The pro-autophagic protein AMBRA1 coordinates cell cycle progression by regulating CCND (cyclin D) stability. [PDF]
Autophagy, 2021 Maiani E, Milletti G, Cecconi F.
europepmc +1 more source
On the automorphism groups of algebraic bounded domains [PDF]
arXiv, 1994 Let $D$ be a bounded domain in $C^n$. By the theorem of H.~Cartan, the group $Aut(D)$ of all biholomorphic automorphisms of $D$ has a unique structure of a real Lie group such that the action $Aut(D)\times D\to D$ is real analytic. This structure is defined by the embedding $C_v\colon Aut(D)\hookrightarrow D\times Gl_n(C)$, $f\mapsto (f(v), f_{*v ...
arxiv
Isolation of Drosophila cyclin D, a protein expressed in the morphogenetic furrow before entry into S phase. [PDF]
, 1996 Russell L. Finley +3 more
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Consequences of Discontinuing a 4/6 Cyclin D-Dependent Kinase Inhibitor During Endocrine Treatment in Hormone-Sensitive Metastatic Breast Cancer Patients in the Context of the COVID-19 Outbreak. [PDF]
Clin Breast Cancer, 2023 Martin S +10 more
europepmc +1 more source
Inactivation of the Cyclin D-dependent Kinase in the Rat Fibroblast Cell Line, 3Y1, Induced by Contact Inhibition [PDF]
, 1997 Akira Kato +3 more
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Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2. [PDF]
Nat Commun, 2021 Pack LR, Daigh LH, Chung M, Meyer T.
europepmc +1 more source
The high expression of NUDT5 indicates poor prognosis of breast cancer by modulating AKT / Cyclin D signaling. [PDF]
PLoS One, 2021 Zhang H +7 more
europepmc +1 more source
A Mathematical Model of the Cell Cycle: Exploring the Impact of Zingerone on Cancer Cell Proliferation [PDF]
arXivThis paper presents a mathematical model that explores the interactions between Cyclin-Dependent Kinase 1 (CDK1) and the Anaphase-Promoting Complex (APC) in cancer cells. Through the analysis of a dynamical system simulating the CDK1-APC network, we investigate the system's behavior and its implications for cancer progression and potential therapeutic ...
arxiv
An Enhancer Trap Line Associated with a D-Class Cyclin Gene in Arabidopsis [PDF]
, 2000 Kankshita Swaminathan +4 more
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Molecule Generation for Target Protein Binding with Hierarchical Consistency Diffusion Model [PDF]
arXivEffective generation of molecular structures, or new chemical entities, that bind to target proteins is crucial for lead identification and optimization in drug discovery. Despite advancements in atom- and motif-wise deep learning models for 3D molecular generation, current methods often struggle with validity and reliability.
arxiv