Results 1 to 10 of about 473,167 (167)
Cyclin D and cyclin E expression in normal and adenomatous pituitary [PDF]
European Journal of Endocrinology, 2000 OBJECTIVES: Cyclins play an important role in the regulation of cell progression through the cell cycle. Over-expression of the cyclins has been shown in many different tumour types. Pituitary adenomas are a common form of endocrine neoplasia in the human, but have been little studied in terms of the expression of the principal cyclins regulating ...
Suzanne Jordan +4 more
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Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins. [PDF]
Bioinformation, 2020 Piperine is a component of Piper nigrum (Black pepper). It is well known in ayurvedic formulations. Piperine is a bioenhancer as it reduces the activity of drug-metabolizing enzymes in rodents and thereby enhancing the plasma concentrations of several drugs, including the Pglycoprotein substrates.
Rekha UV +9 more
europepmc +4 more sources
Cyclin D in Left Ventricle Hypertrophy [PDF]
Cell Cycle, 2003 Left ventricle hypertrophy is induced by a number of stimuli and can lead to cardio-myopathy and heart failure. The hypertrophic response is achieved by enlargement of the cardiac myocytes and is regulated by multiple signaling pathways, with the D-type cyclins playing a crucial role.
Peter Kamp Busk, Rebecca Hinrichsen
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Arabidopsis D-Type Cyclin CYCD4;1 Is a Novel Cyclin Partner of B2-Type Cyclin-Dependent Kinase [PDF]
Plant Physiology, 2003 Abstract B-type cyclin-dependent kinases (CDKs) are unique to plants and are assumed to be involved in the control of the G2-to-M phase progression and mitotic events. However, little is known about their cyclin partners. In Arabidopsis, we isolated cDNA encoding the D-type cyclin CYCD4;1 by a yeast (Saccharomyces cerevisiae) two-hybrid ...
Atsushi Kono +5 more
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The requirement for cyclin D function in tumor maintenance. [PDF]
Cancer Cell, 2012 D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains that allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D-associated kinase activity in mice bearing ErbB2-driven mammary ...
Choi YJ +10 more
europepmc +5 more sources
Deciphering the binding behavior of flavonoids to the cyclin dependent kinase 6/cyclin D complex. [PDF]
PLoS One, 2018 Flavonoids, a class of natural compounds with variable phenolic structures, have been found to possess anti-cancer activities by modulating different enzymes and receptors like CDK6. To understand the binding behavior of flavonoids that inhibit the active CDK6, molecular dynamics (MD) simulations were performed on six inhibitors, chrysin (M01), fisetin
Zhang J, Zhang L, Xu Y, Jiang S, Shao Y.
europepmc +5 more sources
Plant D–type cyclins and the control of G1 progression [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2002 The basic pattern of controls that operate during the G1 phase of the plant cell cycle shows much closer similarity to animals than to the yeasts and other fungi. The activity of D–type cyclin (CycD) kinases is induced in response to stimulatory signals, and these phosphorylate the plant homologue of the retinoblastoma tumour susceptibility (Rb ...
E. Ann Oakenfull +2 more
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Cyclin E — a better prognostic marker for breast cancer than cyclin D? [PDF]
Nature Medicine, 1996 Q. Ping Dou +2 more
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D-Type Cyclins in Development and Disease
Genes, 2023 D-type cyclins encode G1/S cell cycle checkpoint proteins, which play a crucial role in defining cell cycle exit and progression. Precise control of cell cycle exit is vital during embryonic development, with defects in the pathways regulating intracellular D-type cyclins resulting in abnormal initiation of stem cell differentiation in a variety of ...
Mostafa Saleban +2 more
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D cyclins in lymphocytes [PDF]
Cytometry Part A, 2004 AbstractBackgroundD cyclins are essential for the progression of cells through the G1 phase of the cell cycle. There are three distinct D cyclins. Cyclin D1 has been shown to be expressed by many different types of cells but not by lymphocytes. Cyclins D2 and D3 have been found in lymphocytes.MethodsWe used high‐resolution enzymatic amplification ...
William Husel +4 more
openaire +3 more sources