Results 31 to 40 of about 592,070 (354)
The requirement for cyclin D function in tumor maintenance. [PDF]
Cancer Cell, 2012 D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains that allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D-associated kinase activity in mice bearing ErbB2-driven mammary ...
Choi YJ +10 more
europepmc +5 more sources
Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent manner [PDF]
, 2011 Neural stem and progenitor cells undergo an important transition from proliferation to differentiation in the G1 phase of the cell cycle. The mechanisms coordinating this transition are incompletely understood.
A. I. Lukaszewicz +46 more
core +3 more sources
Expression of D-type cyclins in differentiating cells of the mouse spinal cord
Genetics and Molecular Biology, 2007 The D-type cyclins form complexes with the cyclin dependent (CD) kinases CDK4 and CDK6 and promote the G1-S phase transition of the cell cycle by antagonizing the retinoblastoma suppresser protein pRB. In the developing nervous system D-type cyclins show
Patricy de Andrade Salles +3 more
doaj +1 more source
Journal of International Medical Research, 2022 Objectives To explore the impacts of 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) on the proliferation, migration, and monocyte chemoattractant protein-1 (MCP-1) secretion of vascular smooth muscle cells (VSMCs) in a high glucose environment and its ...
Xu Kaizu +3 more
doaj +1 more source
Cyclin-Dependent Kinase 4 and 6 Inhibitors in Cell Cycle Dysregulation for Breast Cancer Treatment
Molecules, 2021 In cell development, the cell cycle is crucial, and the cycle progression’s main controllers are endogenous CDK inhibitors, cyclin-dependent kinases (CDKs), and cyclins. In response to the mitogenic signal, cyclin D is produced and retinoblastoma protein
Ni Made Pitri Susanti +1 more
doaj +1 more source
Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation. [PDF]
, 2017 Rearrangement and amplification of the D-type cyclin genes have been reported in human cancer. Previous studies have demonstrated that Ras-mediated skin tumorigenesis depends on pathways that act through cyclin D1 and D2; however, the role of cyclin D3 ...
Kim, S.H. +4 more
core +1 more source
New twist in the regulation of cyclin D1
Biomolecular Concepts, 2010 Among the cell cycle-related mammalian cyclins, cyclin D1 is more closely connected with cell proliferation in response to extracellular signals than the cell cycle clock itself.
Kato Jun-ya, Yoneda-Kato Noriko
doaj +1 more source
ISCC (Indonesian Journal of Cancer Chemoprevention), 2016 Hedyotis corymbosa has been used for long time as an important component in several folklore medicine formula to clinically treat various types of cancer, including colorectal cancer (CRC).
Argandita Meiftasari +4 more
doaj +1 more source
Molecular Oncology, 2023 Cyclin‐dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by distinctive structural features, but their partner CDKs ...
Eva Quandt +16 more
doaj +1 more source
The Braid Indices of the Reverse Parallel Links of Alternating Knots [PDF]
Algebr. Geom. Topol. 24 (2024) 2957-2970, 2023 The braid indices of most links remain unknown as there is no known universal method that can be used to determine the braid index of an arbitrary knot. This is also the case for alternating knots. In this paper, we show that if $K$ is an alternating knot, then the braid index of any reverse parallel link of $K$ can be precisely determined.
arxiv +1 more source