Results 61 to 70 of about 584,094 (211)

Cell cycle regulation by the Wee1 Inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line [PDF]

, 2006
BACKGROUND: Wee1 kinase plays a critical role in maintaining G2 arrest through its inhibitory phosphorylation of cdc2. In previous reports, a pyridopyrimidine molecule PD0166285 was identified to inhibit Wee1 activity at nanomolar concentrations. This G2
A Blangy, A Kumar, AF Palazzo, AJ Ridley, C Murga, CF Welsh, CH McGowan, CJ Sherr, del Pozo MA, F Liu, Hironori Koga, J Guan, J Li, JA Ubersax, JJ Smith, JJ Smith, K Burridge, K Page, K Roovers, K Roovers, Karuppaiyah Selvendiran, L Connell-Crowley, LL Parker, M J.O’Connell, MA del Pozo, MA Schwartz, Masaharu Sakamoto, Masako Shinkawa, Michio Sata, MN Boddy, N Watanabe, O Hashimoto, OA Mizenina, Osamu Hashimoto, P Nurse, P Nurse, P Russell, RAL Sia, RY Poon, S Etienne-Manneville, SM Keenan, T Gonza'lez, T Kawabe, T Nakamura, Takato Ueno, Takuji Torimura, Toru Nakamura, V Baldin, WM Michael, Y Wang   +49 more
core   +3 more sources

Cyclin D1 and D3 expression in melanocytic skin lesions [PDF]

, 2010
Cyclins, cyclin-dependent kinases, as well as proteins cooperating with them are responsible for cell cycle regulation which is crucial for normal development, injury repair, and tumorigenesis.
A Gerger, Alicja Furgał-Borzych, Ana Alekseenko, Anna Wojas-Pelc, BC Sá de, C Ewanowich, C Stefanaki, ES Bales, G Annessi, G Argenziano, G Argenziano, Grzegorz J. Lis, Grzegorz Surówka, I Zalaudek, J Georgieva, JA Ramirez, Jan A. Litwin, JM Tripp, K Jørgensen, K Weserhoff, L Kuźbicki, LS Spofford, M Alaibac, M Kiess, ME Celebi, P Carli, R Hofmann-Wellenhof, RH Johr, RJ Friedman, SB Liang, TA Tran, VA Flørenes   +31 more
core   +3 more sources

Cell Cycling Models of Carcinogenesis: A Complex Systems Analysis [PDF]

arXiv, 2004
A new approach to the modular, complex systems analysis of nonlinear dynamics in cell cycling network transformations involved in carcinogenesis is proposed. Carcinogenesis is a complex process that involves dynamically inter-connected biomolecules in the intercellular, membrane, cytosolic, nuclear and nucleolar compartments that form numerous inter ...
arxiv  

Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells [PDF]

, 2009
Background Maintaining the correct balance of proliferation versus differentiation in retinal progenitor cells (RPCs) is essential for proper development of the retina.
Choi, Yoon, Das, Gaurav, Levine, Edward M, Sicinski, Piotr   +3 more
core   +4 more sources

PTEN, a general negative regulator of cyclin D expression [PDF]

Cell Research, 2007
The tumor-suppressor phosphatase with tensin homology (PTEN) is frequently mutated in many malignancies and is one of the most well studied tumor suppressor genes 1, 2. PTEN, a lipid and protein dual phosphatase, plays a vital role in embryonic development, cell growth, apoptosis and cell migration.
Ye-Guang Chen, Lirong Diao
openaire   +3 more sources

Tumor suppressor and anti-inflammatory protein: an expanded view on insulin-degrading enzyme (IDE) [PDF]

arXiv, 2008
In 1994, I conjectured that insulin-degrading enzyme (IDE) acts as an inhibitor of malignant transformation by degrading insulin and thus preventing this major growth-stimulatory hormone from binding and thereby inactivating the retinoblastoma tumor suppressor protein (RB).
arxiv  

Expression of cyclin D1, D3, E, and p27 in human renal cell carcinoma analysed by tissue microarray [PDF]

, 2003
Aberrations in the GI/S transition of the cell cycle have been observed in many malignancies and seem to be critical in the transformation process. Few studies have delineated the presence of GI/S regulatory defects and their clinical relevance in renal ...
B Ljungberg, B Ljungberg, C Gillett, CF Hwang, CJ Sherr, DG Skinner, DJ Demetrick, E Lees, F Hommura, G Kovacs, G Landberg, G Roos, H Moch, J Bartkova, J Kononen, JA McKay, JA Åkervall, JC Presti Jr, JW Harbour, K Keyomarsi, LH Sobin, NH Nielsen, NH Nielsen, OP Kallioniemi, P Larsson, RL Camp, S Aaltomaa, S Gansauge, S Kawauchi, S Lai, SI Reed, T Inaba, WC Hahn, Y Hedberg, Y Hedberg, Y Hedberg, Y Hedberg   +36 more
core   +2 more sources

Certain amplified genomic-DNA fragments (AGFs) may be involved in cell cycle progression and chloroquine is found to induce the production of cell-cycle-associated AGFs (CAGFs) in Plasmodium falciparum [PDF]

arXiv, 2015
It is well known that cyclins are a family of proteins that control cell-cycle progression by activating cyclin-dependent kinase. Based on our experimental results, we propose here a novel hypothesis that certain amplified genomic-DNA fragments (AGFs) may also be required for the cell cycle progression of eukaryotic cells and thus can be named as cell ...
arxiv  

Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development [PDF]

, 2012
We have previously demonstrated that ras-mediated skin tumorigenesis depends on signaling pathways that act preferentially through cyclin D1 and D2. Interestingly, the expression of cyclin D3 inhibits skin tumor development, an observation that conflicts
Kim, Yongbaek, Miliani De Marval, Paula L., Rodriguez-Puebla, Marcelo L., Sistrunk, Christopher, Wang, Xian   +4 more
core   +2 more sources

The cycline subalgebra of a Kumjian-Pask algebra [PDF]

Proc. Amer. Math. Soc. 145 (2017), no. 5, 1969-1980, 2016
Let $\Lambda$ be a row-finite higher-rank graph with no sources. We identify a maximal commutative subalgebra $\mathcal{M}$ inside the Kumjian-Pask algebra ${\rm KP}_R(\Lambda)$. We also prove a generalized Cuntz-Krieger uniqueness theorem for Kumjian-Pask algebras which says that a representation of ${\rm KP}_R(\Lambda)$ is injective if and only if it
arxiv