BMC Microbiology, 2002 Background The aberrant cell-cycle progression of HIV-1-infected kidney cells plays a major role in the pathogenesis of HIV-associated nephropathy, however the mechanisms whereby HIV-1 induces infected glomerular podocytes or infected tubular epithelium ...
Husain Mohammad +3 more
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Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells. [PDF]
PLoS Genetics, 2011 Cell proliferation and differentiation are regulated in a highly coordinated and inverse manner during development and tissue homeostasis. Terminal differentiation usually coincides with cell cycle exit and is thought to engage stable transcriptional ...
Jerome Korzelius +9 more
doaj +1 more source
Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress. [PDF]
, 2015 Mitochondrial dysfunction has been implicated in human diseases, including cancer, and proposed to accelerate aging. The Drosophila Cyclin-dependent protein kinase complex cyclin D/cyclin-dependent kinase 4 (CycD/Cdk4) promotes cellular growth by ...
de la Cruz, Aida Flor A +3 more
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Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent manner [PDF]
, 2011 Neural stem and progenitor cells undergo an important transition from proliferation to differentiation in the G1 phase of the cell cycle. The mechanisms coordinating this transition are incompletely understood.
A. I. Lukaszewicz +46 more
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Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle [PDF]
, 2015 The human hair follicle (HF) exhibits peripheral clock activity, with knock-down of clock genes (BMAL1 and PER1) prolonging active hair growth (anagen) and increasing pigmentation.
Farjo, Bessam +4 more
core +11 more sources
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation [PDF]
, 1993 In normal human diploid fibroblasts, cyclins of the A, B, and D classes each associate with cyclin-dependent kinases (CDKs), proliferating cell nuclear antigen (PCNA), and p21, thereby forming multiple independent quaternary complexes.
Beach, D., Xiong, Y., Zhang, H.
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Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells
Cell Reports, 2020 Summary: Germinal center (GC) B cells surge in their proliferative capacity, which poses a direct risk for B cell malignancies. G1- to S-phase transition is dependent on the expression and stability of D-type cyclins.
Parham Ramezani-Rad +3 more
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Expression of D-type cyclins in differentiating cells of the mouse spinal cord
Genetics and Molecular Biology, 2007 The D-type cyclins form complexes with the cyclin dependent (CD) kinases CDK4 and CDK6 and promote the G1-S phase transition of the cell cycle by antagonizing the retinoblastoma suppresser protein pRB. In the developing nervous system D-type cyclins show
Patricy de Andrade Salles +3 more
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Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma [PDF]
, 2010 Background The Sonic hedgehog (Shh) signaling pathway is critical for cell growth and differentiation. Impairment of this pathway can result in both birth defects and cancer.
Afzal, Mohammad +6 more
core +5 more sources
New twist in the regulation of cyclin D1
Biomolecular Concepts, 2010 Among the cell cycle-related mammalian cyclins, cyclin D1 is more closely connected with cell proliferation in response to extracellular signals than the cell cycle clock itself.
Kato Jun-ya, Yoneda-Kato Noriko
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