Results 211 to 220 of about 592,070 (354)

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

« Cycler » sans cycline D [PDF]

médecine/sciences, 2005
openaire   +4 more sources

Involvement of the D-Type Cyclins in Germ Cell Proliferation and Differentiation in the Mouse1 [PDF]

, 2000
Tim L. Beumer, Hermien L. Roepers‐Gajadien, Iris S. Gademan, Henk B. Kal, Dirk G. de Rooij   +4 more
openalex   +1 more source

A cyclin D-CDK6 dimer helps to reshuffle cyclin-dependent kinase inhibitors (CKI) to overcome TGF-beta-mediated arrest and maintain CDK2 activity. [PDF]

Cell Cycle, 2021
Nataraj SE, Blain SW.
europepmc   +1 more source

PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer

Advanced Science, EarlyView.
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li, Xinran Dong, Kexing Gao, Yiyang Wang, Min Li, Huayun Deng, Shuangyu Ma, Yaping Lv, Wei Jin, Quanfu Li, Yuming Wang, Xiaodong Liao, Kangjing Bian, Aiwu Zhou, Chengping Hu, Lei Huang   +15 more
wiley   +1 more source

Single‐Cell Transcriptome Reveals Aquaporin‐Mediated Carbon Nanosol‐Induced Growth Promotion of Plants

Advanced Science, EarlyView.
Carbon nanosol (CNS) exhibits rapid root penetration capacity, enhancing plant growth through boosting stomatal density and antioxidative enzyme activity. Single‐cell transcriptomic profiling uncovers cell type‐specific gene expression patterns and developmental trajectories during CNS‐mediated growth promotion.
Lingtong Cheng, Zechao Qu, Qiansi Chen, Lin Wang, Huan Su, Jiemeng Tao, Peng Lu, Taibo Liang, Jianfeng Zhang, Peijian Cao, Jingjing Jin   +10 more
wiley   +1 more source

Assessment of cyclin D1 activity in tumors and tumor budding and its prognostic significance in tumor budding in colorectal carcinomas

Indian Journal of Pathology and Microbiology
Background: The most important prognostic parameter is staging in colorectal cancers, and tumor budding (TB) is among the independent prognostic parameters that are increasing in significance.
Ganime Coban, Dilek S. Arici, Busra C. Tekden, Pelin Yildiz, Tugce Kiran, Özlem Toluk, Haci M. Turk, Nurhan Şahin   +7 more
doaj   +1 more source

GCIP, a Novel Human Grap2 and Cyclin D Interacting Protein, Regulates E2F-mediated Transcriptional Activity [PDF]

, 2000
Chunzhi Xia, Zhenmin Bao, Fazal H. Tabassam, Wenbin Ma, Mengsheng Qiu, Shao-bing Hua, Mingyao Liu   +6 more
openalex   +1 more source

Tβ4‐Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing

Advanced Science, EarlyView.
A separable microneedle patch is designed for Tβ4–modified ADSC‐derived extracellular vesicles delivery. The overexpressed Tβ4 released from the microneedles can mitigate cellular senescence and promote wound healing via the PTEN/PI3K/AKT pathway, offering a promising approach for diabetic wound treatment. This bioengineered therapeutic system serve as
Youjun Ding, Jinglin Wang, Jiaye Li, Yi Cheng, Shuyin Zhou, Yepeng Zhang, Yuanjin Zhao, Min Zhou   +7 more
wiley   +1 more source

Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb

, 1998
Christine Neuveut, Kenneth G. Low, Frank Maldarelli, Iris Schmitt, Franca Majone, Ralph Grassmann, Kuan‐Teh Jeang   +6 more
openalex   +1 more source