PD-L1 Expression Fluctuates Concurrently with Cyclin D in Glioblastoma Cells [PDF]
Cells, 2021 Despite Glioblastoma (GBM) frequently expressing programmed cell death ligand-1 (PD-L1), treatment with anti-programmed cell death-1 (PD1) has not yielded brilliant results. Intratumor variability of PD-L1 can impact determination accuracy.
Martina Tufano +7 more
doaj +2 more sources
HIV-1 expression induces cyclin D1 expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy [PDF]
BMC Microbiology, 2002 Background The aberrant cell-cycle progression of HIV-1-infected kidney cells plays a major role in the pathogenesis of HIV-associated nephropathy, however the mechanisms whereby HIV-1 induces infected glomerular podocytes or infected tubular epithelium ...
Husain Mohammad +3 more
doaj +4 more sources
Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy [PDF]
npj Breast Cancer, 2022 Despite the biological and therapeutic relevance of CDK4/6 for the treatment of HR+, HER2- advanced breast cancer, the detailed mode of action of CDK4/6 inhibitors is not completely understood.
Severine Isabelle Gharbi +22 more
doaj +2 more sources
Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix. [PDF]
Mol Cell, 2019 The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by ...
Topacio BR +8 more
europepmc +3 more sources
Deciphering the binding behavior of flavonoids to the cyclin dependent kinase 6/cyclin D complex. [PDF]
PLoS ONE, 2018 Flavonoids, a class of natural compounds with variable phenolic structures, have been found to possess anti-cancer activities by modulating different enzymes and receptors like CDK6.
Jingxiao Zhang +4 more
doaj +2 more sources
Cyclin D activates the Rb tumor suppressor by mono-phosphorylation [PDF]
eLife, 2014 The widely accepted model of G1 cell cycle progression proposes that cyclin D:Cdk4/6 inactivates the Rb tumor suppressor during early G1 phase by progressive multi-phosphorylation, termed hypo-phosphorylation, to release E2F transcription factors ...
Anil M Narasimha +5 more
doaj +2 more sources
Bifurcation in cell cycle dynamics regulated by p53 [PDF]
arXiv, 2014 We study the regulating mechanism of p53 on the properties of cell cycle dynamics in the light of the proposed model of interacting p53 and cell cycle networks via p53. Irradiation (IR) introduce to p53 compel p53 dynamics to suffer different phases, namely oscillating and oscillation death (stabilized) phases.
Alam, Md. Jahoor +3 more
arxiv +4 more sources
F-box protein FBXO32 ubiquitinates and stabilizes D-type cyclins to drive cancer progression [PDF]
Nature CommunicationsD-type cyclins (hereafter, cyclin D) are central regulators orchestrating G1/S cell cycle transition. Accordingly, aberrant expression of cyclin D is strongly correlated with proliferation-related diseases such as cancer.
Feng Li +15 more
doaj +2 more sources
Cyclin D mediates tolerance of genome-doubling in cancers with functional p53. [PDF]
Ann Oncol, 2017 BACKGROUND: Aneuploidy and chromosomal instability (CIN) are common features of human malignancy that fuel genetic heterogeneity. Although tolerance to tetraploidization, an intermediate state that further exacerbates CIN, is frequently mediated by TP53 ...
Crockford A +13 more
europepmc +3 more sources
Alleviation of cisplatin-induced hepatotoxicity and nephrotoxicity by L-carnitine [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): To assess the protective effect of L-carnitine in reducing cisplatin toxicity via estimating biochemical tests, histomorphometric, and immunohistochemistry (IHC) of β-catenin and cyclin D.Materials and Methods: Fifteen adult male rabbits ...
snur Hassan +3 more
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