The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D. [PDF]
Nature, 2021 Chaikovsky AC +29 more
europepmc +1 more source
Switching cyclin D-Cdk4 kinase activity on and off [PDF]
Cell Cycle, 2008 The cyclin-cdks are master regulators of cell proliferation. These serine/threonine kinases are the motors that both start and stop the cell cycle in response to proliferative or antiproliferative signals. They phosphorylate substrates required to trigger orderly cell cycle progression, and thus their activity is tightly regulated in order to prevent ...
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Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]
, 2010 The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Duru, Nadire +5 more
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Expression of cyclins A and D and p21(waf1/cip1) proteins in renal cell cancer and their relation to clinicopathological variables and patient survival [PDF]
, 1999 S. Aaltomaa +5 more
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Expression of Concern for James et al., "Differential Modification of p27Kip1 Controls Its Cyclin D-cdk4 Inhibitory Activity". [PDF]
Mol Cell Biol, 2022 American Society for Microbiology.
europepmc +1 more source
Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]
, 2018 Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar +16 more
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Regulation of the catalytic subunit (p34PSK-J3/cdk4) for the major D-type cyclin in mature B lymphocytes. [PDF]
, 1996 Debra A. Tanguay, Thomas C. Chiles
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Expression of Concern for Ray et al., "p27Kip1 Inhibits Cyclin D-Cyclin-Dependent Kinase 4 by Two Independent Modes". [PDF]
Mol Cell Biol, 2022 American Society for Microbiology.
europepmc +1 more source
Cyclin D/Cdk4: New Insights from Drosophila [PDF]
Cell Cycle, 2004 The Drosophila cyclin-dependent protein kinase complex CycD/Cdk4 has been known to drive cellular growth (accumulation of mass) as well as proliferation (cell cycle progression). Recent data demonstrate that Hif prolyl hydroxylase (Hph) is required for the induction of growth, but not for the induction of proliferation.
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[原著］Expression of G1 cyclins and cyclin-dependent kinases after transient ischemia in the rat hippocampus [PDF]
, 1996 The mechanisms of delayed neuronal death (DND) have been investigated from several aspects, but they are not fully known. In this study, we examined the expressions of G1 cyclins and cyclin-dependent kinases (cdks) in the rat hippocampus after transient ...
Nakashima, Yasutsugu +2 more
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