Results 241 to 250 of about 152,964 (318)

STOX1 Isoform A Promotes Proliferation and Progression of Hepatocellular Carcinoma by Dual Mechanisms of Transcriptionally Upregulation of Cyclin B1 and Activation of ROS‐Dependent PTEN/AKT1 Signaling

open access: yesCancer Medicine, Volume 14, Issue 13, July 2025.
ABSTRACT Background Dysregulation of transcription factors is one of the most common factors for the pathogenesis of hepatocellular carcinoma (HCC). To the best of our knowledge, no study has yet investigated the clinical significance and functional role of STOX1 in HCC. Methods Real‐time PCR, Western blotting and immunohistochemistry were performed to
Chunlin Jiang   +17 more
wiley   +1 more source

Immunohistochemical Analysis of Cyclin D1 Shows Deregulated Expression in Multiple Myeloma with the t(11;14) [PDF]

open access: green, 2000
Giancarlo Pruneri   +11 more
openalex   +1 more source

The role of cyclin D1 in lymphopoiesis

open access: yes, 2012
D Cyclins play an essential role connecting exogenous stimulation to the intrinsic cell cycle machinery. This family of proteins is composed of three members sharing a highly homologous domain, the cyclin box (coded by exons 1-3), which is responsible for their redundant role in the phosphorylation of the retinoblastoma protein upon association with ...
openaire   +1 more source

Exploring the Relationship Between Adipocytokines and Endometrial Cancer: Identifying Correlations With Clinico‐Pathological Prognostic Factors

open access: yesCancer Medicine, Volume 14, Issue 13, July 2025.
Endometrial cancer is linked to obesity and chronic inflammation, potentially mediated by adipocytokines like adiponectin, leptin, IL6, and TNFα. This study examined mRNA expression of these markers and their receptors in cancerous versus benign endometrial tissue using qRT‐PCR.
Irene Ray   +9 more
wiley   +1 more source

The Role of Iron Chelation Therapy in Colorectal Cancer: A Systematic Review on Its Mechanisms and Therapeutic Potential

open access: yesCancer Medicine, Volume 14, Issue 13, July 2025.
Iron chelation is a promising yet underexplored strategy for colorectal cancer (CRC) treatment. Iron chelators have a dual role in inhibiting and potentially promoting cancer progression. Iron chelation affects key CRC pathways, including histone methylation, NDRG1 upregulation, Wnt/β‐catenin, and p53 modulation.
Gihani Vidanapathirana   +4 more
wiley   +1 more source

A potential mechanism for fumonisin B1-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3β activity [PDF]

open access: bronze, 2000
Danica Ramljak   +8 more
openalex   +1 more source

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