Overexpression of Mouse D-Type Cyclins Accelerates G(1) Phase in Rodent Fibroblasts [PDF]
, 1993 Mammalian D-type cyclins are growth factor-regulated, delayed early response genes that are presumed to control progression through the G1 phase of the cell cycle by governing the activity of cyclin-dependent kinases (cdks).
Ashmun, R. A. +6 more
core +1 more source
Expression of Cyclin-D1 in Astrocytes Varies During Aging
Frontiers in Aging Neuroscience, 2018 D-Cyclins control progression through the G1 phase and the G1/S transition of the cell cycle. In the adult brain, they regulate neurogenesis which is limited to the sub-granular zone of the dentate gyrus (DG) and to the sub-ventricular zone (SVZ) of the ...
Brigitte Ciapa, Sylvie Granon
doaj +1 more source
Stem Cells International, 2023 Ginsenoside Rg1 (Rg1) is purified from ginseng with various pharmacological effects, which might facilitate the biological behavior of human amnion-derived mesenchymal stem/stromal cells (hAD-MSCs). This study is aimed at investigating the effects of Rg1
Li Ling +4 more
doaj +1 more source
A conserved but plant-specific CDK-mediated regulation of DNA replication protein A2 in the precise control of stomatal terminal division [PDF]
, 2019 The R2R3-MYB transcription factor FOUR LIPS (FLP) controls the stomatal terminal division through transcriptional repression of the cell cycle genes CYCLIN-DEPENDENT KINASE (CDK) B1s (CDKB1s), CDKA; 1, and CYCLIN A2s (CYCA2s).
Dong, Juan +8 more
core +2 more sources
The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells [PDF]
, 2015 International audienceAbstractBackgroundThe family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual
Azogui, Orly +10 more
core +9 more sources
The Discovery of Plant D-Type Cyclins [PDF]
The Plant Cell, 2019 Across all eukaryotes, cell cycle progression is controlled by heterodimeric protein complexes composed of a Ser/Thr-specific cyclin-dependent kinase (CDK) and cyclin, a regulatory subunit that controls both the timing of CDK activation and its substrate specificity.
openaire +3 more sources
Cellular responses to ionising radiation in multiple myeloma: Influence of D-type cyclin and IgH translocation [PDF]
, 2022 Multiple myeloma (MM) is characterized by over-expression of cyclin D1 or D2, which control G1 phase cell-cycle progression. Proteolytic degradation of cyclin D1 (but not cyclin D2), resulting in G1 arrest, is reported in non-MM cells postDNA damage ...
Smith, Dean Edward
core
Signaling through cyclin D-dependent kinases [PDF]
Oncogene, 2013 Research over the past quarter century has identified cyclin D-dependent kinases, CDK4 and CDK6, as the major oncogenic drivers among members of the CDK superfamily. CDK4/6 are rendered hyperactive in the majority of human cancers through a multitude of genomic alterations.
L Anders, Y J Choi
openaire +3 more sources
OpenMM 8: Molecular Dynamics Simulation with Machine Learning Potentials [PDF]
arXiv, 2023 Machine learning plays an important and growing role in molecular simulation. The newest version of the OpenMM molecular dynamics toolkit introduces new features to support the use of machine learning potentials. Arbitrary PyTorch models can be added to a simulation and used to compute forces and energy.
arxiv
Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma [PDF]
, 2010 Background The Sonic hedgehog (Shh) signaling pathway is critical for cell growth and differentiation. Impairment of this pathway can result in both birth defects and cancer.
Afzal, Mohammad +6 more
core +5 more sources