Results 91 to 100 of about 40,343 (298)

The Mitogen‐Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis‐Immunity Trade‐Off in Cotton by Regulating Salicylic Acid Biosynthesis

Advanced Science, EarlyView.
AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia, Jingshang Wen, Jihang Li, Meina Feng, Yiming He, Ruojun Liu, Qian Liu, Junli Zhang, Kai Cheng, Xiangyu Zhang, Xiao Zhang   +10 more
wiley   +1 more source

Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells [PDF]

, 2006
Cyclin protein behavior has not been systematically investigated in multinucleated cells with asynchronous mitoses. Cyclins are canonical oscillating cell cycle proteins, but it is unclear how fluctuating protein gradients can be established in ...
Philippsen, Peter, Gladfelter, Amy S, Gladfelter, A. S., Hungerbuehler, A. Katrin, Hungerbuehler, A. K., Philippsen, P., Gladfelter, Amy S., Gladfelter AS, Hungerbuehler AK, Philippsen P   +9 more
core   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Flowcytometric evaluation of cell cycle regulators (cyclins and cyclin dependent kinase inhibitors) expressed on bone marrow cells of patients with chronic myelogenous leukemia and multiple myeloma

Turkish Journal of Hematology, 2012
OBJECTIVE: Etiopathology of malignancy can be demonstrated by the comparison of the quantified changes in the different phases of the cycle about cyclins and cyclin dependent kinase inhibitors (CDKI) in healthy and malignant proliferated cells.
Selami Koçak Toprak, Klara Dalva, Merih Kızıl Çakar, Nazmiye Kurşun, Meral Beksaç   +4 more
doaj   +1 more source

Kinase-independent function of E-type cyclins in liver cancer

, 2018
Significance Amplification of the cyclin E genes and overexpression of cyclin E proteins is very frequent in several human tumor types. In particular, overexpression of E cyclins was implicated in the pathogenesis of liver cancers. According to
Ewa Sicinska, M. Emmanuelle Jecrois, Roderick T. Bronson, Wojciech Michowski, Yan Geng, Katharine E. Sweeney, Agnieszka Zagozdzon, Richard C. Han, Steven P. Gygi, Piotr Sicinski, Lijun Liu, Nan Ke, Joel M. Chick, Yaoyu E. Wang   +13 more
core   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Cyclin F Expression in Clear Cell Renal Cell Carcinoma and Its Effect on Biological Behavior of Renal Carcinoma Cell Lines

Zhongliu Fangzhi Yanjiu
ObjectiveTo investigate the expression of Cyclin F in clear cell renal cell carcinoma (ccRCC), its clinicopathological characteristics, and its effect on the biological behavior of renal cancer cell lines MethodsRT-qPCR and Western blot were used to ...
Min SU, Yan WANG, Jie HUA, Tianyun WANG, Shengnan XU, Xiang KUI   +5 more
doaj   +1 more source

Positive feedback in the activation of Gl cyclins in yeast

, 1991
International audienceYEAST cells become committed to the mitotic cell cycle at a stage during Gl called Start1. To enter Start, cells must grow to a critical size.
Léon Dirick, Kim Nasmyth, Dirick, Léon, Nasmyth, Kim   +3 more
core   +1 more source

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma

Annals of Agricultural and Environmental Medicine, 2015
[b]Introduction and objectives. [/b]Cyclin A, encoded by CCNA (cyclin A) gene with locus in chromosome 4q27, and cyclin B1, encoded by CCNB1 (cyclin B1) gene with locus in chromosome 5q12, are proteins that play a key role in the passage through the ...
Anna Cyniak-Magierska, Magdalena Stasiak, Maciej Naze, Marek Dedecjus, Jan Brzeziński, Andrzej Lewiński   +5 more
doaj   +1 more source