Results 71 to 80 of about 40,343 (298)

Cyclin K and cyclin D1b are oncogenic in myeloma cells [PDF]

Molecular Cancer, 2010
AbstractBackgroundAberrant expression of cyclin D1 is a common feature in multiple myeloma (MM) and always associated with mantle cell lymphoma (MCL).CCND1gene is alternatively spliced to produce two cyclin D1 mRNA isoforms which are translated in two proteins: cyclin D1a and cyclin D1b.
Marsaud, Véronique, Tchakarska, Guergana, Andrieux, Geoffroy, Liu, Jian-Miao, Dembele, Doulaye, Jost, Bernard, Wdzieczak-Bakala, Joanna, Renoir, Jack-Michel, Sola, Brigitte   +8 more
openaire   +3 more sources

Plasticity of mitotic cyclins in promoting the G2-M transition

Cyclins and cyclin-dependent kinases (CDKs) orchestrate key events in the cell cycle. However, the uniqueness of individual mitotic cyclins has been a long-standing puzzle. By rapidly removing cyclins in G2 human cells, we found that deficiency of B-type
Mak, Joyce P.Y., Poon, Randy Yat Choi, Ma, Hoi Tang, CRNCEC, Adrijana, YEUNG, Tsz Kwan, CHOI, Hon Fung, NG, Lau Yan, LAU, Ho Wai   +7 more
core   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Role of Kupffer Cells in Thioacetamide-Induced Cell Cycle Dysfunction

Molecules, 2011
It is well known that gadolinium chloride (GD) attenuates drug-induced hepatotoxicity by selectively inactivating Kupffer cells. In the present study the effect of GD in reference to cell cycle and postnecrotic liver regeneration induced by thioacetamide
Mirandeli Bautista, Jaime Esquivel-Soto, José Gutiérrez-Salinas, Jorge Alberto Mendoza-Pérez, Tomas Fregoso-Aguilar, Carmen Valadez-Vega, Eduardo Madrigal-Santillán, María Isabel Sánchez-Reus, José A. Morales-González, María Cascales, David Andres   +10 more
doaj   +1 more source

Dynamic expression profiles from static cytometry data: component fitting and conversion to relative, "same scale" values. [PDF]

PLoS ONE, 2012
Cytometry of asynchronous proliferating cell populations produces data with an extractable time-based feature embedded in the frequency of clustered, correlated events.
Jayant Avva, Michael C Weis, R Michael Sramkoski, Sree N Sreenath, James W Jacobberger   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Functional analysis of B1-type cyclins in Arabidopsis thaliana [PDF]

, 2007
Cyclins play a vital role in controlling progress through the eukaryotic cell cycle. Specific cyclins are required at each cell cycle transition to activate their partner cyclin- dependent kinase. The focus of this study were the B1-type cyclins that are
Roodbarkelari, Farshad
core  

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source