Results 81 to 90 of about 592,070 (354)

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4 [PDF]

Genes & Development, 1993
The product (pRb) of the retinoblastoma gene (RB-1) prevents S-phase entry during the cell cycle, and inactivation of this growth-suppressive function is presumed to result from pRb hyperphosphorylation during late G1 phase. Complexes of the cyclin-dependent kinase, cdk4, and each of three different D-type cyclins, assembled in insect Sf9 cells ...
Scott W. Hiebert, Jun-ya Kato, Mark E. Ewen, Charles J. Sherr, Hitoshi Matsushime   +4 more
openaire   +2 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Immunohistochemical expression of cyclin D1 in invasive breast carcinoma and its correlation with clinicopathological parameters

Indian Journal of Pathology and Microbiology, 2020
Introduction: Breast cancer (BC) is the most common cancer and leading cause of death in women. Aim: This study was conducted to study the cyclin D1 expression in BC and its correlation with other clinicopathological parameters such as tumor size ...
Pranoti Vitthalrao Lengare, Siddhi Gaurish Sinai Khandeparkar, Avinash R Joshi, Bageshri P Gogate, Smita Ganeshrao Solanke, Sujit Hanumant Gore   +5 more
doaj   +1 more source

Analysis of strong decays of the charmed mesons D(2550), D(2600), D(2750) and D(2760) [PDF]

Phys.Rev.D83:014009,2011, 2010
In this article, we study the strong decays of the newly observed charmed mesons $D(2550)$, $D(2600)$, $D(2750)$ and $D(2760)$ with the heavy quark effective theory in the leading order approximation, and tentatively identify the $(D(2550),D(2600))$ as the $2S$ doublet $(0^-,1^-)$ and the $(D(2750),D(2760))$ as the $1D$ doublet $(2^-,3 ...
arxiv   +1 more source

Defining the residues governing the mitotic destruction of Drosophila cyclin A [PDF]

, 2007
Mitotic destruction of cyclin A has remained enigmatic ever since it was discovered. Regulation of cyclin A proteolysis appears to be different from that of other mitotic cyclins in diverse species.
Ramachandran, Vimal
core  

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Fbxo7 Gets Proactive with Cyclin D/cdk6 [PDF]

Cell Cycle, 2006
Although all three D cyclins bind and activate cdks 2, 4 and 6, Fbxo7 has been characterised as a selective enhancer of cdk6 activity. It increases activation by directly facilitating cdk6 interaction with viral and cellular D cyclins. Fbxo7 overexpression has transforming activity in murine fibroblasts, and it is also highly expressed in human cancers,
openaire   +2 more sources

Identification of Arabidopsis meiotic cyclins reveals functional diversification among plant cyclin genes.

PLoS Genetics, 2013
Meiosis is a modified cell division in which a single S-phase is followed by two rounds of chromosome segregation resulting in the production of haploid gametes.
Petra Bulankova, Svetlana Akimcheva, Nicole Fellner, Karel Riha   +3 more
doaj   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Identification of the gene encoding cyclin E1 (CCNE1) as a novel IGH translocation partner in t(14;19)(q32;q12) in diffuse large B-cell lymphoma

Haematologica, 2009
In a subset of B-cell malignancies, the genes encoding members of the cyclin D familiy are juxtaposed to immunoglobulin loci through recurrent chromosomal translocations.
Inga Nagel, Takashi Akasaka, Wolfram Klapper, Stefan Gesk, Sebastian Böttcher, Matthias Ritgen, Lana Harder, Michael Kneba, Martin J.S. Dyer, Reiner Siebert   +9 more
doaj   +1 more source