Results 171 to 180 of about 15,468,838 (306)
Compact Origins and Where to Find Them: ORC's Guide to Genome‐Wide Licensing
BioEssays, EarlyView.Origin licensing is a key requirement for any eukaryotic cell to initiate DNA replication in S‐phase. Here, we review the most recent findings in the orchestrated action of the origin recognition complex (ORC) to sequentially load two MCM2‐7 helicases onto DNA with a focus on origin architecture and sequencing‐based methods.
Christian Speck +1 more
wiley +1 more source
Technology in Cancer Research & TreatmentBackground Transforming growth factor-β1 (TGF-β1) is an immunosuppressive cytokine that is highly expressed in the tumor microenvironment (TME) of lung adenocarcinoma (LUAD).
Xiaoling Lan PhD +4 more
doaj +1 more source
Cyclin D degradation by E3 ligases in cancer progression and treatment. [PDF]
Semin Cancer Biol, 2020 Qie S, Diehl JA.
europepmc +1 more source
Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer
BioEssays, EarlyView.Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley +1 more source
Dynamic protein interactions probed by NMR spectroscopy
Bulletin of the Korean Chemical Society, EarlyView.Abstract Dynamic protein–protein interactions are essential for diverse cellular processes but often evade structural characterization due to their transient, heterogeneous, and disordered nature. This review focuses on how nuclear magnetic resonance (NMR) spectroscopy can provide detailed, residue‐level insights into these complex interactions.
Jaeseok Lee, Jung Ho Lee
wiley +1 more source
The contribution of extracellular RNA and its derived biomaterials in disease management
BMEMat, EarlyView.The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei +8 more
wiley +1 more source
Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System
Cell Reports, 2017 Summary: Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated by the Cdc37-Hsp90 system.
Stephen T. Hallett +10 more
doaj
A cell‐cycle‐regulated kinase activity phosphorylates plant retinoblastoma protein and contains, in Arabidopsis, a CDKA/cyclin D complex [PDF]
, 2001 María Beatrice Boniotti +1 more
openalex +1 more source
BMEMat, EarlyView.This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan +12 more
wiley +1 more source
Ubiquitin/Proteasome-dependent Degradation of D-type Cyclins Is Linked to Tumor Necrosis Factor-induced Cell Cycle Arrest [PDF]
, 2002 Xiaotang Hu +7 more
openalex +1 more source