Results 331 to 340 of about 141,408 (359)
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Cyclins and cell cycle checkpoints.
Annual Review of Pharmacology and Toxicology, 1999The eucaryotic cell cycle is regulated by the periodic synthesis and destruction of cyclins that associate with and activate cyclin-dependent kinases.
David G. Johnson, C. Walker
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Neuroscience Letters, 2003
Cyclins are regulatory proteins of the cell cycle which bind and activate kinases. In gliomas, contrary to many malignancies, cyclin D1 is rarely amplified, but together with other cyclins, it increases with anaplasia. In a series of 23 surgical biopsies of grade II and III oligodendroglioma, cyclin D1, E, A, B1, CDK4-6, CDK2, Cdc2 and p27/Kip.1 have ...
FIANO, VALENTINA +2 more
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Cyclins are regulatory proteins of the cell cycle which bind and activate kinases. In gliomas, contrary to many malignancies, cyclin D1 is rarely amplified, but together with other cyclins, it increases with anaplasia. In a series of 23 surgical biopsies of grade II and III oligodendroglioma, cyclin D1, E, A, B1, CDK4-6, CDK2, Cdc2 and p27/Kip.1 have ...
FIANO, VALENTINA +2 more
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Breast Cancer Research and Treatment, 1998
Cyclins are regulatory subunits for cyclin dependent kinases in the coordination of the cell cycle. Cyclins can also serve non-cell cycle functions, such as the transactivation of estrogen receptor by cyclin D. Evidence for the participation of the G1 cyclins D and E in breast cancer is summarized, including transgenic and knockout mice, transfections,
Qun Zhou, Patricia S. Steeg
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Cyclins are regulatory subunits for cyclin dependent kinases in the coordination of the cell cycle. Cyclins can also serve non-cell cycle functions, such as the transactivation of estrogen receptor by cyclin D. Evidence for the participation of the G1 cyclins D and E in breast cancer is summarized, including transgenic and knockout mice, transfections,
Qun Zhou, Patricia S. Steeg
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Cyclins and Cyclin-Dependent Kinases: Theme and Variations
1995Publisher Summary This chapter introduces cyclins and their partner—cyclin dependent kinases (CDKs)—and the ways in which CDK complexes can be regulated. Cyclins are intimately concerned with regulating and coordinating deoxyribonucleic acid (DNA) replication and cell division.
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Cyclin A and cyclin B1 overexpression in differentiated thyroid carcinoma
Medical Oncology, 2011Approximately 30% of patients with thyroid nodules have indeterminate or suspicious fine-needle aspiration (FNA) biopsy results. These patients usually undergo thyroidectomy because of cancer risk. Our aim was to determine diagnostic value of cyclin A and cyclin B1 immunohistochemistry added to routine cytology and their expression on histological ...
Asli Nar +3 more
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Journal of Cellular Physiology, 2011
The mechanism of homocysteine‐induced cell proliferation in human vascular smooth muscle cells (SMCs) remains unclear. We investigated the molecular mechanisms by which homocysteine affects the expression of cyclins A and D1 in human umbilical artery ...
J. Chiang +7 more
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The mechanism of homocysteine‐induced cell proliferation in human vascular smooth muscle cells (SMCs) remains unclear. We investigated the molecular mechanisms by which homocysteine affects the expression of cyclins A and D1 in human umbilical artery ...
J. Chiang +7 more
semanticscholar +1 more source
Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates
Nature, 2005Cell-cycle events are controlled by cyclin-dependent kinases (CDKs), whose periodic activation is driven by cyclins. Different cyclins promote distinct cell-cycle events, but the molecular basis for these differences remains unclear. Here we compare the specificity of two budding yeast cyclins, the S-phase cyclin Clb5 and the M-phase cyclin Clb2, in ...
Mart Loog, David O. Morgan
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Mitotic cyclins and cyclin-dependent kinases in melanocytic lesions
Human Pathology, 1998Recent evidence has implicated cyclins and cyclin-dependent kinases in the evolution and progression of various malignancies. We studied the immunohistochemical expression of cyclin A, cyclin B, and cyclin-dependent kinase p34cdc2 in a broad spectrum of benign and malignant melanocytic lesions.
Tien-Anh Tran +3 more
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G2 cyclins are required for the degradation of G1 cyclins in yeast
Nature, 1996Progression of the eukaryotic cell cycle is controlled by cyclin-dependent kinases (CDKs). Cdc28, the budding yeast homologue of Cdc2 (Cdk1), is required for both the G1/S and G2/M transitions of the cell cycle. The functional specificity of the Cdc28 kinase is determined by its association with G1 or G2 cyclins.
Marc Blondel, Carl Mann
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Seminars in Cancer Biology, 1999
Cyclins are known effectors of cellular proliferation. While originally considered as the product of cellular genes, it is now clear that representatives of this class of proteins can be encoded by certain viruses. One of these viruses is HHV-8, a gamma herpesvirus implicated as a causative agent of Kaposi's Sarcoma and lymphomas in humans.
Sibylle Mittnacht, Emma Cannell
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Cyclins are known effectors of cellular proliferation. While originally considered as the product of cellular genes, it is now clear that representatives of this class of proteins can be encoded by certain viruses. One of these viruses is HHV-8, a gamma herpesvirus implicated as a causative agent of Kaposi's Sarcoma and lymphomas in humans.
Sibylle Mittnacht, Emma Cannell
openaire +3 more sources