Results 81 to 90 of about 40,343 (298)
Promoter de-methylation of
Clinical Epigenetics, 2011 Sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, induces potent anti-proliferative effects in prostate cancer cells. One mechanism that may contribute to the anti-proliferative effects of SFN is the modulation of epigenetic ...
Hsu Anna +5 more
doaj +1 more source
Localization of Cyclins K and L in interphase.
, 2016 GFP-cyclin K and HA-cyclins L1 and L2 were expressed in HeLa cells and their localizations were analysed by fluorescence microscopy using respectively GFP-cyclin K (A) or immunofluorescence with anti-cyclin L1 (D) and L2 (G) antibodies.
Marie-Line Escande (47791) +3 more
core +1 more source
Advanced Science, EarlyView.Natural variation in the maize ZmASB1 promoter regulates tryptophan accumulation, root development, and drought tolerance through a tryptophan–auxin pathway. A 5‐bp InDel alters ZmDOF17 binding and promoter activity, and the favorable allele is enriched during breeding. These findings reveal a cis‐regulatory mechanism linking amino acid metabolism with
Xiaoyi Yang +17 more
wiley +1 more source
Cancer Management and Research, 2020 Li-Wei Shi,1,2 Zhi-Bo Zhao,3 Li Zhong,1 Jian Gao,1 Jian-Ping Gong,3 Hang Chen,4 Yu Min,4 Yi-Yin Zhang,5 Zhi Li4 1Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of ...
Shi LW +8 more
doaj
Asynchronous nuclear division cycles in multinucleated cells [PDF]
, 2006 Synchronous mitosis is common in multinucleated cells. We analyzed a unique asynchronous nuclear division cycle in a multinucleated filamentous fungus, Ashbya gossypii.
Peter Philippsen +8 more
core +1 more source
Advanced Science, EarlyView.An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng +9 more
wiley +1 more source
Saccharomyces cerevisiae cell cycle: cdc28 and the G1 cyclins
, 1991 Two families of cyclin-like proteins have been found in S. cerevisiae. The clb proteins are the mitotic cyclins. The cln proteins provide an essential function, are required for the G1/S transition, and appear to be rate-limiting for START, but have no ...
Futcher, A. B.
core
Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast
, 1991 International audienceWe have isolated a number of cDNAs derived from human mRNAs that are able to substitute for G1 cyclin genes in S. cerevisiae. Several of these encode human cyclins A, B1, and B2. Three novel genes have been identified, which we call
Dulic, Vjekoslav +2 more
core +1 more source
Advanced Science, EarlyView.Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu +18 more
wiley +1 more source
Expression of D-type cyclins in differentiating cells of the mouse spinal cord
Genetics and Molecular Biology, 2007 The D-type cyclins form complexes with the cyclin dependent (CD) kinases CDK4 and CDK6 and promote the G1-S phase transition of the cell cycle by antagonizing the retinoblastoma suppresser protein pRB. In the developing nervous system D-type cyclins show
Patricy de Andrade Salles +3 more
doaj +1 more source