Ral GTPases Contribute to Regulation of Cyclin D1 through Activation of NF-κB
, 2000 Dale O. Henry +6 more
openalex +1 more source
Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases
MedComm, Volume 6, Issue 7, July 2025.Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar +10 more
wiley +1 more source
Inhibition of Cyclin D1 by Novel Biguanide Derivative YB-004 Increases the Sensitivity of Bladder Cancer to Olaparib via Causing G0 / G1 Arrest. [PDF]
Int J Biol SciXiao D +7 more
europepmc +1 more source
MedComm, Volume 6, Issue 7, July 2025.FTO deficiency leads to an increase in m6A levels and a decrease in mRNA stability of KAT8. Subsequently, KAT8 depletion leads to heterochromatin loss and the subsequent aging by acetylating RSF1 at K1050. Overall, the FTO–KAT8–RSF1 axis is a new target for delaying skin aging.
Fan Wang +12 more
wiley +1 more source
MedComm, Volume 6, Issue 7, July 2025.Lactate, beyond a metabolic byproduct, regulates immunity and inflammation, linked to cardiovascular diseases (CVD) via metabolic reprogramming. Lactylation, a lactate‐driven epigenetic mark, modulates gene expression in fibrosis, lipid disorders, and CVD progression.
Mengyang Song +3 more
wiley +1 more source
Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets
MedComm, Volume 6, Issue 7, July 2025.Natural compounds modulate the TGF‐β pathway, which acts as both a tumor suppressor and promoter during cancer progression. Agents such as ginsenosides, halofuginone, and EGCG influence cell proliferation, apoptosis, and angiogenesis. These bioactive molecules may complement standard therapies, highlighting the need for advanced formulations ...
Reham Hassan Mekky +9 more
wiley +1 more source
Establishment of a human ovarian endometrioid carcinoma cell line by constitutive expression of cyclin-dependent kinase 4, cyclin D1 and telomerase reverse transcriptase. [PDF]
Hum CellHoshino H +10 more
europepmc +1 more source
Phosphate in Physiological and Pathological Mineralization: Important yet Often Unheeded
MedComm, Volume 6, Issue 7, July 2025.Phosphate serves as a building block for physiological mineralization, and as a signaling molecule that regulates the activity of mineralizing cells. The disturbance in these processes could induce a series of pathological mineralization, with abnormal mineralization of hard tissues and ectopic mineralization of soft tissues being the most ...
Wen Qin +8 more
wiley +1 more source
Cyclin D1-negative and SOX11-positive B-cell lymphoma with CD5 and CD10 coexpression and MYC rearrangement: A diagnostic challenge. [PDF]
EJHaemYan M, Zhang Y, Dogan A, Yabe M.
europepmc +1 more source
A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
Aging Cell, Volume 24, Issue 7, July 2025.This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante +24 more
wiley +1 more source