Results 11 to 20 of about 592,070 (354)
The regulation of cyclin D promoters – review
Cancer Treatment and Research Communications, 2021 Cyclins are key regulators of cell cycle progression and survival. Particularly cyclins D (cyclin D1, D2, and D3) act in response to the mitogenic stimulation and are pivotal mediators between proliferative pathways and the nuclear cell cycle machinery ...
Jan Pawlonka +2 more
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Cyclin D and cyclin E expression in normal and adenomatous pituitary [PDF]
European Journal of Endocrinology, 2000 OBJECTIVES: Cyclins play an important role in the regulation of cell progression through the cell cycle. Over-expression of the cyclins has been shown in many different tumour types. Pituitary adenomas are a common form of endocrine neoplasia in the human, but have been little studied in terms of the expression of the principal cyclins regulating ...
Suzanne Jordan +4 more
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Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins. [PDF]
Bioinformation, 2020 Piperine is a component of Piper nigrum (Black pepper). It is well known in ayurvedic formulations. Piperine is a bioenhancer as it reduces the activity of drug-metabolizing enzymes in rodents and thereby enhancing the plasma concentrations of several drugs, including the Pglycoprotein substrates.
Rekha UV +9 more
europepmc +4 more sources
Cyclin D in Left Ventricle Hypertrophy [PDF]
Cell Cycle, 2003 Left ventricle hypertrophy is induced by a number of stimuli and can lead to cardio-myopathy and heart failure. The hypertrophic response is achieved by enlargement of the cardiac myocytes and is regulated by multiple signaling pathways, with the D-type cyclins playing a crucial role.
Peter Kamp Busk, Rebecca Hinrichsen
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Cyclin E — a better prognostic marker for breast cancer than cyclin D? [PDF]
Nature Medicine, 1996 Q. Ping Dou +2 more
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D-Type Cyclins in Development and Disease
Genes, 2023 D-type cyclins encode G1/S cell cycle checkpoint proteins, which play a crucial role in defining cell cycle exit and progression. Precise control of cell cycle exit is vital during embryonic development, with defects in the pathways regulating intracellular D-type cyclins resulting in abnormal initiation of stem cell differentiation in a variety of ...
Mostafa Saleban +2 more
openaire +2 more sources
Molecular Medicine, 2022 Background Deficient endometrial decidualization has been associated with URSA. However, the underlying mechanism is poorly understood. This study aimed to investigate the temporal cytokine changes and the involvement of CyclinD-CDK4/6 and CyclinE-CDK2 ...
Zhuo Chang +13 more
doaj +1 more source
Haematologica, 2023 Upregulation of a cyclin D gene determined by expression microarrays is an almost universal event in multiple myeloma (MM), but this finding has not been properly confirmed at the protein level. For this reason, we carried out a quantitative analysis of
Ignacio J. Cardona-Benavides +15 more
doaj +1 more source
D cyclins in lymphocytes [PDF]
Cytometry Part A, 2004 AbstractBackgroundD cyclins are essential for the progression of cells through the G1 phase of the cell cycle. There are three distinct D cyclins. Cyclin D1 has been shown to be expressed by many different types of cells but not by lymphocytes. Cyclins D2 and D3 have been found in lymphocytes.MethodsWe used high‐resolution enzymatic amplification ...
William Husel +4 more
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Arabidopsis D-Type Cyclin CYCD4;1 Is a Novel Cyclin Partner of B2-Type Cyclin-Dependent Kinase [PDF]
Plant Physiology, 2003 Abstract B-type cyclin-dependent kinases (CDKs) are unique to plants and are assumed to be involved in the control of the G2-to-M phase progression and mitotic events. However, little is known about their cyclin partners. In Arabidopsis, we isolated cDNA encoding the D-type cyclin CYCD4;1 by a yeast (Saccharomyces cerevisiae) two-hybrid ...
Atsushi Kono +5 more
openalex +5 more sources