Results 81 to 90 of about 67,241 (220)
Growth dynamics and cyclin expression in cutaneous T-cell lymphoma cell lines
Dermatology Reports, 2010 We have investigated cell growth dynamics and cyclins B1 and E expression in cell lines derived from mycosis fungoides (MyLa), Sézary syndrome (SeAx), and CD30+ lympho-proliferative diseases (Mac1, Mac2a, JK).
Edyta Biskup +3 more
doaj +1 more source
Investigations into the molecular effects of single nucleotide polymorphism [PDF]
, 2000 Objectives: DNA sequences are very rich in short repeats and their pattern can be altered by point mutations. We wanted to investigate the effect of single nucleotide polymorphism (SNP) on the pattern of short DNA repeats and its biological consequences.
Lohrer, Horst D., Tangen, Uwe
core +1 more source
p53 regulates a G 2 checkpoint through cyclin B1 [PDF]
Proceedings of the National Academy of Sciences, 1999 The p53 tumor suppressor controls multiple cell cycle checkpoints regulating the mammalian response to DNA damage. To identify the mechanism by which p53 regulates G 2 , we have derived a human ovarian cell that undergoes p53-dependent G 2 arrest at 32°C. We have found that p53 prevents G
S A, Innocente +3 more
openaire +2 more sources
Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma
Annals of Agricultural and Environmental Medicine, 2015 [b]Introduction and objectives. [/b]Cyclin A, encoded by CCNA (cyclin A) gene with locus in chromosome 4q27, and cyclin B1, encoded by CCNB1 (cyclin B1) gene with locus in chromosome 5q12, are proteins that play a key role in the passage through the ...
Anna Cyniak-Magierska +5 more
doaj +1 more source
LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice [PDF]
, 2015 Mammalian oocytes are arrested at prophase I until puberty when hormonal signals induce the resumption of meiosis I and progression to meiosis II.
Chen, T +8 more
core +1 more source
Cell Proliferation, 1996 Abstract. Neoplastic transformation of mouse mammary epithelial cells is the result of several identifiable phenotypic changes which presumably require sequential genetic alterations. In our model system, mammary cells progress from a mortal state (virgin duct) to several morphologically distinct intermediate states.
T K, Said, S, Bonnette, D, Medina
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Gastroenterology Research and Practice, 2009 Adenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development. A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992–2000 was investigated and was ...
Rolf Aamodt +5 more
doaj +1 more source
The toxic effects and possible mechanisms of Brusatol on mouse oocytes. [PDF]
PLoS ONE, 2017 Brusatol is a natural quassinoid that shows a potential therapeutic use in cancer models by the inhibition of Nuclear factor erythroid 2-related factor 2 (Nrf2) and is capable of inducing a variety of biological effects. The effects of Brusatol on oocyte
Rujun Ma +6 more
doaj +1 more source
Optimization of a genetically encoded biosensor for cyclin B1-cyclin dependent kinase 1
Mol. BioSyst., 2014 Fluorescent protein (FP)-based biosensors have revolutionized the ability of researchers to monitor enzyme activities in live cells. While the basic design principles for FP-based biosensors are well established, first-generation biosensor constructs typically suffer from relatively low fluorescence responses that limit their general applicability. The
Ahmed Saied F, Belal +4 more
openaire +3 more sources
Cell Reports, 2012 In meiosis, two specialized cell divisions allow the separation of paired chromosomes first, then of sister chromatids. Separase removes the cohesin complex holding sister chromatids together in a stepwise manner from chromosome arms in meiosis I, then ...
Sandra A. Touati +10 more
doaj +1 more source