Results 111 to 120 of about 40,343 (298)
Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
A mei-P26 is required for initiation of meiosis in the Drosophila male germline
Cell Structure and FunctionMei-P26, a member of the TRIM-NHL family, plays a pivotal role in Drosophila germline development, including female meiosis. However, its role in male meiosis remains unclear.
Mai Oda, Yuri Tanaka, Yoshihiro H. Inoue
doaj +1 more source
Cyclins of phases G1, S and G2/M are overexpressed in aneuploidy mammary carcinomas
, 2000 Expression of cyclins A, B1 and D1 in human breast cancer was analyzed using dual-parameter flow cytometry with simultaneous evaluation of the DNA content.
ROCCHETTA, M +16 more
core +1 more source
Advanced Science, EarlyView.Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo +11 more
wiley +1 more source
Chatterboxes: the structural and functional diversity of cyclins
Proteins of the cyclin family have divergent sequences and execute diverse roles within the cell while sharing a common fold: the cyclin box domain.
Tatum NJ, Endicott JA
core +2 more sources
Lactucin inhibits growth and induces apoptosis in gastric cancer cells by targeting MAPK signaling
Folia Histochemica et CytobiologicaINTRODUCTION: Lactucin, a sesquiterpene lactone isolated from chicory (Cichorium intybus L.), demonstrates broad-spectrum anticancer activity across multiple malignancies, yet its mechanistic role in gastric cancer (GC) remains unexplored.
Dan Wei, Peng-Li Wang, Jing Jiang
doaj +1 more source
A roller coaster ride with the mitotic cyclins
, 2005 Cyclins are discovered as proteins that accumulate progressively through interphase and disappear abruptly at mitosis during each cell cycle. In mammalian cells, cyclin A accumulates from late G1 phase and is destroyed before metaphase, and cyclin B is ...
Poon, Randy Y.C. +2 more
core +1 more source
TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
Advanced Science, EarlyView.TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source
PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling
Advanced Science, EarlyView.PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu +13 more
wiley +1 more source