Results 161 to 170 of about 592,070 (354)

Switching cyclin D-Cdk4 kinase activity on and off [PDF]

Cell Cycle, 2008
The cyclin-cdks are master regulators of cell proliferation. These serine/threonine kinases are the motors that both start and stop the cell cycle in response to proliferative or antiproliferative signals. They phosphorylate substrates required to trigger orderly cell cycle progression, and thus their activity is tightly regulated in order to prevent ...
openaire   +3 more sources

Cell cyclins: triggering elements of cancer or not?

World Journal of Surgical Oncology, 2010
Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the
Pateras Ioannis, Alexiou Ioannis, Xiromeritis Konstantinos, Karaiskos Ioannis, Palla Victoria, Stamatakos Michael, Kontzoglou Konstantinos   +6 more
doaj   +1 more source

Isolation of Drosophila cyclin D, a protein expressed in the morphogenetic furrow before entry into S phase. [PDF]

, 1996
Russell L. Finley, B J Thomas, S Lawrence Zipursky, Roger Brent   +3 more
openalex   +1 more source

The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D. [PDF]

Nature, 2021
Chaikovsky AC, Li C, Jeng EE, Loebell S, Lee MC, Murray CW, Cheng R, Demeter J, Swaney DL, Chen SH, Newton BW, Johnson JR, Drainas AP, Shue YT, Seoane JA, Srinivasan P, He A, Yoshida A, Hipkins SQ, McCrea E, Poltorack CD, Krogan NJ, Diehl JA, Kong C, Jackson PK, Curtis C, Petrov DA, Bassik MC, Winslow MM, Sage J.   +29 more
europepmc   +1 more source

Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2 [PDF]

, 2009
We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2 knock-out (Jdp2KO) mice by targeting exon 1 to disrupt ...
Atsushi Yoshiki, Hitomi Hasegawa, Jianzhi Pan, Kazunari K. Yokoyama, Koji Nakade, Naoto Yamaguchi, Satoko Masuzaki, Takehide Murata, Yu-Chang Huang, Yuichi Obata   +9 more
core   +1 more source

Asynchronous nuclear division cycles in multinucleated cells [PDF]

, 2006
Synchronous mitosis is common in multinucleated cells. We analyzed a unique asynchronous nuclear division cycle in a multinucleated filamentous fungus, Ashbya gossypii.
Gladfelter, A. S., Hungerbuehler, A. K., Philippsen, P.   +2 more
core   +2 more sources

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Inactivation of the Cyclin D-dependent Kinase in the Rat Fibroblast Cell Line, 3Y1, Induced by Contact Inhibition [PDF]

, 1997
Akira Kato, Hiroyuki Takahashi, Yuki Takahashi, Hitoshi Matsushime   +3 more
openalex   +1 more source

Expression of Concern for James et al., "Differential Modification of p27^Kip1 Controls Its Cyclin D-cdk4 Inhibitory Activity". [PDF]

Mol Cell Biol, 2022
American Society for Microbiology.
europepmc   +1 more source

Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels [PDF]

, 2010
In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in
Alexander M. Thomson, Berezney, Blasina, Blow, Blow, Boutros, Brown, Chong, Cohen, Dimitrova, Dimitrova, Dimitrova, Dimitrova, Donaldson, Eshaghi, Farkash-Amar, Feijoo, Ferenbach, Frouin, Ge, Gilbert, Goldberg, Goren, Hartley, Hayashi, Heichinger, Hiratani, Howe, J. Julian Blow, Jackson, Jeon, Karlsson-Rosenthal, Kitamura, Krasinska, Labit, Luciani, MacAlpine, Masumoto, Mickle, Moore, Nishitani, O'Keefe, Okuno, Peter J. Gillespie, Platani, Raghuraman, Raghuraman, Rempel, Santocanale, Sarkaria, Schübeler, Shechter, Shirahige, Strausfeld, Strausfeld, Swedlow, Tanaka, Vernon, White, Woodfine, Woodfine, Woodward, Wu, Zegerman, Zink   +64 more
core   +4 more sources