BMEMat, EarlyView.Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu +13 more
wiley +1 more source
Decoding Cdk1 control: from mitotic thresholds to meiotic specificity. [PDF]
Chromosome ResTouati SA.
europepmc +1 more source
Dynamics of natural killer cell function upon recurrent stimulation
Biotechnology Progress, EarlyView.Weekly stimulation of peripheral blood‐derived NK cells with engineered K562 feeder cells resulted in two distinct growth phases, shifting around Day 21–26. Cells in growth phase 2 exhibited slower growth, reduced metabolic activity, and lower cytotoxicity than cells from growth phase 1, which has implications for NK cell biomanufacturing.
Jennifer One +4 more
wiley +1 more source
Arabidopsis AUGMIN8 Contains Two Independent Microtubule Association Domains
Cytoskeleton, EarlyView.ABSTRACT Plant cells create a plasma membrane‐associated network of microtubules that are nucleated by γ‐tubulin ring complexes primarily through microtubule‐dependent microtubule nucleation (MDMN). This dynamic array organizes into specific patterns in response to developmental and environmental cues to influence primary cell wall construction.
Naveen K. Chana +2 more
wiley +1 more source
High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants. [PDF]
Nat CommunÖrd M +10 more
europepmc +1 more source
A Computational Workflow for Cell Line Profiling by Imaging Mass Cytometry
Cytometry Part A, EarlyView.ABSTRACT In single‐cell spatial phenotyping biology, imaging mass cytometry (IMC) stands out as a cutting‐edge, highly multiplexed technology driving discoveries across various disease areas. In vitro profiling relies on tumor‐derived cancer cell lines, known for their diverse morphologies and phenotypes.
Alexandre Bouzekri +2 more
wiley +1 more source
The molecular aspects in prostatic cancer, unraveling the role of CDKs in prostate cancer progression. [PDF]
Discov OncolFarjami Z +4 more
europepmc +1 more source
The multiple hit model of infantile and epileptic spasms: The 2025 update
Epilepsia Open, EarlyView.Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou +6 more
wiley +1 more source
Dual-Input Regulation of β-Cell Proliferation by ATF6α and Glucose via E2F1. [PDF]
DiabetesLanda-Galvan HV +5 more
europepmc +1 more source
Highly purified cannabidiol (CBD) in CDKL5 deficiency disorder (CDD): Open‐label prospective study
Epilepsia Open, EarlyView.Abstract Objective CDKL5 deficiency disorder (CDD) is an early‐onset developmental and epileptic encephalopathy characterized by frequent drug‐resistant seizures, cerebral visual impairment, motor dysfunction, and sleep and gastrointestinal disturbances.
Marco Perulli +12 more
wiley +1 more source