Results 131 to 140 of about 141,408 (359)

PCSK9 Promotes the Malignancy of Triple‐negative Breast Cancer Cells by Reducing Cholesterol Levels at the Plasma Membrane to Activate EGFR and HER3

Advanced Science, EarlyView.
By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley   +1 more source

Complex Systems Analysis of Cell Cycling Models in Carcinogenesis [PDF]

arXiv, 2004
Carcinogenesis is a complex process that involves dynamically inter-connected modular sub-networks that evolve under the influence of micro-environmentally induced perturbations, in non-random, pseudo-Markov chain processes. An appropriate n-stage model of carcinogenesis involves therefore n-valued Logic treatments of nonlinear dynamic transformations ...
arxiv  

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

Genes & Development, 1993
A two-hybrid protein interaction screen was used to isolate cDNAs encoding human proteins that can interact with human CDK2 in yeast. A new member of the retinoblastoma susceptibility gene family, Rbr-2 (Rb-related), was obtained. The sequence of the Rbr-
G. Hannon, D. Demetrick, D. Beach
semanticscholar   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment

Cell Reports, 2020
Summary: Recurrent copy-number alterations, mutations, and transcript fusions of the genes encoding CDKs/cyclins are characterized in >10,000 tumors. Genomic alterations of CDKs/cyclins are dominantly driven by copy number aberrations.
Weiwei Shan, Jiao Yuan, Zhongyi Hu, Junjie Jiang, Yueying Wang, Nicki Loo, Lingling Fan, Zhaoqing Tang, Tianli Zhang, Mu Xu, Yutian Pan, Jiaqi Lu, Meixiao Long, Janos L. Tanyi, Kathleen T. Montone, Yi Fan, Xiaowen Hu, Youyou Zhang, Lin Zhang   +18 more
doaj  

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

Advanced Science, EarlyView.
Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu   +9 more
wiley   +1 more source

Genome-wide analysis of the diatom cell cycle unveils a novel type of cyclins involved in environmental signaling

Genome Biology, 2010
BackgroundDespite the enormous importance of diatoms in aquatic ecosystems and their broad industrial potential, little is known about their life cycle control.
Marie J. J. Huysman, Cindy Martens, K. Vandepoele, Jeroen T. F. Gillard, E. Rayko, M. Heijde, C. Bowler, D. Inzé, Y. Peer, L. De Veylder, W. Vyverman   +10 more
semanticscholar   +1 more source

Proliferating cell nuclear antigen (PCNA)/cyclin in activated human T lymphocytes. [PDF]

, 1987
Pekka Kurki, Martin Lotz, Kenji Ogata, Elina Tan   +3 more
openalex   +1 more source

Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR‐Altered Bladder Cancer

Advanced Science, EarlyView.
Coatomer protein complex subunit α facilitates the transport of the cargo protein LRPPRC across the Golgi complex and enhances its stability, thereby increasing LRPPRC expression; LRPPRC promotes the stability of ID3 mRNA in an m6A‐dependent manner, thereby decreasing the transcriptional activity of p16 and p21, which leads to increased erdafitinib ...
Huayuan Zhao, Xincheng Gao, Yangkai Jiang, Yanchao Yu, Liang Wang, Jiayin Sun, Miao Wang, Xing Xiong, Chao Huang, Hui Zhang, Guosong Jiang   +10 more
wiley   +1 more source

Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis.

PLoS Genetics, 2014
Loss of function of cyclin E1 or E2, important regulators of the mitotic cell cycle, yields viable mice, but E2-deficient males display reduced fertility.
Laetitia Martinerie, Marcia Manterola, Sanny S W Chung, Sunil K Panigrahi, Melissa Weisbach, Ana Vasileva, Yan Geng, Peter Sicinski, Debra J Wolgemuth   +8 more
doaj   +1 more source