Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors. [PDF]
Merk DJ+25 more
europepmc +1 more source
HN1 expression contributes to mitotic fidelity through Aurora A‐PLK1‐Eg5 axis
Abstract Hematological and neurological expressed 1 (HN1) is homolog of Jupiter protein from Drosophila melanogaster where it functions as a microtubule‐associated protein. However, in mammalian cells, HN1 is associated partially with y‐tubulin in centrosomes, Stathmin for stabilizing microtubules, and Cdh1 for regulating Cyclin B1 for cell cycle ...
Gülseren Özduman+3 more
wiley +1 more source
Prunin: An Emerging Anticancer Flavonoid. [PDF]
Rana JN, Mumtaz S.
europepmc +1 more source
A Requirement for Cyclin D3–Cyclin-dependent Kinase (cdk)-4 Assembly in the Cyclic Adenosine Monophosphate–dependent Proliferation of Thyrocytes [PDF]
Fabienne Depoortere+8 more
openalex +1 more source
Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley +1 more source
Positively charged specificity site in cyclin B1 is essential for mitotic fidelity. [PDF]
Heinzle C+9 more
europepmc +1 more source
Cyclin B1 expression in response to abrogation of the radiation‐induced G2/M block in HeLa cells [PDF]
Therina Theron, L. Böhm
openalex +1 more source
Lamellarin D Acts as an Inhibitor of Type I Collagen Production
COL1A2 gene, encoding type I collagen, is a key target for pulmonary fibrosis. We established a screening system to identify small molecules that inhibit COL1A2 gene expression. Using this system, we screen a library of compounds and identify lamellarin D as a potent inhibitor of COL1A2 expression, suggesting lamellarin D is a promising new lung ...
Daisuke Okuno+19 more
wiley +1 more source