Results 251 to 260 of about 152,964 (318)

Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
IL‐11 drives tumour progression and is linked to poor survival in lung adenocarcinoma patients, as well as an immunosuppressive tumour microenvironment. Antibody targeting of the IL‐11 receptor (IL‐11RA) shows significant anti‐tumour effects in a patient‐derived xenograft model highlighting IL‐11 as a compelling therapeutic target.
Cristina Cirauqui, Laura Ojeda, Itziar Otano, Irene Pazos, Alba Santos, Eva M. Garrido‐Martín, Patricia Yagüe, Javier Ramos‐Paradas, Sonia Molina‐Pinelo, Giovanna Roncador, José Luis Solórzano, M. Teresa Muñoz, Patricia Cozar, Patricia Plaza, Rocío Suárez, Marta Jiménez, Roberto Moreno, Arantxa Rosado, Pablo Gámez, Ricardo García‐Luján, Jon Zugazagoitia, E. Alejandro Sweet‐Cordero, Mariano Barbacid, Amancio Carnero, Irene Ferrer, Luis Paz‐Ares   +25 more
wiley   +1 more source

Scoparone suppresses proliferation and cell cycle of hepatocellular carcinoma cells via inhibiting AKT/GSK-3β/cyclin D1 signaling pathway. [PDF]

Transl Cancer Res
Hong M, Zhu H, Liu W, Zhang P, Yu S, Gao Q, Shen G, Li B, Wang G.   +8 more
europepmc   +1 more source

Mushroom Bioactive Molecules as Anticancerous Agents: An Overview

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
This review discusses the molecular mechanisms through which these compounds inhibit cancer progression, including the induction of reactive oxygen species, inhibition of mitotic kinase and angiogenesis, and suppression of topoisomerase activity. By providing the latest insights on these anti‐tumor agents and their pharmacological actions, our review ...
Ali Ikram, Nasir A. Ibrahim, Muhammad Tayyab Arshad, Abroo Fatima, Ali Asghar Taseer, Mahreen Faqeer Hussain, Zunair Abdullah, Nosiba S. Basher, Muhammed Adem Abdullahi, Ammar AL‐Farga, Mohammed Ali Al‐Duais   +10 more
wiley   +1 more source

SHP2 inhibition and adjuvant therapy synergistically target KIT-mutant GISTs via ERK1/2-regulated GSK3β/cyclin D1 pathway. [PDF]

Clin Transl Med
He C, Yu J, Mao S, Yang S, Jiang X, Huang L, Li M, He Y, Zhang X, Xiang X.   +9 more
europepmc   +1 more source

A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
This review highlights the molecular mechanism by which lycopene imparts its anticancerous role, focusing on clinical and animal trials to validate its effectiveness. The antioxidant profile of lycopene promotes anticancerous properties that reduce cancer prevalence by activating cell signaling pathways and gene expression (involved in cancer cell ...
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Usman Khalid, Hassan Raza, Muhammad Imran, Muzzamal Hussain, Waleed Al Abdulmonem, Suliman A. Alsagaby, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Muhammad Asif Khan, Tadesse Fenta Yehuala, Samy Selim, Ehab M. Mostafa   +13 more
wiley   +1 more source

Expression of Cyclin D1 and Claudin-1 in Invasive Breast Carcinoma and Their Correlation with Clinicopathological Parameters. [PDF]

Iran J Pathol
Sehrawat R, Dhawan V, Roy M, Kediya A, Nijhawan VS.   +4 more
europepmc   +1 more source

TP53‐Mutated Acute Myeloid Leukemia: Unanswered Questions

Hematological Oncology, Volume 43, Issue 4, July 2025.
ABSTRACT TP53‐mutated acute myeloid leukemia (AML) remains one of the most treatment‐resistant hematologic malignancies, with poor overall survival despite advancements in therapeutic strategies. The loss of functional p53 compromises DNA repair, apoptosis, and genomic stability, rendering both conventional and novel therapies largely ineffective. This
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Caterina Labanca, Giulio Caridà, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Noemi Puccio, Antonino Neri, Fortunato Morabito, Massimo Gentile   +11 more
wiley   +1 more source

Clinical significance of Cyclin D1 by complete quantification detection in mantle cell lymphoma: positive indicator in prognosis. [PDF]

Diagn Pathol
Yang Y, Song L, Yin Y, Gao Y, Wang Y, Wu S, Wang J, Pan Y, Sui X, Jiang L, Zhang Y, Yu G.   +11 more
europepmc   +1 more source

Caveolin‐1 Regulates Parathyroid Hormone (PTH)‐Related Protein (PTHrP) Actions on PTH Receptor Type 1 in Bone Cells

Journal of Cellular Physiology, Volume 240, Issue 7, July 2025.
Caveolin1 interacts with PTH1R at membrane‐bound microdomains delaying receptor internalization, promoting cAMP signaling over calcium and ERK1/2 kinase pathways, and regulating bone formation and bone remodeling gene expression upon agonist stimulation in osteoblastic cells.
Sara Heredero‐Jiménez, Eduardo Martín‐Guerrero, Joan Pizarro‐Gómez, Irene Tirado‐Cabrera, Luis Álvarez‐Carrión, Teresita Bellido, Arancha R. Gortázar, Juan A. Ardura   +7 more
wiley   +1 more source

Increased SOX10, p16, and Cyclin D1 Immunoreactivity Differentiates MAP Kinase-activated Low-grade Gliomas From Piloid Gliosis. [PDF]

Am J Surg Pathol
Tang V, Zhang KY, Mirchia K, Lu R, Guney E, Terry M, Ligon AH, Ligon KL, Eberhart CG, Perry A, Lucas CG.   +10 more
europepmc   +1 more source