Results 71 to 80 of about 1,032 (168)

Photoprotective potential of gadusol against ultraviolet B radiation in melanocytes

Photochemistry and Photobiology, EarlyView.
Gadusol protects melanocytes from ultraviolet B (UVB)‐induced damage without cytotoxicity. Abstract The increasing incidence of skin cancer, including melanoma, combined with the need for ultraviolet (UV) filters that are safe for human health and marine ecosystems, is driving the search for new photoprotective agents.
Andressa Mai Matsumoto, Rocío Isla Naveira, Andy Joel Taipe Huisa, Marcelo Augusto Germani Marinho, Lais Zortéa, José María Monserrat, Agueda Elena Massa, María Sandra Churio, Ana Paula de Souza Votto   +8 more
wiley   +1 more source

A new approach to functionalized cyclobutanes: Stereoselective synthesis of the enantiomers of grandisol and fraganol

, 1995
Enantiomerically enriched (+)-grandisol and (+)-fraganol were synthesized using as the key step a new stereoselective synthesis of cyclobutanes fused to γ-lactones by a stereochemically-controlled intramolecular alkylation of α-benzenesulfonyl-γ-lactones.
Rodríguez, Carmen M., Martín, Víctor S., Martín, Tomás   +2 more
core   +1 more source

Enantioselective dearomative ortho-cycloaddition transformation of unactivated arenes by cage-confined visible-light photocatalysis

Nature Communications
Photoinduced dearomatization of arenes is a powerful strategy in organic synthesis to disrupt the stable aromaticity; however, the asymmetric dearomatization photocatalysis of unactivated arenes remains highly challenging and rare.
Jie Yang, Zhongshu Li, Xiantao Wu, Jie Chen, Sisi Huang, Yu-Lin Lu, Zhiwei Jiao, Cheng-Yong Su   +7 more
doaj   +1 more source

Depth of DNA photodamage in human corneas exposed to 222 nm or 254 nm UV

Photochemistry and Photobiology, EarlyView.
Representative confocal 3D image of a section of a human cornea showing nuclei in blue (Hoechst 33342) and green, which was assigned to cells exhibiting Alexa555 conjugated to anti‐CPD antibody. The depth of photodamage was measured in Z‐stacks of the human corneal epithelium after exposure of the anterior surface to 50 or 100 mJ/cm2 at 222 or 254 nm ...
Manuela Buonanno, Istvan R. Boldogh, Raabia Hashmi, Camryn Petersen, David Welch, Theresa C. Swayne, David J. Brenner   +6 more
wiley   +1 more source

Mechanochemistry of cyclobutanes

Science China Chemistry
AbstractThe field of polymer mechanochemistry has been revolutionized by implementing force-responsive functional groups—mechanophores. The rational design of mechanophores enables the controlled use of force to achieve constructive molecular reactivity and material responses.
Roberto Obregon, Junpeng Wang
openaire   +1 more source

Development of chalcones structure‐related to avobenzone: Photoprotection, photostability, and safety evaluation

Photochemistry and Photobiology, EarlyView.
Scaffold hopping strategy used to develop chalcones structure‐related to the avobenzone tautomer. Positive aspects of 2‐hydroxychalcones are highlighted. Abstract Chalcones are α,β‐unsaturated ketones with extended π‐conjugation, making them promising scaffolds for the development of organic UV filters.
Gabriela Zanella Marcon, Taíne de Bastos Brum, Nayara Fernanda Tokashike de Araujo, Gabriela Lascala Ramos, Bruna Cogo Borin, Ruth Barin, Aline Ferreira Ourique, André Passaglia Schuch, Andréa Inês Horn Adams, Lorena Rigo Gaspar Cordeiro, Letícia Cruz, Fernando Fumagalli   +11 more
wiley   +1 more source

New Strategies for Stereoselective Preparation of Densely Functionalized Cyclobutanes:

, 2022
Thesis advisor: Shih-Yuan LiuThis dissertation describes the utility of 1,2-azaborine motif as a 4C+1B+1N synthon in organic synthesis, especially for the preparation of densely functionalized cyclobutanes based on the framework of the 1,2-azaborine ...
Yang, Xinyu
core  

Revisiting the action spectrum of DNA damage: Chemiexcitation and the expanded biological spectrum of cyclobutane pyrimidine dimer formation

Photochemistry and Photobiology, EarlyView.
UVB and UVA generate cyclobutane pyrimidine dimers (CPDs) during irradiation (purple). After exposure ends, chemiexcitation in pigmented melanocytes continues to generate delayed CPDs (yellow), even as repair removes some pre‐existing lesions. Consequently, total CPD burden can rise while visible erythema fades.
Jyoti Srivastava, Marcus S. Cooke, Sanjay Premi   +2 more
wiley   +1 more source

Photoredox cobalt-catalyzed asymmetric desymmetric reductive coupling of cyclobutenes with alkynes

Nature Communications
Catalytic methods to couple alkynes and alkenes are highly valuable in synthetic chemistry. The cobalt-catalyzed intermolecular reductive coupling of alkenes and alkynes is particularly attractive due to the unique reactivity and cost-effectiveness of ...
Tianlong Zeng, Yuyang He, Ying Li, Lele Wang, Qiang Hu, Yongyi Li, Zhenwei Wei, Jianfei Chen, Xiaotian Qi, Jun Zhu   +9 more
doaj   +1 more source

UV signature mutation hyperhotspots as genomic dosimeters

Photochemistry and Photobiology, EarlyView.
Recurrent UV signature mutations are a sensitive and specific indicator of sun exposure. UV signature mutations (C → T mutations at dipyrimidine sites) were quantified using Duplex Sequencing and a stringent mutation calling protocol to identify true low‐abundance mutations.
Vijay Menon, Alejandro García‐Ruiz, Susan Neveu, Brenda Cartmel, Leah M. Ferrucci, Meg Palmatier, Christine Ko, Kenneth Y. Tsai, Mio Nakamura, Sa Rang Kim, Michael Girardi, Karl Kornacker, Douglas E. Brash   +12 more
wiley   +1 more source