Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation [PDF]
, 1993 In normal human diploid fibroblasts, cyclins of the A, B, and D classes each associate with cyclin-dependent kinases (CDKs), proliferating cell nuclear antigen (PCNA), and p21, thereby forming multiple independent quaternary complexes.
Beach, D., Xiong, Y., Zhang, H.
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Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress. [PDF]
, 2015 Mitochondrial dysfunction has been implicated in human diseases, including cancer, and proposed to accelerate aging. The Drosophila Cyclin-dependent protein kinase complex cyclin D/cyclin-dependent kinase 4 (CycD/Cdk4) promotes cellular growth by ...
de la Cruz, Aida Flor A +3 more
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JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21 [PDF]
, 2017 Cyclin D-CDK4/6 are the first cyclin-dependent kinase (CDK) complexes to be activated by mitogenic/oncogenic pathways. They have a central role in the cell multiplication decision and in its deregulation in cancer cells.
Bisteau, X. +7 more
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The critical role of cyclin D2 in adult neurogenesis [PDF]
, 2004 Adult neurogenesis (i.e., proliferation and differentiation of neuronal precursors in the adult brain) is responsible for adding new neurons in the dentate gyrus of the hippocampus and in the olfactory bulb.
Ciemerych, Maria A. +8 more
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The Braid Indices of the Reverse Parallel Links of Alternating Knots [PDF]
Algebr. Geom. Topol. 24 (2024) 2957-2970, 2023 The braid indices of most links remain unknown as there is no known universal method that can be used to determine the braid index of an arbitrary knot. This is also the case for alternating knots. In this paper, we show that if $K$ is an alternating knot, then the braid index of any reverse parallel link of $K$ can be precisely determined.
arxiv +1 more source
Regulation of the human cyclin C gene via multiple vitamin D(3)-responsive regions in its promoter [PDF]
, 2005 The candidate human tumor suppressor gene cyclin C is a primary target of the anti-proliferative hormone 1α,25-dihydroxyvitamin D(3) [1α,25(OH)(2)D(3)], but binding sites for the 1α,25(OH)(2)D(3) receptor (VDR), so-called 1α,25(OH)(2)D(3) response ...
Carlberg, Carsten +4 more
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Inhibition of cell cycle progression by dual phosphatidylinositol-3-kinase and mTOR blockade in cyclin D2 positive multiple myeloma bearing IgH translocations [PDF]
, 2012 Multiple myeloma (MM) is a clinically and genetically heterogenous cancer where tumour cells have dysregulated expression of a D-type cyclin, often in association with a recurrent IgH translocation. Patients whose tumour cells express cyclin D2, with the
Glassford, J +6 more
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Immunodetectable cyclin D 1 is associated with oestrogen receptor but not Ki67 in normal, cancerous and precancerous breast lesions [PDF]
, 2001 Cyclin D1 is associated with cell cycle regulation and has more recently been shown to stimulate the transcriptional functions of the oestrogen receptor (ER).
Davies, M P A +5 more
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The Discovery of Plant D-Type Cyclins [PDF]
The Plant Cell, 2019 Across all eukaryotes, cell cycle progression is controlled by heterodimeric protein complexes composed of a Ser/Thr-specific cyclin-dependent kinase (CDK) and cyclin, a regulatory subunit that controls both the timing of CDK activation and its substrate specificity.
openaire +3 more sources
Signaling through cyclin D-dependent kinases [PDF]
Oncogene, 2013 Research over the past quarter century has identified cyclin D-dependent kinases, CDK4 and CDK6, as the major oncogenic drivers among members of the CDK superfamily. CDK4/6 are rendered hyperactive in the majority of human cancers through a multitude of genomic alterations.
L Anders, Y J Choi
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