Deciphering the binding behavior of flavonoids to the cyclin dependent kinase 6/cyclin D complex. [PDF]
PLoS ONE, 2018 Flavonoids, a class of natural compounds with variable phenolic structures, have been found to possess anti-cancer activities by modulating different enzymes and receptors like CDK6.
Jingxiao Zhang +4 more
doaj +6 more sources
PD-L1 Expression Fluctuates Concurrently with Cyclin D in Glioblastoma Cells [PDF]
Cells, 2021 Despite Glioblastoma (GBM) frequently expressing programmed cell death ligand-1 (PD-L1), treatment with anti-programmed cell death-1 (PD1) has not yielded brilliant results. Intratumor variability of PD-L1 can impact determination accuracy.
Martina Tufano +7 more
doaj +3 more sources
The regulation of cyclin D promoters – review
Cancer Treatment and Research Communications, 2021 Cyclins are key regulators of cell cycle progression and survival. Particularly cyclins D (cyclin D1, D2, and D3) act in response to the mitogenic stimulation and are pivotal mediators between proliferative pathways and the nuclear cell cycle machinery ...
Jan Pawlonka +2 more
doaj +4 more sources
Cyclin D activates the Rb tumor suppressor by mono-phosphorylation [PDF]
eLife, 2014 The widely accepted model of G1 cell cycle progression proposes that cyclin D:Cdk4/6 inactivates the Rb tumor suppressor during early G1 phase by progressive multi-phosphorylation, termed hypo-phosphorylation, to release E2F transcription factors ...
Anil M Narasimha +5 more
doaj +3 more sources
The requirement for cyclin D function in tumor maintenance. [PDF]
Cancer Cell, 2012 D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains that allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D-associated kinase activity in mice bearing ErbB2-driven mammary ...
Choi YJ +10 more
europepmc +6 more sources
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2. [PDF]
Nat Commun, 2021 Since their discovery as drivers of proliferation, cyclin-dependent kinases (CDKs) have been considered therapeutic targets. Small molecule inhibitors of CDK4/6 are used and tested in clinical trials to treat multiple cancer types. Despite their clinical
Pack LR, Daigh LH, Chung M, Meyer T.
europepmc +2 more sources
LncRNA CDKN2B-AS1/miR-141/cyclin D network regulates tumor progression and metastasis of renal cell carcinoma. [PDF]
Cell Death Dis, 2020 The molecular heterogeneity of renal cell carcinoma (RCC) complicates the therapeutic interventions for advanced metastatic disease and thus its management remains a significant challenge. This study investigates the role of the lncRNA CDKN2B-AS1 and miR-
Dasgupta P +11 more
europepmc +2 more sources
Cyclin D and cyclin E expression in normal and adenomatous pituitary [PDF]
European Journal of Endocrinology, 2000 OBJECTIVES: Cyclins play an important role in the regulation of cell progression through the cell cycle. Over-expression of the cyclins has been shown in many different tumour types. Pituitary adenomas are a common form of endocrine neoplasia in the human, but have been little studied in terms of the expression of the principal cyclins regulating ...
Suzanne Jordan +4 more
openalex +3 more sources
Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy [PDF]
npj Breast Cancer, 2022 Despite the biological and therapeutic relevance of CDK4/6 for the treatment of HR+, HER2- advanced breast cancer, the detailed mode of action of CDK4/6 inhibitors is not completely understood.
Severine Isabelle Gharbi +22 more
doaj +2 more sources
Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins. [PDF]
Bioinformation, 2020 Piperine is a component of Piper nigrum (Black pepper). It is well known in ayurvedic formulations. Piperine is a bioenhancer as it reduces the activity of drug-metabolizing enzymes in rodents and thereby enhancing the plasma concentrations of several drugs, including the Pglycoprotein substrates.
Rekha UV +9 more
europepmc +4 more sources