Results 151 to 160 of about 130,501 (296)

Exploiting targeted degradation of cyclins and cyclin-dependent kinases for cancer therapeutics: a review. [PDF]

J Zhejiang Univ Sci B
Zheng S, Chen Y, Zhu Z, Li N, He C, Koeffler HP, Han X, Wei Q, Xu L.   +8 more
europepmc   +1 more source

Isolated absence epilepsy associated with a de novo FBXW7 missense variant in the F‐box domain

Epilepsia Open, EarlyView.
Abstract The FBXW7 gene encodes a substrate‐recognition component of the Skp1‐Cul1‐F‐box (SCF) E3 ubiquitin ligase complex, which targets key regulatory proteins for proteasomal degradation. Recently, loss‐of‐function FBXW7 variants have been associated with a novel neurodevelopmental disorder characterized by heterogeneous clinical features.
Anees Muhammad, Mohammad Sadegh Shams Nosrati, Alireza Dostmohammadi, Francesca Madia, Maria Margherita Mancardi, Stefania Fornarino, Luca Bosisio, Zahra Hoseini Tavassol, Mir Davood Omrani, Federico Zara, Marcello Scala   +10 more
wiley   +1 more source

Frontiers in Cell-Cycle-Targeting Therapies: Addressing the Heterogeneity of the Cancer Cell Cycle. [PDF]

Cancers (Basel)
Ganesan IP, Kiyokawa H.
europepmc   +1 more source

Cyclin [PDF]

, 2020
openaire   +1 more source

Loss of cyclin‐dependent kinase‐like 5 results in susceptibility to audiogenic seizures in mice

Epilepsia Open, EarlyView.
Abstract CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental encephalopathy characterized by early‐onset, treatment‐resistant epilepsy. Mice lacking CDKL5 display several clinically relevant phenotypes, but spontaneous seizures are not consistently reported, and it is unknown if CDD model mice are susceptible to sensory stimulus‐triggered ...
Jordan Higgins, Samuel Egan, Bilal El‐Mansoury, David C. Henshall, Omar Mamad   +4 more
wiley   +1 more source

Mechanism of D-type cyclin recognition by the AMBRA1 E3 ligase receptor. [PDF]

Sci Adv
Wang Y, Liu M, Wang S, Mai X, Wang X, Teng F, Lyu T, Su MY, Stjepanovic G.   +8 more
europepmc   +1 more source

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

Molecular Biology of the Cell, 1995
V. Sudakin, D. Ganoth, A. Dahan, H. Heller, J. Hershko, F. Luca, J. Ruderman, A. Hershko   +7 more
semanticscholar   +1 more source

Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

Exploration, EarlyView.
Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li, Qiuye Jia, Naixin Liu, Saige Yin, Junyuan Wang, Yujing Ding, Yuliu Yang, Ying Peng, Zeqiong Ru, Shaoyang Zhang, Bu'er Qi, Jun Sun, Li He, Ying Wang, Kun Guo, Xinwang Yang   +15 more
wiley   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation. [PDF]

Mol Oncol
Cardona-Benavides IJ, Cristobal-Vargas S, De Ramón C, Rojas EA, Misiewicz-Krzeminska I, Isidro I, Pérez JJ, Paiva B, Puig N, Alcoceba M, Mateos MV, Corchete LA, Cuadrado M, Gutiérrez NC.   +13 more
europepmc   +1 more source

Cuproptosis‐Related Genes in Immune Infiltration and Diagnosis in Hepatitis B Virus‐Related Acute Liver Failure

Exploration, EarlyView.
The role of cuproptosis in HBV‐ALF was explored via bioinformatics and liver biopsy tissues. There are some crosstalks among cuproptosis, immune infiltration, and ferroptosis (The figure was created by Bio Render). ABSTRACT Hepatitis B virus (HBV) infection poses a significant challenge to global health, particularly in developing countries such as ...
Jingwen Deng, Tao Zhu, Yueyang Wang, Sitong Zhang, Hong Deng, Guilan Quan, Tingting Peng, Chuanbin Wu, Huiqiang Cai, Chao Lu, Xiaopeng Cai   +10 more
wiley   +1 more source