Results 191 to 200 of about 96,425 (243)

Protein Kinase C Regulates Meiosis in Mammalian Oocytes

open access: yesBioEssays, Volume 48, Issue 1, January 2026.
Protein kinase C (PKC) participates in the regulation of mammalian oocyte meiosis. PKC is involved in meiosis resumption in prophase I and in the stabilization of meiosis I and meiosis II spindles. PKC stimulates the maturation‐promoting factor during fertilization and stabilizes the mitotic spindle during early embryo development. ABSTRACT The protein
Jaroslav Kalous   +2 more
wiley   +1 more source

Mechanistic Insights and Therapeutic Potential of Small Nucleolar RNA Host Genes in the Carcinogenesis of Hepatocellular Carcinoma

open access: yesCancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo   +2 more
wiley   +1 more source

Niclosamide: CRL4<sup>AMBRA1</sup> mediated degradation of cyclin D1 following mitochondrial membrane depolarization. [PDF]

open access: yesRSC Med Chem
Coomar S   +7 more
europepmc   +1 more source

Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment

open access: yesCancer Medicine, Volume 15, Issue 1, January 2026.
Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang   +5 more
wiley   +1 more source

Inhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial Cells. [PDF]

open access: yesInvest Ophthalmol Vis Sci
Liu Q   +10 more
europepmc   +1 more source

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

open access: yesChemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha   +4 more
wiley   +1 more source

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