Results 51 to 60 of about 172,451 (186)

Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells

Cell Reports, 2020
Summary: Germinal center (GC) B cells surge in their proliferative capacity, which poses a direct risk for B cell malignancies. G1- to S-phase transition is dependent on the expression and stability of D-type cyclins.
Parham Ramezani-Rad, Cindi Chen, Zilu Zhu, Robert C. Rickert   +3 more
doaj  

Identification of the gene encoding cyclin E1 (CCNE1) as a novel IGH translocation partner in t(14;19)(q32;q12) in diffuse large B-cell lymphoma

Haematologica, 2009
In a subset of B-cell malignancies, the genes encoding members of the cyclin D familiy are juxtaposed to immunoglobulin loci through recurrent chromosomal translocations.
Inga Nagel, Takashi Akasaka, Wolfram Klapper, Stefan Gesk, Sebastian Böttcher, Matthias Ritgen, Lana Harder, Michael Kneba, Martin J.S. Dyer, Reiner Siebert   +9 more
doaj   +1 more source

A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription

Oncogenesis
The essential G1-cyclin, CCND1, is frequently overexpressed in cancer, contributing to tumorigenesis by driving cell-cycle progression. D-type cyclins are rate-limiting regulators of G1-S progression in mammalian cells via their ability to bind and ...
Xuanmao Jiao, Gabriele Di Sante, Mathew C. Casimiro, Agnes Tantos, Anthony W. Ashton, Zhiping Li, Yen Quach, Dharmendra Bhargava, Agnese Di Rocco, Claudia Pupo, Marco Crosariol, Tamas Lazar, Peter Tompa, Chenguang Wang, Zuoren Yu, Zhao Zhang, Kawthar Aldaaysi, Ratna Vadlamudi, Monica Mann, Emmanuel Skordalakes, Andrew Kossenkov, Yanming Du, Richard G. Pestell   +22 more
doaj   +1 more source

Cell cycle regulation by the Wee1 Inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line

BMC Cancer, 2006
Background Wee1 kinase plays a critical role in maintaining G2 arrest through its inhibitory phosphorylation of cdc2. In previous reports, a pyridopyrimidine molecule PD0166285 was identified to inhibit Wee1 activity at nanomolar concentrations.
Sakamoto Masaharu, Selvendiran Karuppaiyah, Nakamura Toru, Torimura Takuji, Shinkawa Masako, Hashimoto Osamu, Koga Hironori, Ueno Takato, Sata Michio   +8 more
doaj   +1 more source

PTEN, a general negative regulator of cyclin D expression [PDF]

Cell Research, 2007
The tumor-suppressor phosphatase with tensin homology (PTEN) is frequently mutated in many malignancies and is one of the most well studied tumor suppressor genes 1, 2. PTEN, a lipid and protein dual phosphatase, plays a vital role in embryonic development, cell growth, apoptosis and cell migration.
Ye-Guang Chen, Lirong Diao
openaire   +3 more sources

The type I ribosome-inactivating protein α-MMC induced significant apoptosis of lung cancer A549 and 95-D cells by activating the caspase cascade through TNF signaling pathway

Frontiers in Pharmacology
Background:Ribosome-inactivating proteins (RIPs) are a class of toxic proteins with RNA N-glycosidase activity, primarily found in plants. Due to their antiviral, antibacterial and anti-tumor biological activities, RIPs have received extensive attention ...
Di Yang, Di Peng, Houke Li, Di Jia, Yiping Zhou, Bintao Hu, Wei Chen, Yao Meng   +7 more
doaj   +1 more source

Strategic cell-cycle regulatory features that provide mammalian cells with tunable G1 length and reversible G1 arrest.

PLoS ONE, 2012
Transitions between consecutive phases of the eukaryotic cell cycle are driven by the catalytic activity of selected sets of cyclin-dependent kinases (Cdks).
Benjamin Pfeuty
doaj   +1 more source

Lack of cyclin D3 induces skeletal muscle fiber-type shifting, increased endurance performance and hypermetabolism

Scientific Reports, 2018
The mitogen-induced D-type cyclins (D1, D2 and D3) are regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6 that drive progression through the G1 phase of the cell cycle.
Silvia Giannattasio, Giacomo Giacovazzo, Agnese Bonato, Carla Caruso, Siro Luvisetto, Roberto Coccurello, Maurizia Caruso   +6 more
doaj   +1 more source

Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells

Neural Development, 2009
Background Maintaining the correct balance of proliferation versus differentiation in retinal progenitor cells (RPCs) is essential for proper development of the retina.
Choi Yoon, Das Gaurav, Sicinski Piotr, Levine Edward M   +3 more
doaj   +1 more source

Selective cyclin-dependent kinase 4/6 inhibitors as anticancer drugs: Moving beyond hormone receptor-positive breast cancer

Indian Journal of Medical and Paediatric Oncology, 2019
The cyclin D-cyclin-dependent kinase (CDK) 4/6 pathway controls the cell cycle machinery by regulating the G1-to-S-phase transition. Dysregulation of this pathway, resulting in increased cellular proliferation, is frequently observed in a variety of ...
Tamojit Chaudhuri, K Govind Babu, K C Lakshmaiah, Lokanatha Dasappa, Linu Abraham Jacob, M C Suresh Babu, A H Rudresha, K N Lokesh, L K Rajeev   +8 more
doaj   +1 more source