Results 11 to 20 of about 306,671 (274)

Genetic alterations of Cyclin D-CDK4/6-INK4-RB pathway in prostate cancer. [PDF]

open access: hybridMol Biol Rep
Sivoňová MK   +10 more
europepmc   +3 more sources

Alleviation of cisplatin-induced hepatotoxicity and nephrotoxicity by L-carnitine [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2022
Objective(s): To assess the protective effect of L-carnitine in reducing cisplatin toxicity via estimating biochemical tests, histomorphometric, and immunohistochemistry (IHC) of β-catenin and cyclin D.Materials and Methods: Fifteen adult male rabbits ...
snur Hassan   +3 more
doaj   +1 more source

Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins. [PDF]

open access: hybridBioinformation, 2020
Rekha UV   +9 more
europepmc   +3 more sources

The regulation of cyclin D promoters – review

open access: yesCancer Treatment and Research Communications, 2021
Cyclins are key regulators of cell cycle progression and survival. Particularly cyclins D (cyclin D1, D2, and D3) act in response to the mitogenic stimulation and are pivotal mediators between proliferative pathways and the nuclear cell cycle machinery ...
Jan Pawlonka   +2 more
doaj   +1 more source

Temporal changes in cyclinD-CDK4/CDK6 and cyclinE-CDK2 pathways: implications for the mechanism of deficient decidualization in an immune-based mouse model of unexplained recurrent spontaneous abortion

open access: yesMolecular Medicine, 2022
Background Deficient endometrial decidualization has been associated with URSA. However, the underlying mechanism is poorly understood. This study aimed to investigate the temporal cytokine changes and the involvement of CyclinD-CDK4/6 and CyclinE-CDK2 ...
Zhuo Chang   +13 more
doaj   +1 more source

Quantification of cyclin D1 and D2 proteins in multiple myeloma identifies different expression patterns from those revealed by gene expression profiling

open access: yesHaematologica, 2023
Upregulation of a cyclin D gene determined by expression microarrays is an almost universal event in multiple myeloma (MM), but this finding has not been properly confirmed at the protein level. For this reason, we carried out a quantitative analysis of
Ignacio J. Cardona-Benavides   +15 more
doaj   +1 more source

An overview of CDK3 in cancer: clinical significance and pharmacological implications

open access: yesPharmacological Research, 2022
Cyclin-dependent kinase 3 (CDK3) is a major player driving retinoblastoma (Rb) phosphorylation during the G0/G1 transition and in the early G1 phase of the cell cycle, preceding the effects of CDK4/cyclin D, CDK6/cyclin D, and CDK2/cyclin E.
Theodosia Teo   +5 more
doaj   +1 more source

Research Progress of CDK4/6 Inhibitors in Non-small Cell Lung Cancer

open access: yesChinese Journal of Lung Cancer, 2020
Lung cancer is the leading cause of cancer-related death worldwide. Non-small cell lung cancer (NSCLC) accounts for 80%-85% of lung cancer. Malignant tumors can proliferate indefinitely, and cell cycle regulation is abnormal which is one of the ...
Qiong QIN, Yaoyao REN, Diansheng ZHONG
doaj   +1 more source

The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis

open access: yesFrontiers in Oncology, 2022
The sterol regulatory-element binding protein (SREBP) family of transcription factors regulates cholesterol, fatty acid, and triglyceride synthesis and metabolism.
Arwa Aldaalis   +3 more
doaj   +1 more source

Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]

open access: yes, 2019
Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G.   +5 more
core   +2 more sources

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