Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4 [PDF]
Genes & Development, 1993 The product (pRb) of the retinoblastoma gene (RB-1) prevents S-phase entry during the cell cycle, and inactivation of this growth-suppressive function is presumed to result from pRb hyperphosphorylation during late G1 phase. Complexes of the cyclin-dependent kinase, cdk4, and each of three different D-type cyclins, assembled in insect Sf9 cells ...
Scott W. Hiebert +4 more
openaire +2 more sources
A conserved but plant-specific CDK-mediated regulation of DNA replication protein A2 in the precise control of stomatal terminal division [PDF]
, 2019 The R2R3-MYB transcription factor FOUR LIPS (FLP) controls the stomatal terminal division through transcriptional repression of the cell cycle genes CYCLIN-DEPENDENT KINASE (CDK) B1s (CDKB1s), CDKA; 1, and CYCLIN A2s (CYCA2s).
Dong, Juan +8 more
core +2 more sources
Analysis of strong decays of the charmed mesons D(2550), D(2600), D(2750) and D(2760) [PDF]
Phys.Rev.D83:014009,2011, 2010 In this article, we study the strong decays of the newly observed charmed mesons $D(2550)$, $D(2600)$, $D(2750)$ and $D(2760)$ with the heavy quark effective theory in the leading order approximation, and tentatively identify the $(D(2550),D(2600))$ as the $2S$ doublet $(0^-,1^-)$ and the $(D(2750),D(2760))$ as the $1D$ doublet $(2^-,3 ...
arxiv +1 more source
Fbxo7 Gets Proactive with Cyclin D/cdk6 [PDF]
Cell Cycle, 2006 Although all three D cyclins bind and activate cdks 2, 4 and 6, Fbxo7 has been characterised as a selective enhancer of cdk6 activity. It increases activation by directly facilitating cdk6 interaction with viral and cellular D cyclins. Fbxo7 overexpression has transforming activity in murine fibroblasts, and it is also highly expressed in human cancers,
openaire +2 more sources
The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix [PDF]
, 2005 BACKGROUND: The Tax oncoprotein of human T-cell leukemia virus type 1 (HTLV-1) is leukemogenic in transgenic mice and induces permanent T-cell growth in vitro. It is found in active CDK holoenzyme complexes from adult T-cell leukemia-derived cultures and
Fraedrich, Kirsten +2 more
core +2 more sources
Lineage specific composition of cyclin D–CDK4/CDK6–p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin [PDF]
Objectives: This article is to study the role of G1/S regulators in differentiation of pluripotent embryonic cells. Materials and methods: We established a P19 embryonal carcinoma cell-based experimental system, which profits from two similar ...
A. Hampl +17 more
core +2 more sources
AlphaFold Accelerates Artificial Intelligence Powered Drug Discovery: Efficient Discovery of a Novel Cyclin-dependent Kinase 20 (CDK20) Small Molecule Inhibitor [PDF]
arXiv, 2022 The AlphaFold computer program predicted protein structures for the whole human genome, which has been considered as a remarkable breakthrough both in artificial intelligence (AI) application and structural biology. Despite the varying confidence level, these predicted structures still could significantly contribute to structure-based drug design of ...
arxiv
Selective usage of D-type cyclins in lymphoid malignancies [PDF]
Leukemia, 1999 Three D-type cyclins, cyclin D1, D2 and D3, belong to the G1 cyclin, which regulates the G1/S transition of the cell cycle, and feature highly homologous amino acid sequences. The cyclin D1 gene was found to be transcriptionally activated in B-lymphoid malignancies with t(11;14), but available information is limited regarding expression of cyclin D2 ...
Yasuo Morishima +10 more
openaire +3 more sources
The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells [PDF]
, 2015 International audienceAbstractBackgroundThe family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual
Azogui, Orly +10 more
core +9 more sources
Cycline subalgebras of $k$-graph C*-algebras [PDF]
arXiv, 2015 In this paper, we prove that the cycline subalgbra of a $k$-graph C*-algebra is maximal abelian, and show when it is a Cartan subalgebra (in the sense of Renault).
arxiv