AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. [PDF]
Nature, 2021 Mammalian development, adult tissue homeostasis and the avoidance of severe diseases including cancer require a properly orchestrated cell cycle, as well as error-free genome maintenance.
Maiani E +45 more
europepmc +5 more sources
Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix. [PDF]
Mol Cell, 2019 The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by ...
Topacio BR +8 more
europepmc +3 more sources
The regulation of cyclin D promoters – review
Cancer Treatment and Research Communications, 2021 Cyclins are key regulators of cell cycle progression and survival. Particularly cyclins D (cyclin D1, D2, and D3) act in response to the mitogenic stimulation and are pivotal mediators between proliferative pathways and the nuclear cell cycle machinery.
Jan Pawlonka +2 more
openaire +3 more sources
Cell Cycle Progression without Cyclin D-CDK4 and Cyclin D-CDK6 Complexes [PDF]
Cell Cycle, 2005 D-type cyclins (cyclin D1, D2 and D3) and their associated cyclin-dependent kinases CDK4 and CDK6 were thought to represent important, perhaps essential components of the core cell cycle apparatus. However, recent analyses of mice lacking D-cyclins, or CDK4 and CDK6 reveal that these proteins are critically required for proliferation only in the ...
Katarzyna Kozar, Piotr Sicinski
openaire +3 more sources
The double dealing of cyclin D1 [PDF]
Cell Cycle, Taylor & Francis, 2010, pp.1-16, 2020 The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression.
arxiv +1 more source
HIV-1 expression induces cyclin D(1) expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy [PDF]
, 2002 BACKGROUND: The aberrant cell-cycle progression of HIV-1-infected kidney cells plays a major role in the pathogenesis of HIV-associated nephropathy, however the mechanisms whereby HIV-1 induces infected glomerular podocytes or infected tubular epithelium
Gelman, Irwin H +3 more
core +3 more sources
Cyclin D associated events in G1 [PDF]
Reactome - a curated knowledgebase of biological pathways, 2017 info:eu-repo/semantics ...
D'EUSTACHIO, P +9 more
openaire +3 more sources
Cellular responses to ionising radiation in multiple myeloma: Influence of D-type cyclin and IgH translocation [PDF]
, 2022 Multiple myeloma (MM) is characterized by over-expression of cyclin D1 or D2, which control G1 phase cell-cycle progression. Proteolytic degradation of cyclin D1 (but not cyclin D2), resulting in G1 arrest, is reported in non-MM cells postDNA damage ...
Smith, Dean Edward
core
The membrane-associated form of cyclin D1 enhances cellular invasion [PDF]
, 2020 The essential G1-cyclin, CCND1, is a collaborative nuclear oncogene that is frequently overexpressed in cancer. D-type cyclins bind and activate CDK4 and CDK6 thereby contributing to G1–S cell-cycle progression.
Achilefu, S +14 more
core +4 more sources
Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]
, 2019 Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G. +5 more
core +2 more sources