Results 221 to 230 of about 592,070 (354)
Murine Gammaherpesvirus 68 Cyclin D Homologue Is Required for Efficient Reactivation from Latency [PDF]
, 2000 Ann T. Hoge +2 more
openalex +1 more source
Advanced Intelligent Systems, EarlyView.This study develops a deep learning‐based pipeline named π‐PhenoDrug for cell phenotype‐driven drug activity screening. π‐PhenoDrug integrates cell segmentation, morphological profile construction, and phenotype analysis modules, and it can assess drug effects on living cells in both supervised and unsupervised modes.
Xiao Li +7 more
wiley +1 more source
Technology in Cancer Research & TreatmentBackground Transforming growth factor-β1 (TGF-β1) is an immunosuppressive cytokine that is highly expressed in the tumor microenvironment (TME) of lung adenocarcinoma (LUAD).
Xiaoling Lan PhD +4 more
doaj +1 more source
An Enhancer Trap Line Associated with a D-Class Cyclin Gene in Arabidopsis [PDF]
, 2000 Kankshita Swaminathan +4 more
openalex +1 more source
Growth Charts for Children With Beckwith–Wiedemann Spectrum
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Beckwith–Wiedemann spectrum (BWSp) is an overgrowth disorder caused by (epi)genetic alterations in chromosome 11p15. This study aimed to develop BWSp‐specific growth charts and explore genotype/phenotype correlations with respect to growth. Heights, weights, and head circumferences were retrospectively collected from 581 individuals with BWSp ...
Saskia M. Maas +11 more
wiley +1 more source
Cyclin D degradation by E3 ligases in cancer progression and treatment. [PDF]
Semin Cancer Biol, 2020 Qie S, Diehl JA.
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai +7 more
wiley +1 more source
Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System
Cell Reports, 2017 Summary: Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated by the Cdc37-Hsp90 system.
Stephen T. Hallett +10 more
doaj
A cell‐cycle‐regulated kinase activity phosphorylates plant retinoblastoma protein and contains, in Arabidopsis, a CDKA/cyclin D complex [PDF]
, 2001 María Beatrice Boniotti +1 more
openalex +1 more source
Approaches to repurposing reverse transcriptase antivirals in cancer
British Journal of Clinical Pharmacology, EarlyView.This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head +2 more
wiley +1 more source