Results 31 to 40 of about 584,094 (211)

Caenorhabditis elegans Cyclin D/CDK4 and Cyclin E/CDK2 Induce Distinct Cell Cycle Re-Entry Programs in Differentiated Muscle Cells [PDF]

, 2011
Cell proliferation and differentiation are regulated in a highly coordinated and inverse manner during development and tissue homeostasis. Terminal differentiation usually coincides with cell cycle exit and is thought to engage stable transcriptional ...
A Blais, A Fire, A Raj, A Salic, Andrew D. Chisholm, C Frokjaer-Jensen, C Sage, CA Meyer, CJ Sherr, D Cobrinik, DG Moerman, F Bienvenu, Frank C. P. Holstege, GF Berriz, I Ajioka, Inge The, J Kim, J Korzelius, J Korzelius, JE Sulston, JE Sulston, Jerome Korzelius, JJ Jacobs, LA Buttitta, LA Buttitta, LA Buttitta, M Boxem, M Boxem, M Boxem, M Park, Marian J. Groot Koerkamp, Martine B. W. Prinsen, Mike Boxem, MR Van Gilst, N Mailand, NV Kirienko, PJ Roy, RJ Duronio, RM Fox, RM Saito, S van den Heuvel, SA Datar, Sander van den Heuvel, SE Wirt, SH Buck, Suzan Ruijtenberg, T Fukushige, Teije C. Middelkoop, Vincent Portegijs, X Lu, XL Xu, Y Hong   +51 more
core   +7 more sources

OpenMM 8: Molecular Dynamics Simulation with Machine Learning Potentials [PDF]

arXiv, 2023
Machine learning plays an important and growing role in molecular simulation. The newest version of the OpenMM molecular dynamics toolkit introduces new features to support the use of machine learning potentials. Arbitrary PyTorch models can be added to a simulation and used to compute forces and energy.
arxiv  

Herpes Simplex Virus Type 1 Infection Imposes a G1/S Block in Asynchronously Growing Cells and Prevents G1 Entry in Quiescent Cells [PDF]

, 2000
Herpes simplex virus type 1 (HSV-1) infection disrupted cell cycle regulation in at least two ways. First, infection of quiescent human embryonic lung cells simultaneously with readdition of serum caused inhibition of cyclin D/cyclin-dependent kinase ...
Bachenheimer, Steven L., Ehmann, Ginger L., McLean, Tim I.   +2 more
core   +2 more sources

Cyclin D [PDF]

, 2006
D type cyclins belong to a family of related proteins that bind to and activate several protein kinases named cyclin-dependent kinases (CDKs), which are involved in regulation of the cell division cycle.
openaire   +2 more sources

Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis. [PDF]

, 2018
There is remarkable redundancy between the Cyclin-Cdk complexes that comprise the cell cycle machinery. None of the mammalian A-, D-, or E-type cyclins are required in development until implantation, and only Cdk1 is essential for early cell divisions ...
Andrew Harrison, Bellanger, Bernhard Strauss, Bischoff, Bolton, Brandeis, Castilho, Chang, Ciemerych, Clegg, Day, Draviam, Enoch, Gavet, Gavet, Geng, Gharbi-Ayachi, Gong, Gong, Goval, Hagting, Hamatani, Hirai, Jackman, Jacobs, Jedrusik, Jin, Jonathon Pines, Kalaszczynska, Keiko Yata, Kozar, Lehner, Leonhardt, Li, Lindqvist, Liu, Liu, Lykke-Andersen, Magdalena Zernicka-Goetz, Malumbres, Mochida, Moore, Morgan, Murphy, Nguyen, Noton, O’Connell, Paula Almeida Coelho, Russell, Santamaría, Santos, Soni, Streffer, Toyoshima, van Vugt, Wang, Yang, Zernicka-Goetz   +57 more
core   +3 more sources

Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent manner [PDF]

, 2011
Neural stem and progenitor cells undergo an important transition from proliferation to differentiation in the G1 phase of the cell cycle. The mechanisms coordinating this transition are incompletely understood.
A. I. Lukaszewicz, Altman, Bae, Bertrand, Bienvenu, Briscoe, Budirahardja, Bylund, Bystron, Calegari, Cremisi, D. J. Anderson, Dasen, Dehay, Dehay, Donovan, Fior, Glover, Gui, Hinds, Humbert, Huttner, Jhas, Kageyama, Kerkhoff, Koyano-Nakagawa, Kuida, Lange, Lobjois, Lukaszewicz, Ma, Massagu  , Megason, Mizutani, O'Leary, Ohnuma, Perez, Rao, Rao, Roztocil, Sherr, Tanabe, Tsuchida, Ulloa, White, Zhao, Zhou   +46 more
core   +3 more sources

Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation [PDF]

, 2018
p27$^{Kip1}$ (p27) is an intrinsically disordered protein (IDP) that folds upon binding to cyclin-dependent kinase (Cdk)$/$cyclin complexes (e.g., Cdk2$/$cyclin A), inhibiting their catalytic activity and causing cell cycle arrest. However, cell division progresses when stably Cdk2$/$cyclin A-bound p27 is phosphorylated on one or two structurally ...
arxiv   +1 more source

Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation. [PDF]

, 2017
Rearrangement and amplification of the D-type cyclin genes have been reported in human cancer. Previous studies have demonstrated that Ras-mediated skin tumorigenesis depends on pathways that act through cyclin D1 and D2; however, the role of cyclin D3 ...
Kim, S.H., Kim, Y., Lee, S.H., Rodriguez-Puebla, M.L., Wang, X.   +4 more
core   +1 more source

Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C. [PDF]

, 2019
The anaphase-promoting complex/cyclosome (APC/C) orchestrates cell cycle progression by controlling the temporal degradation of specific cell cycle regulators.
Barford, David, Tischer, Thomas, Zhang, Suyang   +2 more
core   +2 more sources

Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations [PDF]

Journal of Medicinal Chemistry 49, 5141-5153 (2006), 2008
The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to ...
arxiv   +1 more source