Results 261 to 270 of about 95,731 (301)

Cyclin dependent kinase regulation

Current Opinion in Cell Biology, 1995
Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and their activities are consequently tightly regulated. Recent developments in the field of CDK regulation have included the discovery and characterization of CDK inhibitors. These developments have had an impact on our understanding of how other signalling pathways may be linked to ...
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Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates

Nature, 2005
Cell-cycle events are controlled by cyclin-dependent kinases (CDKs), whose periodic activation is driven by cyclins. Different cyclins promote distinct cell-cycle events, but the molecular basis for these differences remains unclear. Here we compare the specificity of two budding yeast cyclins, the S-phase cyclin Clb5 and the M-phase cyclin Clb2, in ...
Mart, Loog, David O, Morgan
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Mitotic cyclins and cyclin-dependent kinases in melanocytic lesions

Human Pathology, 1998
Recent evidence has implicated cyclins and cyclin-dependent kinases in the evolution and progression of various malignancies. We studied the immunohistochemical expression of cyclin A, cyclin B, and cyclin-dependent kinase p34cdc2 in a broad spectrum of benign and malignant melanocytic lesions.
T A, Tran, J S, Ross, J A, Carlson, M C, Mihm   +3 more
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Inhibitors of cyclin-dependent kinase and cancer

Journal of Molecular Medicine, 1995
Recent research has yielded a dramatic increase in the number of connections between oncogenesis and the proteins which regulate the cell cycle. Three classes of protein which inhibit the activity of cyclin-dependent kinases (CDKs) have emerged as potential targets for oncogenic inactivation.
J R, Biggs, A S, Kraft
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Cyclins and Cyclin-Dependent Kinases: Theme and Variations

1995
Publisher Summary This chapter introduces cyclins and their partner—cyclin dependent kinases (CDKs)—and the ways in which CDK complexes can be regulated. Cyclins are intimately concerned with regulating and coordinating deoxyribonucleic acid (DNA) replication and cell division.
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Designing Inhibitors of Cyclin-Dependent Kinases

Annual Review of Pharmacology and Toxicology, 2002
Cyclin-dependent kinases (cdks) play a pivotal role in controlling progression through the cell cycle. The complex mechanisms that control cdks have been elucidated and, in the case of cdk2, explained with reference to X-ray crystal structures of the catalytically active and inactive kinase.
Ian R, Hardcastle, Bernard T, Golding, Roger J, Griffin   +2 more
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Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors

2023
Nathan H. Lents, Richard T. Piszczatowski   +1 more
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Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors: Detection Methods and Activity Measurements

2004
The cyclin/cyclin-dependent kinase (Cdk) complexes and the Cdk inhibitors (CDKI) are crucial regulators of cell cycle progression in all eukaryotic cells. Using rat cardiac myocytes as a model system, this chapter provides a detailed account of methods that can be employed to measure both cyclin/Cdk activity in cells and the extent of CDKI inhibitory ...
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Cyclin-Dependent Kinase Inhibition by Flavoalkaloids

Mini-Reviews in Medicinal Chemistry, 2012
Chromone alkaloids and flavoalkaloids are an important group of natural products possessing promising medicinal properties. A chromone alkaloid rohitukine is a major bioactive chemical constituent of plant Dysoxylum binectariferum (Meliaceae) Hook. which is phylogenetically related to the Ayurvedic plant, D. malabaricum Bedd.
S K, Jain, S B, Bharate, R A, Vishwakarma   +2 more
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Chemical inhibitors of cyclin-dependent kinases

Trends in Cell Biology, 1995
The eukaryotic cell division cycle is regulated by a family of protein kinases, the cyclin-dependent kinases (cdk's), constituted of at least two subunits, a catalytic subunit (cdk1-7) associated with a regulatory subunit (cyclin A-H). Transient activation of cdk's is responsible for transition through the different phases of the cell cycle.
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