Deciphering the binding behavior of flavonoids to the cyclin dependent kinase 6/cyclin D complex. [PDF]
PLoS ONE, 2018 Flavonoids, a class of natural compounds with variable phenolic structures, have been found to possess anti-cancer activities by modulating different enzymes and receptors like CDK6.
Jingxiao Zhang +4 more
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Cyclin D mediates tolerance of genome-doubling in cancers with functional p53. [PDF]
Ann Oncol, 2017 BACKGROUND: Aneuploidy and chromosomal instability (CIN) are common features of human malignancy that fuel genetic heterogeneity. Although tolerance to tetraploidization, an intermediate state that further exacerbates CIN, is frequently mediated by TP53 ...
Crockford A +13 more
europepmc +6 more sources
PD-L1 Expression Fluctuates Concurrently with Cyclin D in Glioblastoma Cells [PDF]
Cells, 2021 Despite Glioblastoma (GBM) frequently expressing programmed cell death ligand-1 (PD-L1), treatment with anti-programmed cell death-1 (PD1) has not yielded brilliant results. Intratumor variability of PD-L1 can impact determination accuracy.
Martina Tufano +7 more
doaj +2 more sources
Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. [PDF]
, 1993 Mammalian D-type cyclins are growth factor-regulated, delayed early response genes that are presumed to control progression through the G1 phase of the cell cycle by governing the activity of cyclin-dependent kinases (cdks).
Dawn E. Quelle +6 more
openalex +3 more sources
Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy [PDF]
npj Breast Cancer, 2022 Despite the biological and therapeutic relevance of CDK4/6 for the treatment of HR+, HER2- advanced breast cancer, the detailed mode of action of CDK4/6 inhibitors is not completely understood.
Severine Isabelle Gharbi +22 more
doaj +2 more sources
Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix. [PDF]
Mol Cell, 2019 The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by ...
Topacio BR +8 more
europepmc +3 more sources
Targeting the cyclin D/CDK4 Axis to unlock new therapeutic approaches to enhance cancer treatment. [PDF]
PLoS ONEDysregulation of the cyclin D/CDK complex is a common feature in various cancers, including colorectal, breast, and melanoma, leading to uncontrolled tumor growth and cell cycle progression.
Ibrahim Khater, Aaya Nassar
doaj +2 more sources
Cyclin D activates the Rb tumor suppressor by mono-phosphorylation [PDF]
eLife, 2014 The widely accepted model of G1 cell cycle progression proposes that cyclin D:Cdk4/6 inactivates the Rb tumor suppressor during early G1 phase by progressive multi-phosphorylation, termed hypo-phosphorylation, to release E2F transcription factors ...
Anil M Narasimha +5 more
doaj +2 more sources
Sumoylation of cyclin and its therapeutic potential for cancer [PDF]
Animal Cells and SystemsThe precision of the cell cycle is essential for organismal development, tissue homeostasis, and the prevention of malignancies. Cyclins and cyclin-dependent kinases (CDKs) play pivotal roles in regulating cell cycle progression.
Hong-Yeoul Ryu, Mark Hochstrasser
doaj +2 more sources
The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D. [PDF]
Nature, 2021 Chaikovsky AC +29 more
europepmc +3 more sources