Results 71 to 80 of about 592,070 (354)

The HTLV-1 Tax protein binding domain of cyclin-dependent kinase 4 (CDK4) includes the regulatory PSTAIRE helix

Retrovirology, 2005
Background The Tax oncoprotein of human T-cell leukemia virus type 1 (HTLV-1) is leukemogenic in transgenic mice and induces permanent T-cell growth in vitro.
Grassmann Ralph, Müller Birthe, Fraedrich Kirsten   +2 more
doaj   +1 more source

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
International ...
Burdon, Tom, Savatier, Pierre, Smith, Austin   +2 more
core   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

CDK-independent activities of D type cyclins [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1999
D type cyclins are major downstream targets of extracellular signaling pathways which act to transduce mitogenic signals to the cell cycle machinery. Transcriptional induction of D type cyclins occurs in response to a wide variety of mitogenic stimuli, including the Ras signaling cascade [1,2] and the APC-L-catenin-Tcf/Lef pathway [3].
openaire   +3 more sources

Mouse Development and Cell Proliferation in the Absence of D-Cyclins [PDF]

Cell, 2004
D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. We tested the requirement for D-cyclins in mouse development and in proliferation by generating mice lacking all D-cyclins. We found that these cyclin D1(-/-)D2(-/-)D3(-/-) mice develop until mid/late gestation and die due
Kozar, K, Ciemerych, M A, Rebel, V I, Shigematsu, H, Zagozdzon, A, Sicinska, E, Geng, Y, Yu, Q, Bhattacharya, S, Bronson, R T, Akashi, K, Sicinski, P   +11 more
openaire   +5 more sources

JNK Inactivation Induces Polyploidy and Drug-Resistance in Coronarin D-Treated Osteosarcoma Cells

Molecules, 2018
Inhibition of proliferating cells is a critical strategy for cancer therapy. In this study, we demonstrated that coronarin D, a natural component extracted from the rhizomes of Hedychium coronarium, significantly suppressed the proliferation of ...
Chang-Te Hsu, Yi-Fu Huang, Chen-Pu Hsieh, Chia-Chieh Wu, Tai-Shan Shen   +4 more
doaj   +1 more source

Bifurcation analysis of a model of the budding yeast cell cycle [PDF]

, 2004
We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae. We show that Clb2-dependent kinase exhibits bistability (stable steady states of high or low kinase activity).
arxiv   +1 more source

Investigation of the impact of PTMs on the protein backbone conformation [PDF]

Amino Acids, Springer Verlag, 2019, 51 (7), pp.1065-1079, 2019
Post-Translational Modifications (PTMs) are known to play a critical role in the regulation of the protein functions. Their impact on protein structures, and their link to disorder regions have already been spotted on the past decade. Nonetheless, the high diversity of PTMs types, and the multiple schemes of protein modifications (multiple PTMs, of ...
arxiv   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source