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Cyclin D1 as a target for chemoprevention
Lung Cancer, 2003Lung cancer is the leading cause of cancer mortality. Chemoprevention is an attractive strategy to combat this major public health problem. Pre-clinical and clinical studies have identified diverse candidate chemopreventive agents that affect cellular proliferation, differentiation, apoptosis and tumor angiogenesis, among other pathways.
W Jeffrey, Petty +2 more
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Cyclin D1 Immunoreactivity in Meningiomas
Cellular and Molecular Neurobiology, 2008Cyclin D1 is an important nuclear protein required for progression of cells through the G1 phase of the cell cycle. The proliferative potential of meningiomas has been studied using various proliferative markers. However, there have been only few published studies evaluating Cyclin D1 immunoreactivity in meningiomas.The aim of our study was to analyze ...
Sanja, Milenković +5 more
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Cyclin D1 in mammary carcinoma
The Journal of Pathology, 1997The control of the cell-cycle-associated protein cyclin D1 and its variable behaviour in normal and transformed cells is described and contrasted with its activity in vivo. The role of cyclin D1 as a prognostic and predictive marker is examined in clinical breast cancer.
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The activities of cyclin D1 that drive tumorigenesis
Trends in Molecular Medicine, 2004The proto-oncogene cyclin D1 has been implicated in the genesis of a large proportion of human tumors from diverse histological origins. It has long been assumed that the action of cyclin D1, as an activator of cdk4 and cdk6 and leading to progression through the G1 phase of the cell cycle, underlies its pathological activity.
Mark E, Ewen, Justin, Lamb
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Cyclin D1 overexpression in hepatocellular carcinoma
Liver, 2001Abstract: Background/Aims: Cyclin D1 gene amplification and cyclin D1 protein overexpression have been reported in various human tumors, including hepatocellular carcinoma (HCC). However, their significance is still controversial. In the present study, we examined the expression of cyclin D1 and its relationships to p53 and Ki‐67 in HCCs. Methods: The
M, Joo +4 more
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Cyclin D1 positive follicular lymphoma
Journal of Clinical Pathology, 2009This report describes an unusual case of cyclin D1 expression by an otherwise typical follicular lymphoma, of low histological grade. BCL2–IGH and CCND1–IGH fusions were identified by interphase fluorescence in situ hybridisation.
B, Olsen +4 more
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Cyclin D1 in Breast Cancer Pathogenesis
Journal of Clinical Oncology, 2005Taking a perspective on available evidence that emphasizes relevance to human disease, cyclin D1 is solidly established as an oncogene with an important pathogenetic role in breast cancer and other human tumors. However, the precise cellular mechanisms through which aberrant cyclin D1 expression drives human neoplasia are less well established. Indeed,
Andrew, Arnold, Alexandros, Papanikolaou
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Regulation of cyclin D1 gene expression
Biochemical Society Transactions, 2010Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. In different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas their disregulation can contribute to overexpression of cyclin D1 in tumorigenesis. Here, we discuss
Ini-Isabée, Witzel +2 more
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Implication of Cyclin D1 in Malignant Lymphoma
Critical Reviews™ in Oncogenesis, 1996The chromosomal translocation t(11;14)(q13;q32) is observed in a number of lymphoid malignancies but is specifically associated with a particular subtype of non-Hodgkin's lymphoma called mantle cell lymphoma, where it is observed in up to 70% of cases. This translocation juxtaposes IGH sequences at 14q32 to a region variously termed BCL1/PRAD1 at 11q13,
M, Callanan +3 more
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