Results 91 to 100 of about 37,065 (297)
G1/S cyclins interact with regulatory subunit of PKA via A-kinase anchoring protein, AKAP95
, 2006 The mechanisms by which cyclins promote mammalian cell cycle progression have been a topic of intense investigation over the last decade. We previously described an interaction between D-type cyclins and A-kinase anchoring protein, AKAP95.
Jacques E. Dumont +9 more
core +1 more source
Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma
Annals of Agricultural and Environmental Medicine, 2015 [b]Introduction and objectives. [/b]Cyclin A, encoded by CCNA (cyclin A) gene with locus in chromosome 4q27, and cyclin B1, encoded by CCNB1 (cyclin B1) gene with locus in chromosome 5q12, are proteins that play a key role in the passage through the ...
Anna Cyniak-Magierska +5 more
doaj +1 more source
Advanced Science, EarlyView.PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu +12 more
wiley +1 more source
Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer
Cell Division, 2010 The highly conserved E-type cyclins are core components of the cell cycle machinery, facilitating the transition into S phase through activation of the cyclin dependent kinases, and assembly of pre-replication complexes on DNA.
Musgrove Elizabeth A, Caldon C
doaj +1 more source
Advanced Science, EarlyView.Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska +14 more
wiley +1 more source
Functional analysis of B1-type cyclins in Arabidopsis thaliana
, 2007 Cyclins play a vital role in controlling progress through the eukaryotic cell cycle. Specific cyclins are required at each cell cycle transition to activate their partner cyclin- dependent kinase. The focus of this study were the B1-type cyclins that are
Roodbarkelari, Farshad
core
D-type cyclins in Xenopus laevis [PDF]
, 1996 I have isolated two D-type cyclins and a putative kinase partner related to Cdk4 from the frog Xenopus laevis. Three D-type cyclins have previously been isolated from mammalian species, where they are thought to be involved in the control of cell ...
Cockerill, M.J.
core
G1 Phase Cyclins in Cancer Development and Progression
, 2009 Cyclin D1 and cyclin E are rate limiting for progression through G1 and entry into S phase during the cell cycle. Cyclin D1 plays a crucial role in linking favourable environmental conditions with cell cycle progression.
Alao, John Patrick,, John Patrick Alao
core +1 more source
Stem Cell Research, 2015 We have previously shown that pluripotent stem cells can be induced from adult somatic cells which were exposed to protein extracts isolated from mouse embryonic stem cells (mESC).
Yoo-Wook Kwon +6 more
doaj +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source