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Ten quick tips for ensuring machine learning model validity. [PDF]

open access: yesPLoS Comput Biol
Goh WWB, Kabir MN, Yoo S, Wong L.
europepmc   +1 more source

Evaluation of HMGB1 as possible marker via breast organoid cultures research. [PDF]

open access: yesOncol Rep
Ciaramella V   +7 more
europepmc   +1 more source

High-throughput discovery and deep characterization of cyclin-CDK docking motifs

open access: yes
Örd M   +10 more
europepmc   +1 more source
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Cyclin E

The International Journal of Biochemistry & Cell Biology, 2004
E-type cyclins (cyclin E1 and cyclin E2) are expressed during the late G1 phase of the cell cycle until the end of the S-phase. The activity of cyclin E is limiting for the passage of cells through the restriction point "R" which marks a "point of no return" for cells entering the division cycle from a resting state or passing from G1 into S-phase ...
Tarik, Möröy, Christoph, Geisen
openaire   +2 more sources

Viral cyclins

Reviews in Medical Virology, 2000
Cyclins are regulatory subunits of the cyclin-dependent protein kinases (CDKs). Members of this serine-threonine kinase family regulate the progression of cells through the division cycle. Until some years ago, cyclins were presumed to be encoded exclusively by eukaryotic cells.
S, Mittnacht, C, Boshoff
openaire   +2 more sources

Cyclins, cyclin‐dependent kinases and differentiation

BioEssays, 1997
AbstractCyclin‐dependent kinases and their regulatory subunits, the cyclins, are known to regulate progression through the cell cycle. Yet these same proteins are often expressed in non‐cycling, differentiated cells. This review surveys the available information about cyclins and cyclin‐dependent kinases in differentiated cells and explores the ...
C Y, Gao, P S, Zelenka
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Viral encoded cyclins

Seminars in Cancer Biology, 1999
Cyclins are known effectors of cellular proliferation. While originally considered as the product of cellular genes, it is now clear that representatives of this class of proteins can be encoded by certain viruses. One of these viruses is HHV-8, a gamma herpesvirus implicated as a causative agent of Kaposi's Sarcoma and lymphomas in humans.
E, Cannell, S, Mittnacht
openaire   +2 more sources

Viral-encoded cyclins

Current Opinion in Genetics & Development, 2000
D-type cyclin homologs have been found in the genomes of herpesviruses associated with neoplasias. They appear to exploit features of G(1) cyclins but extend their properties to allow for deregulation of the cell cycle. Advances in the study of the molecular basis for these novel features as well as the potential role of viral cyclins in tumorigenesis ...
H, Laman, D J, Mann, N C, Jones
openaire   +2 more sources

Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors in the Mouse Nervous System

Molecular Neurobiology, 2020
Development and normal physiology of the nervous system require proliferation and differentiation of stem and progenitor cells in a strictly controlled manner. The number of cells generated depends on the type of cell division, the cell cycle length, and the fraction of cells that exit the cell cycle to become quiescent or differentiate. The underlying
Alice Grison, Suzana Atanasoski
openaire   +3 more sources

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