunxia Q. O’Malley, Prabhat C. Goswami, Ehab H. Sarsour   +5 more
doaj   +1 more source

The Impact of Cyclin B1 on Tuberin Stabilization [PDF]

, 2022
Tuberous Sclerosis Complex (TSC) is an autosomal dominant disorder caused by various mutations in either TSC1 or TSC2, genes that encode the proteins Hamartin and Tuberin respectively.
Fidalgo da Silva, Elizabeth, Fong, Jackie, Mitrevski, Aiden, Porter, Lisa   +3 more
core   +1 more source

Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase [PDF]

, 2014
Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1].
Amalie E. Dick, Andrew D. McAinsh, Christopher A. Smith, Clute, Collin, Daniel W. Gerlich, Daum, Dick, D’Angiolella, Gavet, Hagting, He, Higuchi, Hümmer, Joglekar, Kabeche, Lara-Gonzalez, Laurent Sansregret, Mark Petronczki, María Dolores Vázquez-Novelle, Mirchenko, Morin, Nasmyth, Nezi, Oliveira, Palframan, Parry, Peters, Rattani, Santaguida, Stemmann, Stevens, Vázquez-Novelle, Vázquez-Novelle, Wolf, Yamaguchi, Zhai   +36 more
core   +1 more source

HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation [PDF]

The EMBO Journal, 2000
Colorectal carcinoma RKO cells expressing reduced levels of the RNA-binding protein HuR (ASHuR) displayed markedly reduced growth. In synchronous RKO populations, HuR was almost exclusively nuclear during early G(1), increasing in the cytoplasm during late G(1), S and G(2).
M.Craig Caldwell, Shankung Lin, Wengong Wang, Henry Furneaux, Myriam Gorospe   +4 more
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Preferential Autoimmune Response in Prostate Cancer to Cyclin B1 in a Panel of Tumor-Associated Antigens

Journal of Immunology Research, 2014
Previous studies have demonstrated that sera from patients with prostate cancer (PCa) contain autoantibodies that react with tumor-associated antigens (TAAs).
Liping Dai, Jitian Li, Rosalia Ortega, Wei Qian, Carlos A. Casiano, Jian-Ying Zhang   +5 more
doaj   +1 more source

Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance. [PDF]

, 2019
A mammalian cell houses two genomes located separately in the nucleus and mitochondria. During evolution, communications and adaptations between these two genomes occur extensively to achieve and sustain homeostasis for cellular functions and ...
Jiang, Nian, Li, Jian Jian, Wang, Shuangyan, Xie, Bowen   +3 more
core  

Analyses of zebrafish and Xenopus oocyte maturation reveal conserved and diverged features of translational regulation of maternal cyclin B1 mRNA [PDF]

, 2009
Background Vertebrate development relies on the regulated translation of stored maternal mRNAs, but how these regulatory mechanisms may have evolved to control translational efficiency of individual mRNAs is poorly understood.
A Charlesworth, A Charlesworth, AF Barkoff, B Stebbins-Boaz, BR Fritz, C Tribulo, CA Fox, CA Fox, CH de Moor, CK Prasad, DC Barnard, DF Colgan, DR Gallie, F Pelegri, J Lyman Gingerich, J Tay, L Bally-Cuif, L Vardy, LE Hake, LE Hake, LJ Colegrove-Otero, LL McGrew, M Pique, MD Sheets, Michael D Sheets, R Dosch, R Mendez, R Mendez, S Danckwardt, S Kuersten, S Nakahata, S Nakahata, S Vasudevan, SA Connors, T Kondo, T Kondo, T Yabe, Yan Zhang   +37 more
core   +3 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Ampelopsin induces MDA-MB-231 cell cycle arrest through cyclin B1-mediated PI3K/AKT/mTOR pathway in vitro and in vivo

Acta Pharmaceutica, 2023
Breast cancer is one of the most common malignant tumors in women and it is the most frequently diagnosed cancer in the world. Ampelopsin (AMP) is a purified component from the root of Ampelopsis grossedentata. It is reported that AMP could significantly
Meng Minjun, Yang Qiaolu, Ouyang Zhong, Yang Qingmo, Wu Xinyi, Huang Yufan, Su Yonghui, Chen Shuanglong, Chen Wenlin   +8 more
doaj   +1 more source