Results 161 to 170 of about 306,671 (274)

A cyclin D-CDK6 dimer helps to reshuffle cyclin-dependent kinase inhibitors (CKI) to overcome TGF-beta-mediated arrest and maintain CDK2 activity. [PDF]

Cell Cycle, 2021
Nataraj SE, Blain SW.
europepmc   +1 more source

NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression

Advanced Science, EarlyView.
NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu, Jixin Ma, Minwei Zhou, Xiaodong Gu, Yiming Zhou, Zhenyang Li, Tianyu Zhang, Wei Gong, Chuanxin Huang, Jianbin Xiang   +9 more
wiley   +1 more source

High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants

Nature Communications
Many regulatory protein-protein interactions depend on Short Linear Motifs (SLiMs). In the cell cycle, cyclin-CDKs recognize SLiMs to control substrate recruitment and phosphorylation timing.
Mihkel Örd, Matthew J. Winters, Mythili S. Subbanna, Natàlia de Martín Garrido, Victoria I. Cushing, Johanna Kliche, Caroline Benz, Ylva Ivarsson, Basil J. Greber, Peter M. Pryciak, Norman E. Davey   +10 more
doaj   +1 more source

Supplementary Figure 5 from A Novel Senescence-Evasion Mechanism Involving Grap2 and Cyclin D Interacting Protein Inactivation by Ras Associated with Diabetes in Cancer Cells under Doxorubicin Treatment

, 2023
In‐Kyoung Lee, Seon-Yong Yeom, Sook-Ja Lee, Won Ki Kang, Chaehwa Park   +4 more
openalex   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Cyclin D degradation by E3 ligases in cancer progression and treatment. [PDF]

Semin Cancer Biol, 2020
Qie S, Diehl JA.
europepmc   +1 more source

Expression of p21, p27, p53, cyclin D 1 and thymidylate synthase in squamous cell and mucoepidermoid carcinomas

, 2009
Kazuya Masuno, Tetsunari Nishikawa, Akio Tanaka   +2 more
openalex   +2 more sources

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway [PDF]

, 2010
Xinliang Mao, Biyin Cao, Tabitha E. Wood, Rose Hurren, Jiefei Tong, Xiaoming Wang, Wenjie Wang, Jie Li, Yueping Jin, Wenxian Sun, Paul A. Spagnuolo, Neil MacLean, Michael F. Moran, Alessandro Datti, Jeffery L. Wrana, Robert A. Batey, Aaron D. Schimmer   +16 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Features of Macrophage Differentiation Induced by p19INK4d, a Specific Inhibitor of Cyclin D–Dependent Kinases [PDF]

, 1997
Masashi Adachi, Martine F. Roussel, Karin Havenith, Charles J. Sherr   +3 more
openalex   +1 more source